Drug eluting balloon

A balloon and drug technology, applied in medical science, balloon catheter, surgery, etc., can solve the problems of increasing cost and time

Active Publication Date: 2019-03-01
VASCUROS MEDICAL SHANGHAI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But it also increases the cost and t

Method used

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  • Drug eluting balloon
  • Drug eluting balloon
  • Drug eluting balloon

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0201] The test articles were coated with the same drug coating formulation and the same application method.

[0202] test article

[0203] Device A is a drug delivery device prepared similarly to Figure 3(a).

[0204] Device B is a drug delivery device prepared similarly to Figure 10(c).

[0205] Device C is a drug delivery device prepared similarly to Figure 10(a).

[0206] Device D is a typical balloon catheter.

[0207] method

[0208] In vitro test method adapted from Seidlitz et al. (2013 In Vitro Determination of Drug Transfer from Drug-Coated Balloons PLoS ONE8(12):e83992(doi:10.1371 / journal.pone.0083992).)

[0209] The following adaptations were made:

[0210] ·The wall of the model container is made of silicon tube.

[0211] • Imaging of the model vessel wall was not required, so the balloon was not treated with fluorescent substances.

[0212] ·Use ACN to extract the drug content and analyze it with a UV spectrophotometer at 227nm.

[0213] • The balloon is ...

specific Embodiment 2

[0217] The test articles were coated with the same drug coating formulation and the same application method.

[0218] test article

[0219] Device C is a drug delivery device prepared similarly to Figure 10(a).

[0220] Device D is a typical balloon catheter.

[0221] method

[0222] In vitro test method adapted from Seidlitz et al. (2013 In Vitro Determination of Drug Transfer from Drug-Coated Balloons PLoS ONE8(12):e83992(doi:10.1371 / journal.pone.0083992).)

[0223] The following adaptations were made:

[0224] ·The wall of the model container is made of silicon tube.

[0225] ·Shorten the transportation route.

[0226] • Imaging of the model vessel wall was not performed, so the balloon was not treated with fluorescent substances.

[0227] • Extract drug content in ACN and analyze using UV spectrometer at 227nm.

[0228] • The balloon is under a pressure of 12ATM.

[0229] result

[0230] Such as Figure 13 As shown, Device C with an elastic membrane, has signific...

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Abstract

The current invention relates to the provision of drug eluting balloons and balloon catheters, where the drug coating is protected by one or more sheaths and/or is applied to an elastic film, rather than to the balloon directly.

Description

technical field [0001] The present invention designs various drug-eluting balloons, which can be implanted in the body cavity of the human body to deposit the drug composition at the site to be treated. technical background [0002] The listing or discussion of a prior published document or any background material in this specification should not be taken as an acknowledgment that the document or background material is part of the state of the art or is common general knowledge. [0003] Coronary artery disease / peripheral artery disease is a common blood circulation disorder in which plaque builds up in the arteries that restrict blood flow to various parts of the body. The current typical treatment methods are: coronary artery bypass grafting, stent implantation and balloon angioplasty. Months after stenting and balloon angioplasty, some patients develop a narrowing of the vessel wall at the intervention site, called restenosis. The recognition of the problems associated ...

Claims

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Application Information

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IPC IPC(8): A61M25/10A61L29/08A61L29/16A61L31/16
CPCA61M25/10A61L29/08A61L29/16A61M2025/105A61L2300/606A61L2420/02A61L2420/06A61L31/16A61M2025/1081A61L2300/416
Inventor 骆静南王红蕾
Owner VASCUROS MEDICAL SHANGHAI CO LTD
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