A kind of alkali-soluble ganoderma polysaccharide ferulic acid ester and its preparation method and application
A technology of Ganoderma lucidum polysaccharide and ferulic acid ester, applied in the fields of polymer chemistry and medicinal chemistry, can solve the problems of insufficient concentration to prevent chemical damage and difficulty of ferulic acid entering the colon, and achieve the effect of improving water solubility and biological activity
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0035] Get 50g of ferulic acid and dissolve in 0.25M dimethyl sulfoxide solution, then weigh 50g of alkali-soluble ganoderma polysaccharide and add it to the solution, place it in a microwave electric field drug reactor, add 5g of 4-dimethylaminopyridine catalyst and 20mL of toluene with water agent, 40kV / cm electric field intensity of high-voltage electric field treatment for 20S, then use 250W microwave to raise the temperature to the set 80°C, react for 5min, stop heating, naturally cool to room temperature, and use three times the amount of absolute ethanol to precipitate , alcohol precipitation, until the ferulic acid reaction is negative. Suction filter to dryness, wash the product with methanol and ethanol respectively, and dry by rotary evaporation to obtain the alkali-soluble polysaccharide ferulate of Ganoderma lucidum.
Embodiment 2
[0037] Get 50g of ferulic acid and dissolve in 0.25M dimethyl sulfoxide solution, then weigh 40g of alkali-soluble ganoderma lucidum polysaccharide and add it to the solution, place it in a microwave electric field drug reactor, add 3g of 4-dimethylaminopyridine catalyst and 10ml toluene with water agent, 45kV / cm high-voltage electric field treatment for 5S, then use 180W microwave to heat up to the set 70°C, react for 10min, stop heating, naturally cool to room temperature, and precipitate with three times the amount of absolute ethanol , alcohol precipitation, until the ferulic acid reaction is negative. Suction filter to dryness, wash the product with methanol and ethanol respectively, and dry by rotary evaporation to obtain the alkali-soluble polysaccharide ferulate of Ganoderma lucidum.
Embodiment 3
[0039] Dissolve 50g of ferulic acid in 0.25M dimethyl sulfoxide solution, weigh 70g of alkali-soluble ganoderma lucidum polysaccharide into the solution, place it in a microwave electric field drug reactor, and add 2g of 4-dimethylaminopyridine catalyst And 30ml of toluene with water agent, 60kV / cm high-voltage electric field treatment for 10S, then use 150W microwave to heat up to the set 60°C, react for 15min, stop heating, naturally cool to room temperature, and use three times the amount of absolute ethanol Precipitation and alcohol precipitation until the ferulic acid reaction is negative. Suction filter to dryness, wash the product with methanol and ethanol respectively, and dry by rotary evaporation to obtain the alkali-soluble polysaccharide ferulate of Ganoderma lucidum.
PUM
| Property | Measurement | Unit |
|---|---|---|
| degree of substitution | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More