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C-type arsenic molybdate and synthesis method and application thereof

A technology of arsenic molybdate and synthesis method, which is applied in drug combination, antineoplastic drugs, organic chemistry, etc., can solve the problems of unsatisfactory antitumor effect and damage to normal body cells, and achieve good stability and improve stability and yield, strong antitumor effect

Active Publication Date: 2019-04-16
KUNMING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the current research focuses on polyacid compounds with classical structures. At the same time, when polyacids are used as antiviral and antitumor drugs, there are often problems such as unsatisfactory antitumor effects and damage to normal somatic cells. Therefore, new polyacids are sought Anti-tumor compound models have become a research focus in the field

Method used

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  • C-type arsenic molybdate and synthesis method and application thereof
  • C-type arsenic molybdate and synthesis method and application thereof
  • C-type arsenic molybdate and synthesis method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Take (NH 4 ) 6 Mo 7 o 24 4H 2 O (0.5 g, 0.4 mmol) and As 2 o 3 (0.04g, 0.2mmol) was dissolved in 20 mL of distilled water and stirred for 10 minutes, then 10ml of hydrochloric acid containing 10mmol and 0.6 mmol FeCl was added dropwise 3 ·6H 2O (0.17g) in water. The mixed solution was stirred for 10 min, and the brown solution of the obtained solution continued to react for 45 min under 200W microwave radiation conditions. After cooling to room temperature, filter, and seal the filtrate with a film with small holes for slow evaporation. Blocky crystals were obtained after two weeks. Rinse with methanol and air dry. Yield 29%, theoretical value of element analysis: C, 1.48; H, 1.67; Mo, 41.41; Fe, 3.44; theoretical value: C, 1.43; H, 1.97; N, 4.31, Mo, 46.47; Fe, 7.99; As3.30. Anal. Calcd for 1: H, 1.97; N,4.31, Mo, 46.47; Fe, 7.99; As 3.30, found: H, 1.97; N,4.20, Mo, 46.26; Fe, 8.21; As 3.13 , %.

[0022] The C-type arsenomolybdate compound prepared in thi...

Embodiment 2

[0032] A C-type arsenic molybdate, characterized in that the molecular formula of the C-type arsenic molybdate is: (NH 4 ) 14 Fe 0.5 [As 2 Fe 6 Mo 22 o 85 (H 2 O)] 16H 2 O, crystallized in triclinic crystal system, P-1 space group, unit cell parameters are a=12.6245(4)Å, b=16.8421(5)Å, c=27.1396(8)Å; α=98.892(2)° , β=16.8421(5)°, γ=104.129(3)°. The same amount of enantiomers exists in the unit cell of the C-type arsenomolybdate.

[0033] A kind of synthetic method of C type arsenic molybdate, specifically as follows: get the (NH 4 ) 6 Mo 7 o 24 4H 2 O and As 2 o 3 Dissolve in distilled water and stir for 8 minutes, then add FeCl-containing 3 ·6H 2 1mmol / ml hydrochloric acid aqueous solution of O, the added FeCl 3 ·6H 2 O and As 2 o 3 The molar ratio of the solution is 3:1; the mixed solution is stirred for 8 minutes, and the resulting brown solution is placed under 100W microwave radiation conditions to continue the reaction for 43 minutes, cooled to room ...

Embodiment 3

[0035] A C-type arsenic molybdate, characterized in that the molecular formula of the C-type arsenic molybdate is: (NH 4 ) 14 Fe 0.5 [As 2 Fe 6 Mo 22 o 85 (H 2 O)] 16H 2 O, crystallized in triclinic crystal system, P-1 space group, unit cell parameters are a=12.6245(4)Å, b=16.8421(5)Å, c=27.1396(8)Å; α=98.892(2)° , β=16.8421(5)°, γ=104.129(3)°. The same amount of enantiomers exists in the unit cell of the C-type arsenomolybdate.

[0036] A kind of synthetic method of C type arsenic molybdate, specifically as follows: get the (NH 4 ) 6 Mo 7 o 24 4H 2 O and As 2 o 3 Dissolve in distilled water and stir for 12 minutes, then add FeCl-containing 3 ·6H 2 1mmol / ml hydrochloric acid aqueous solution of O, the added FeCl 3 ·6H 2 O and As 2 o 3 The molar ratio is 3:1; the mixed solution was stirred for 12 minutes, and the obtained brown solution was placed under 300W microwave radiation conditions to continue the reaction for 47 minutes, cooled to room temperature, ...

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Abstract

The invention discloses a C-type arsenic molybdate and a synthesis method and application thereof. The molecular formula of the C-type arsenic molybdate is (NH4)14Fe0.5 [As2Fe6Mo22O85(H2O) ] 16H2O, and the C-type arsenic molybdate is crystallized in a triclinic system and a P-1 space group, wherein the cell parameter is a=12.6245(4),b=16.8421(5),c=27.1396(8); alpha =98.892(2) degree, beta=16.8421(5) degree, gamma=104.129(3) degree. According to the novel C-type arsenic molybdate synthesized by the method, a polyacid compound with the structure is synthesized by a microwave-assisted method forthe first time, so that the stability and the yield of crystals are further improved. At the same time, the single crystal structure also provides a new data for the crystal database, and the biological activity shows that the compound has stronger anti-tumor effect than PM-8.

Description

technical field [0001] The invention belongs to the technical field of novel compound preparation, and in particular relates to a C-type arsenic molybdate and its synthesis method and application. Background technique [0002] The research on the antitumor activity of new polyacid compounds has gradually become a research hotspot in the field of polyacid chemistry in recent years. Japan's Yamase et al conducted an in-depth study on the antitumor effect of isopolymolybdate, and found that heptamolybdate heptamolybdate trihydrate hexaisopropylammonium (NH 3 Pri) 6 [Mo 7 o 24 ]·3H 2 O (PM-8) has anti-tumor activity, and the redox mechanism of PM-8 anti-tumor effect was proposed for the first time. In 2013, Zhou Baibin's research group found that imidazole-modified triple-deficient Keggin-type bismuth tungstic acid can inhibit the proliferation and induce apoptosis of SGC-7901 cells; in 2014, Wang Enbo's research group found that 1,2-ethylenediamine modified vanadium The s...

Claims

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Application Information

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IPC IPC(8): C07F19/00A61P35/00
CPCA61P35/00C07F19/00
Inventor 吴琼句红萍陶剑王宝玲
Owner KUNMING UNIV
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