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Zinc ion wrapped nanometer particles, and preparation method and application of zinc ion wrapped nanometer particles

A nanoparticle, zinc ion technology, applied in pharmaceutical formulations, coatings, pharmaceutical sciences, etc., can solve problems such as toxic medical products, excessive zinc ion release, and poor zinc ion loading effect.

Inactive Publication Date: 2019-03-29
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the existing methods for loading zinc ions onto the surface of medical materials have problems such as poor zinc ion loading effect, too fast release of zinc ions (leading to toxicity), or medical products do not have blood coagulation function.

Method used

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  • Zinc ion wrapped nanometer particles, and preparation method and application of zinc ion wrapped nanometer particles
  • Zinc ion wrapped nanometer particles, and preparation method and application of zinc ion wrapped nanometer particles
  • Zinc ion wrapped nanometer particles, and preparation method and application of zinc ion wrapped nanometer particles

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preparation example Construction

[0026] A kind of preparation method of the nanoparticle that internal coating zinc ion provides in the embodiment of the present invention, comprises: after zinc salt solution and polylysine (PLL) solution are mixed and reacted to obtain zinc ion chelating solution; Zinc ion chelating mixed with heparin saline solution.

[0027] It should be noted that please combine figure 1 , mix the zinc salt and the polylysine solution to make the amino group on the polylysine coordinate with the zinc ion to form a chelate, and then through the positive charge of the polylysine in the chelate and the The strongly negatively charged heparin undergoes electrostatic binding to form nanoparticles. A higher dose of zinc can be introduced through the chelation of zinc ions and polylysine, and the introduction of zinc after loading on medical materials can delay high doses of zinc from exerting its biological effects.

[0028] Heparin contains a large number of sulfate groups in its structure, ...

Embodiment 1

[0039] This embodiment provides a method for preparing nanoparticles with zinc ions wrapped inside, which includes the following steps: adding 0.0005 mmol / L zinc chloride solution dropwise to polylysine with a concentration of 0.3 mg / mL and a weight average molecular weight of 150 KDa. acid solution, stirred for 2 hours; then under the condition of magnetic stirring, 5 mg / mL sodium heparin solution was added dropwise to the reacted mixed solution for 2 hours at room temperature, wherein zinc chloride solution, polylysine solution The volume ratio to heparin sodium solution is about 1:0.9:1.8.

Embodiment 2

[0041] This embodiment provides a method for preparing nanoparticles with zinc ions wrapped inside, which comprises the following steps: adding dropwise a 10 mmol / L zinc nitrate solution to polylysine with a concentration of 1.0 mg / mL and a weight average molecular weight of 300 KDa solution, stirred for 3 h; then under the condition of magnetic stirring, 10 mg / mL heparin potassium solution was added dropwise to the reacted mixed solution for 3 h at room temperature, wherein zinc nitrate solution, polylysine solution and heparin potassium The volume ratio of the solution is about 1:1.1:2.2.

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Abstract

The invention discloses zinc ion wrapped nanometer particles, and a preparation method and application of the zinc ion wrapped nanometer particles, and relates to the technical field of preparation ofnanometer materials. The preparation method of the zinc ion wrapped nanometer particles comprises the following steps of performing a mixing reaction on a zinc salt solution with a polylysine solution to obtain zinc ion chelating liquor; and performing a mixing reaction on the zinc ion chelating liquorand a heparinate solution. The zinc ion wrapped nanometer particles are chelated substances formed by wrapping polylysine and zinc ions with polylysine, so that the content of the zinc ions in the prepared nanometer particles is adjustable. High-dosage zinc elements can be introduced, and in themanner of introducing the zinc elements, exerting the biological action of high-dosage zinc can be delayed. The materials namely the nanometer particles which have a blood coagulation function, are high in zinc ion content and slow in release effect of the zinc ions can be applied to preparation of zinc-containing medical materials.

Description

technical field [0001] The invention relates to the technical field of preparation of nanometer materials, and in particular to nanoparticle with zinc ions wrapped inside, its preparation method and application. Background technique [0002] After developing and designing several generations of cardiovascular materials, there are still problems in late and very late arterial restenosis after material implantation. It is often necessary to promote the growth of surface cells on the surface of the product in the early stage, and to design anti-stenosis in the late and very late arteries to ensure the adaptability of the implanted material in the service environment. At the same time, it has an inert or even inhibiting effect on smooth muscle cells to reduce The emergence of late and very late arterial restenosis problems. [0003] However, the existing methods for loading zinc ions onto the surface of medical materials have problems such as poor loading effect of zinc ions, e...

Claims

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Application Information

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IPC IPC(8): A61L31/08A61L31/10A61L31/16A61L31/14
CPCA61L31/088A61L31/10A61L31/14A61L31/16A61L2300/102A61L2300/236A61L2300/416A61L2300/42A61L2300/602A61L2300/624A61L2400/18C08L5/10C08L77/04
Inventor 陈俊英曾峥谢银红李霞李莉谭建英王焕然魏来翁亚军黄楠
Owner SOUTHWEST JIAOTONG UNIV
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