Application of TMSB10 in diagnosis and treatment of glioma

A technology of glioma and glioma cells, which is applied in the fields of biomedicine and molecular biology, can solve the controversial problems of the functional correlation of tumor metastasis, and achieve the effect of reducing tumorigenicity in vivo

Inactive Publication Date: 2019-04-09
SHANDONG UNIV QILU HOSPITAL
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However, the inventors found that the functional ...

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  • Application of TMSB10 in diagnosis and treatment of glioma
  • Application of TMSB10 in diagnosis and treatment of glioma
  • Application of TMSB10 in diagnosis and treatment of glioma

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Embodiment

[0083] 1. Materials and methods

[0084] 1.1 Cox proportional hazard model and TCGA database analysis

[0085] Use the Cox proportional hazard model to select genes related to patient survival and build a predictive model for future predictions. Outcome time is defined as the overall survival rate in months, and the disease-free survival rate in months. Select N genes to construct a Cox regression model; for each gene Gj (j=1, 2,..., N), the following Cox model is established for the life state or the risk of death at time t.

[0086]

[0087] among them Is the baseline hazard function of gene Gj, and X1, X2,..., XP are covariates. The adjusted covariates include race, age, gender, KPM (Karnofsky performance) score, tumor status, and neoadjuvant tumor history. From the Cancer Genome Atlas (TCGA, http: / / cancergenome.nih.gov), the transcription abundance of TMSB10 related to glial was discovered. In summary, 702 glioma cases from the TCGA database were analyzed, including low-grad...

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Abstract

The invention provides an application of TMSB10 in diagnosis and treatment of glioma. Specifically, research finds that expression of TMSB10 increases with malignancy degree of glioma and is negativecorrelation with the survival rate. The TMSB10 silences and inhibits proliferation, attack and migration (MMP-9 and N-Cadherin) in U87MG and U251 cell lines, induces cell apoptosis, inhibits in-vitrocell cycles (p21, CDK4 and cyclin D1) through PI3K-AKT/ERK signal pathways (PI3K, P-AKT and p-ERK) and reduces in-vivo tumorigenicity. It indicates that the TMSB10 is an oncogene participating in occurrence and development of glioma and can be used as a biomarker and treatment target of the glioma.

Description

Technical field [0001] The invention belongs to the technical field of biomedicine and molecular biology, and specifically relates to the application of TMSB10 in the diagnosis and treatment of glioma. Background technique [0002] Disclosure of the background information is only intended to increase the understanding of the overall background of the present invention, and is not necessarily regarded as an acknowledgement or in any form suggesting that the information constitutes the prior art known to those of ordinary skill in the art. [0003] Glioma is the most common primary central nervous system (CNS) malignant tumor. Approximately 210,000 people worldwide are diagnosed as glioma every year, and the 5-year survival rate is less than 10%. According to its source and World Health Organization definition, there are three types of gliomas, including astrocytoma (astrocytoma grade I and II), grade III (anaplastic astrocytoma) and grade IV (GBM) . Due to the uncontrolled prolife...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886G01N33/574A61K45/00A61P35/00
CPCA61K45/00A61P35/00C12Q1/6886C12Q2600/158G01N33/57407G01N33/57496G01N2333/5759
Inventor 李刚薛皓熊叶孙晓朋高校赵荣荣
Owner SHANDONG UNIV QILU HOSPITAL
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