Microfluidic biological detection system and method

A biological detection system and biological detection technology are applied in the field of microfluidic biological detection to achieve the effect of reducing the difficulty of preparation and reducing the cost

Inactive Publication Date: 2019-03-26
DONGGUAN UNIV OF TECH
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Problems solved by technology

[0005] The purpose of the present invention is to provide a microfluidic biological detection system and method to overcome the def

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  • Microfluidic biological detection system and method

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Embodiment Construction

[0036] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0037] In order to make the above objects, features and advantages of the present invention more comprehensible, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0038] figure 1 It is a schematic structural diagram of the microfluidic biological detection system of the present invention. Such as figure 1 As shown, the microfluidic biological detection system specifically...

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Abstract

The invention discloses a microfluidic biological detection system and method. The system comprises a microfluidic biological chip, an evanescent wave optical fiber SERS (Surface Enhanced Raman Scattering) probe and a portable Raman spectrometer, wherein the microfluidic biological chip comprises a microfluidic channel and a probe connector; the microfluidic channel is located in the microfluidicbiological chip; the probe connector penetrates to a detection region of the microfluidic channel in the microfluidic biological chip from the outer part of the microfluidic biological chip; a probe comprises a transmission section and a sensitive section; the sensitive section is composed of an evanescent wave optical fiber structure and a noble metal nano-structure with a localized field enhancement property; the evanescent wave optical fiber structure is located at one end of the transmission section; the noble metal nano-structure is located on the surface of the evanescent wave optical fiber structure; when microfluidic biological detection is carried out, the sensitive section of the probe stretches into the detection region of the microfluidic channel through the probe connector; and a second end of the transmission section is connected with the portable Raman spectrometer. By adopting the microfluidic biological detection system and method, the preparation difficulty and cost of a substrate can be effectively reduced and the microfluidic biological detection sensitivity is improved.

Description

technical field [0001] The invention relates to the field of microfluidic biological detection, in particular to a microfluidic biological detection system and method. Background technique [0002] Microfluidic biological detection refers to the detection of biological samples using microfluidic biochips. It has the advantages of high integration, less reagent consumption, fast analysis speed, and high throughput. It has important applications in biomedical and life science research. . As an important spectroscopic technique, surface enhanced Raman scattering (SERS) spectroscopy has been widely used in microfluidic biological detection. [0003] In order to realize microfluidic biological SERS spectrum detection, both the SERS substrate and the Raman spectrum detection instrument are essential. At present, there are two common construction methods for microfluidic SERS substrates: one is to achieve SERS enhancement by uniformly mixing the noble metal nanoparticle sol and t...

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Application Information

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IPC IPC(8): G01N21/65B01L3/00
CPCB01L3/5027B01L2200/10B01L2300/0861G01N21/65G01N21/658G01N2021/655
Inventor 刘晔周飞王红成凌东雄
Owner DONGGUAN UNIV OF TECH
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