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Methods and systems of multi-assay processing and analysis

A technology of preprocessing and processing unit, applied in the fields of multi-test processing and analysis and system, which can solve problems such as the complexity of scheduler and the influence of effective use of system resources

Active Publication Date: 2019-03-15
ABBOTT MOLECULAR INC A CORP ORGANISED & EXISTING UNDER THE LAWS OF THE STATE OF DELAWARE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with instruments processing multiple trial types simultaneously per round, unique trial scenarios have a significant impact on scheduler complexity and efficient use of system resources

Method used

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  • Methods and systems of multi-assay processing and analysis
  • Methods and systems of multi-assay processing and analysis
  • Methods and systems of multi-assay processing and analysis

Examples

Experimental program
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Embodiment 1

[0126] Example 1: Generation of a generic lockstep sample processing scheme

[0127] This example describes the generation of a single lockstep trial timing scheme that coordinates the processing for each type of trial to a common trial timing scheme in which all trials yield the same time and throughput regardless of where they are run on the automated device. A test or a combination of tests.

[0128]For various assays, including HIV, HCV, CT / NG, and HBV, identify pipetting steps, SPU cartridge setup steps, sample addition steps, pretreatment steps, digestion transfer steps, SPU processing steps, eluate transfer steps, and amplification / detection step. Each longest step (i.e., longest pipetting step, longest SPU cartridge setup step, longest sample addition step, longest pretreatment step, longest digestion transfer step, longest SPU processing steps, longest eluate transfer steps, and longest amplification / detection steps) were compiled into a single general idealized "l...

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Abstract

The instant disclosure provides methods of multi-assay processing and multi-assay analysis. Such multi-assay processing and analysis pertain to automated detection of target nucleic acids, e.g., as performed in the clinical setting for diagnostic purposes. Also provided are common assay timing protocols derived from a variety of individual nucleic acid amplification and analysis protocols and modified to prevent resource contention. The instant disclosure also provides systems and devices for practicing the methods as described herein.

Description

[0001] Cross References to Related Applications [0002] Pursuant to 35 U.S. C. § 119(e), this application claims priority from the filing date of U.S. Provisional Patent Application Serial No. 62 / 308,625, filed March 15, 2016, the contents of which are incorporated herein by reference. Background technique [0003] Molecular diagnostic tests, including methods based on nucleic acid amplification, have become the mainstay of clinical medicine and the variety of tests available and the demand for such tests by clinicians has increased dramatically. This demand puts pressure on clinical laboratories to not only process large volumes of samples, but also to perform various tests on the samples. Thus, there is a burden on clinical testing facilities to efficiently perform a wider range of different nucleic acid amplification-based tests. [0004] The test protocol defines all the reagents, processing steps, processing time, temperature profile, etc. required to process the sampl...

Claims

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Application Information

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IPC IPC(8): C12Q1/6806G01N33/48G01N33/50
CPCG01N33/48C12Q1/6806Y02A50/30C12Q2527/113C12Q2531/113C12Q2545/114C12Q2561/113B01L9/523C12Q1/6888G01N30/88G01N33/56983G01N35/00G01N35/00584G01N2035/00326
Inventor F·保罗斯克J·P·斯金纳J·凯斯勒S·S·娜娜
Owner ABBOTT MOLECULAR INC A CORP ORGANISED & EXISTING UNDER THE LAWS OF THE STATE OF DELAWARE