Application of polyphyllin in products for resisting malassezia fufur and candida albicans

A technology of Candida albicans and papaya saponins, which can be used in applications, antifungal agents, chemicals for biological control, etc., and can solve problems such as narrow antibacterial spectrum

Inactive Publication Date: 2019-04-19
FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

The mechanism of action of fluconazole is similar to that

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Inhibitory effect of saponins of Pteridophyta on Malassezia furfur and Candida albicans

[0026] 1Materials and methods

[0027] 1.1 Materials: There are four monomer components of saponins I, II, VI, and VII and the total saponins of saponins. The relevant information is as follows:

[0028] Ⅰ, CAS number: 50773-41-6; molecular formula: C44H70O16; molecular weight: 855.02; Ⅱ, CAS number: 76296-72-5; molecular formula: C44H70O16; molecular weight: 855.017; Ⅵ, CAS number: 55916-51-3; molecular formula :C39H62O13; molecular weight: 738.90; Ⅶ, CAS number: 76296-75-8; molecular formula: C51H84O22; molecular weight: 1049.22 were purchased from Shanghai Yuanye Biological Technology Co., Ltd.

[0029] 1.2 Test strain: The standard strain of Malassezia furfur (CBS1878) was purchased from the Medical Fungi Collection Center of the Institute of Dermatology, Chinese Academy of Medical Sciences, and Malassezia furfur was inoculated on Sabouraud medium containing rapeseed oil and...

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Abstract

The invention relates to the technical field of bacterium prevention of microorganisms, in particular to application of polyphyllin in products for resisting malassezia fufur and candida albicans. Itis discovered that in-vitro drug sensitivity tests by an inventor that polyphyllin has an inhibition effect on malassezia fufur and candida albicans. The weight fraction of polyphyllin I, VI and VII and MIC, with an inhibition effect on malassezia fufur, of rhizoma paridis total saponin is 2 mug/mL, 19 mug/mL, 39 mug/mL and 0.5 mug/mL; The weight fraction of polyphyllin I, II, VI and VII and MIC,with an inhibition effect on candida albicans, of rhizoma paridis total saponin is 0.125 mug/mL, 0.03125 mug/mL, 78 mug/mL, 0.625 g/L and 0.5 g/L. Compared with an existing bacteriostat, polyphyllin has small MIC value on malassezia fufur and candida albicans and has good antimicrobial activity. Polyphyllin can be used as an antimicrobial active component and added to external medicine, oral medicine, a disinfectant, a washing agent and an antimicrobial coating and has the functions of inhibiting growth of malassezia fufur and candida albicans.

Description

Technical field [0001] The invention relates to the technical field of microbial antibacterial technology, and in particular to the application of saponins of saponins from the anti-Malassezia furfur and Candida albicans products. Background technique [0002] Malassezia furfur and Candida albicans are two common pathogenic fungi in clinical practice. Malassezia furfur is one of the normal flora that parasitize the human body and can cause disease under certain conditions. Due to its broad pathogenic spectrum, it has received increasing attention. The diseases currently identified as related to Malassezia pityriasis infection include pityriasis versicolor, Malassezia pityriasis folliculitis, seborrheic dermatitis, atopic dermatitis and so on. Candida albicans is also a conditional pathogen. It often invades the skin and mucous membranes, and can also cause internal organs or systemic infections. The fungal diseases caused by it are collectively referred to as candidiasis. Its cl...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P31/10A01N43/16A01P3/00
CPCA01N43/16A61K31/7048A61P31/10
Inventor 孙东杰朱纹懿黄云丽王奇飒李国星
Owner FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
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