Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ligand used together with protein type medicinal active component and oral protein type medicine preparation

A technology of active ingredients and pharmaceutical preparations, applied in the field of protein drugs, can solve the problems of patients with hypoglycemia, brain death, and difficult for patients to accept, and achieve the effect of eliminating resistance

Pending Publication Date: 2019-03-01
江苏平衡生物医药科技有限公司
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And the route of insulin administration makes it difficult for patients to accept
In addition, the disadvantages of this method of administration are: blood sugar control is unstable, patients are prone to hypoglycemia, and severe brain death may occur
Moreover, about two-thirds of diabetics in China do not have adequate blood sugar control

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ligand used together with protein type medicinal active component and oral protein type medicine preparation
  • Ligand used together with protein type medicinal active component and oral protein type medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] This example provides a ligand used in combination with protein-based pharmaceutical active ingredients, the ligand is composed of taurocholic acid and glycocholic acid at a mass ratio of 1:1.

Embodiment 2

[0036] This example provides a ligand used in combination with protein-based pharmaceutical active ingredients, the ligand is composed of taurocholic acid and glycocholic acid at a mass ratio of 1:2.

Embodiment 3

[0038] This example provides a ligand used in combination with protein-based pharmaceutical active ingredients, the ligand is composed of taurocholic acid and glycocholic acid at a mass ratio of 1:4.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to ligand used together with a protein type medicinal active component. The ligand is composed of taurocholic acid and glycocholic acid. The invention further provides an oral protein type medicine preparation. Specifically, the preparation is composed of a combined substance of the ligand and the protein type medicinal active component as a center which is wrapped with nano-liposomes. Due to the adoption of a nano-liposome wrapping layer, protection on a core structure can be improved, in addition, when the active component is insulin, phosphorus ions can be provided forself phosphorylation when insulin plasmid is in contact with a receptor. The oral protein type medicine preparation which is provided by the invention and has the insulin as the active component is capable of regulating blood sugar and blood fat, mainly has the effect of preventing complications of type-II diabetes, has bioavailability higher than that of injected insulin, causes no hypoglycemia,and in addition causes no brain death because of hypoglycemia; due to an orally taken mode, the preparation is convenient to administrate, the blood sugar is stable after administration, the inner environment of a body is stabilized, and good and wide application prospects can be achieved.

Description

technical field [0001] The invention relates to the field of protein drugs, in particular to a ligand used in combination with protein drug active ingredients and an oral protein drug preparation. Background technique [0002] At present, protein drugs are widely used in the diagnosis and treatment of diseases, but if they are administered orally, they are easily metabolized by enzymes in the digestive tract and lose their activity. Therefore, at present, most protein drugs are difficult to be made into oral preparations, and are mostly used in the form of injections. [0003] Among them, oral insulin has been developed for nearly half a century, but no one has been listed yet. There are two main reasons: 1. As a protein, insulin cannot pass through the powerful protease degradation system in the digestive tract; 2. Insulin cannot enter the blood through the small intestine wall. Therefore, it is considered that the development of an oral formulation of insulin is extremel...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/54A61K9/127A61K38/28A61K45/00A61P3/10
CPCA61K9/127A61K38/28A61K45/00
Inventor 薛南荣
Owner 江苏平衡生物医药科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products