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Normal-temperature mechanical perfusion system capable of extending liver source

A technology of machinery and perfusion solution, applied in the field of mechanical perfusion system at room temperature, can solve the problems of limiting the scope of material collection, increasing the risk of rejection reaction and infection risk, and achieving the prevention of ischemia-reperfusion injury, good market prospects and social welfare value, effect of prolonging tolerance

Active Publication Date: 2019-03-26
嘉兴莱普晟医疗科技有限公司
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AI Technical Summary

Benefits of technology

This new type of blood circulating system uses specific solutions called hepatic peritoneal lavage (HP) instead of existing methods like hypothermic storage at room temperatures. These systems have been shown effective against oxidative stress caused by excessive oxygen levels inside tissues when stored under anesthestic conditions without causing damage from cold exposure. They also help preserve the quality of living organs such as kidneys while they are being preserved over time due to their ability to absorb harmful substances through its own membranes. Overall these technical improvements make them better suited for use worldwide than previous options.

Problems solved by technology

Technicians discusses different technical solutions aimed towards improving the performance of thermal circulatory insufficient bilips used for temporary liver replacement therapy. These technologies include advanced treatment options like partial compensator recovery systems, enzyme supplement treatments, non-thermal conditioners, and special preparations containing specific components. Additionally, there exist several alternative approaches involving infarct mass transfer procedures, fluid exchange processes, and hypotheses about how these alternatives help revitalize damaged organs before they die. Overall, this patented technology provides better patient outcomes when replacing lost parts of their own liver without sacrificing healthy ones.

Method used

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  • Normal-temperature mechanical perfusion system capable of extending liver source
  • Normal-temperature mechanical perfusion system capable of extending liver source
  • Normal-temperature mechanical perfusion system capable of extending liver source

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Composition and connection of a normal temperature mechanical perfusion system suitable for liver preservation

[0039] like figure 1 As shown, in the perfusion system (14), the central processing unit (1) is connected to the peristaltic pump (2), and the output power of the peristaltic pump 2 is controlled by the control unit (20) in the central processing unit (1), so Described peristaltic pump (2) controls the perfusion pressure and flow rate of perfusion fluid through the change of output power, and further, peristaltic pump (2) is connected with liver perfusate storage (3), and described liver perfusion storage (3) is two layers inside and outside , between the inner and outer layers, a cold and heat regulating tube is arranged, and the cold and heat regulating tube is controlled by the control assembly (20) for regulating the temperature of the perfusate; a temperature sensor (16) is provided in the liver perfusate storage (3), For monitoring the temper...

Embodiment 2

[0043] Example 2 Acquisition and perfusion of donor liver

[0044] 1 Laboratory animal

[0045] There are 20-25 male Chinese miniature pigs, weighing 30±3Kg. All experimental animals were treated humanely and complied with the "Guidelines for the Management and Use of Laboratory Animals" issued by the National Institutes of Health, and the experimental protocol was approved by the relevant laboratory animal ethics committee.

[0046] 2. Method

[0047] (1) Experimental animals were fasted for 8 hours before surgery. Anesthesia was induced by intramuscular injection of sodium pentobarbital, and the body weight was recorded. The limbs were fixed on the operating table in the supine position, high-flow oxygen was inhaled, skin preparation was performed, the anterior chest leads were connected for ECG monitoring, and the end of the pigtail was connected with a blood oxygen saturation probe. The scalp needle was used to establish peripheral venous access through the marginal ea...

Embodiment 3

[0052] Example 3 The effect of naringenin-7-O-acetate on mechanical perfusion in vitro preserved liver

[0053] Naringenin (naringenin) has antibacterial, anti-inflammatory, free radical scavenging, antioxidant, antitussive and expectorant, blood lipid lowering, anticancer and antitumor, antispasmodic and choleretic, prevention and treatment of liver disease, inhibition of platelet aggregation, anti-atherosclerosis However, whether it can be used to preserve the isolated liver, especially whether its derivative naringenin-7-O-acetate can be used as a perfusate component, which is beneficial to the mechanical perfusion preservation of the liver, is currently unknown. . In order to explore the effect of naringenin-7-O-acetate on the preserved liver in vitro by mechanical perfusion, two different liver perfusion solutions were designed in this example, and the specific components are shown in Table 1:

[0054] Table 1 Composition of Perfusate A and Perfusate B (1000mL)

[0055]...

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Abstract

The invention provides a normal-temperature mechanical perfusion system capable of extending liver source. The mechanical perfusion system comprises a central processing unit assembly, a power assembly, a liver storage assembly, a liquid circulating assembly, a monitoring assembly and a liquid collection assembly, wherein the liquid circulating assembly comprises a liver perfusion fluid storage, liver perfusion fluid is stored in the liver perfusion fluid storage, and the liver perfusion fluid contains a naringenin derivative and does not contain red blood cell.

Description

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Claims

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Application Information

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Owner 嘉兴莱普晟医疗科技有限公司
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