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A balloon with controllable flow in the body to reduce ischemia-reperfusion injury

A controllable ischemia-reperfusion technology, applied in balloon catheters, catheters, etc., can solve problems such as organ damage, pH imbalance, and vascular injury in the infarcted area

Active Publication Date: 2021-09-14
HUNAN PROVINCIAL PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, acute vascular occlusive disease is the main cause of death in the Chinese population, including acute myocardial infarction, cerebral infarction, peripheral arterial vascular embolism, etc., patients with acute vascular occlusive disease, the preferred method is emergency interventional treatment to open the infarct-related blood vessels, and then Perfuse the infarcted area; however, during emergency interventional treatment, directly opening the occluded blood vessel will cause further damage, which is called ischemia-reperfusion injury, resulting in further damage to the organs in the infarcted area
[0003] Although the existing balloon perfusion equipment understands ischemic injury, the specific cause of the injury is not clear
At present, there is a postconditioning mode (ischemic postconditioning) to avoid ischemia-reperfusion injury. The specific operation method is to use the balloon to repeatedly expand and retract in the blood vessel, causing the blood flow in the blood vessel to pulse in an "all or nothing" manner. Intermittent recovery is the process of adapting the ischemic area to reperfusion. Animal experiments have proved that this post-conditioning mode can partially alleviate ischemia-reperfusion injury; however, this "all or nothing" pulsed blood flow recovery itself is It may lead to ischemia-reperfusion injury. At the same time, repeated expansion and retraction of the balloon may lead to thrombus and plaque shedding, causing and aggravating no-reflow; mostly negative
[0004] The traditional method of interventional therapy for acute vascular occlusive diseases is to use intravascular guide wires and balloons to quickly open the acutely occluded blood vessels. However, the applicant has found through a large number of animal experiments and clinical experiments that the blood flow of the occluded blood vessels is restored, and sudden reperfusion will occur. In the distal myocardium, the sudden recovery of energy and oxygen leads to a sudden change in the intracellular environment, a sudden imbalance in pH, etc., which causes severe contraction and damage to the membrane of edema cells, resulting in further necrosis of ischemic organs

Method used

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  • A balloon with controllable flow in the body to reduce ischemia-reperfusion injury
  • A balloon with controllable flow in the body to reduce ischemia-reperfusion injury
  • A balloon with controllable flow in the body to reduce ischemia-reperfusion injury

Examples

Experimental program
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Embodiment 1

[0028] see figure 1 , 2In this embodiment, the balloon with controllable flow rate in the body for reducing ischemia-reperfusion injury includes: a tail joint 1, a hard push tube 2 (a metal push tube is used in this embodiment), a perfusion hose (including a proximal soft tube) Tube 3 and distal hose 6), balloon 5, guide wire 7 and flow control components; the perfusion hose is a double-layer tube structure. There is a first pressurized chamber 9 inside the metal push tube 2, and a second pressurized chamber 10 inside the inner tube of the perfusion hose. The two communicate with each other to form a complete pressurized chamber. The first pressure chamber 9 is a hollow cavity along the central axis of the metal push tube 2, and the second pressure chamber 10 is a hollow cavity arranged in the perfusion hoses 3, 6, and one end thereof is connected to the first pressure chamber. Cavity 9 communicates, and the other end is provided with a pressure hole at the position where th...

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PUM

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Abstract

The invention provides a balloon for reducing ischemia-reperfusion injury with controllable flow in the body, and relates to the field of interventional medical devices. The balloon for reducing ischemia-reperfusion injury with controllable flow in the body of the present invention includes: Mass pushing tube, perfusion hose, balloon, guide wire and flow control parts, the flow control part is composed of inner perfusion hole, wrapping outer sheath and inner perfusion hole mark; the controllable flow in the body of the present invention reduces ischemia-reperfusion injury After the balloon is inflated, the balloon does not release the balloon, and can accurately and slowly perfuse the distal end of the infarction area or ischemic area by sliding and wrapping the outer sheath, thereby avoiding ischemia-reperfusion injury; while perfusing the distal end, the balloon Only one expansion and release is required, which can reduce or avoid the occurrence of vascular injury, plaque detachment and no-reflow in distal vessels.

Description

Technical field: [0001] The invention relates to the field of interventional medical devices, in particular to a balloon for reducing ischemia-reperfusion injury with controllable flow in the body used in acute vascular occlusion. Background technique: [0002] At present, acute vascular occlusive disease is the main cause of death in the Chinese population, including acute myocardial infarction, cerebral infarction, peripheral arterial vascular embolism, etc., patients with acute vascular occlusive disease, the preferred method is emergency interventional treatment to open the infarct-related blood vessels, and then Perfuse the infarcted area; however, in the process of emergency intervention, directly opening the occluded blood vessel will cause further damage, which is called ischemia-reperfusion injury, resulting in further damage to the organs in the infarcted area. [0003] Although the existing balloon perfusion equipment understands the ischemic injury, the specific ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M25/10
CPCA61M25/1025A61M25/104A61M2025/1079A61M25/10181A61M25/10184
Inventor 陶美伊吴威周雅妮李凤张宇邹琼超周金花李利花李珊珊廖丹梁承洋谭波宇谢娇王长录曹彦刘征宇潘宏伟郑昭芬余登峰
Owner HUNAN PROVINCIAL PEOPLES HOSPITAL
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