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A five-layer blood perfusion device and blood perfusion method

A technology of hemoperfusion and adsorption layer, which is applied in the direction of blood filtration, etc., can solve the problems of single adsorbent and poor effect of hemoperfusion treatment, etc., and achieve the effect of comprehensive blood purification and good purification effect

Active Publication Date: 2021-06-25
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, the adsorbent in the existing hemoperfusion device is relatively simple, which is difficult to meet the use of severe blood diseases such as renal failure, and the effect of hemoperfusion therapy is poor

Method used

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  • A five-layer blood perfusion device and blood perfusion method

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example 1

[0030] Example 1: The volume of the gel microsphere anticoagulant layer is 60 mL, the diameter of the heparan gel microsphere is 300 microns, polyethersulfone is used as the high molecular polymer A, and acrylic acid and styrene sulfonic acid are used as monomers. The rate is 0.1%, the APTT time is 250s, and the TT time is 70s.

example 2

[0031] Example two: the volume of the gel microsphere anticoagulant layer is 60mL, the diameter of the heparan gel microsphere is 500 microns, polyethersulfone is used as the polymer A, and acrylic acid and styrene sulfonic acid are used as monomers, the hemolysis The rate was 0.1%, the APTT time was 220s, and the TT time was 65s.

example 3

[0032]Example 3 (optimized conditions): the volume of the anticoagulant layer of gel microspheres is 80 mL, the diameter of heparan gel microspheres is 300 microns, polyethersulfone is used as polymer A, and acrylic acid and styrene sulfonic acid are used as monolayers. body, the hemolysis rate was 0.1%, the APTT time was 300s, and the TT time was 80s.

[0033] Further, the β2 microglobulin adsorption layer is filled with several porous cellulose microspheres modified with hexadecyl hydrophobic chains; the volume of the β2 microglobulin adsorption layer is 40-80mL; The diameter of the porous cellulose microspheres modified by hexadecyl hydrophobic chains is 400-500 μm.

[0034] In order to better adsorb the β2 microglobulin in the blood; the β2 microglobulin adsorption layer of the present invention is filled with several porous cellulose microspheres modified with hexadecyl hydrophobic chains; preferably, ten Porous cellulose microspheres modified with hexadecyl hydrophobic ...

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Abstract

The invention belongs to the technical field of blood purification, and discloses a five-layer hemoperfusion device and a hemoperfusion method. Coagulation layer, β2 microglobulin adsorption layer, urea decomposition layer, ammonia adsorption layer and activated carbon adsorption layer. The hemoperfusion method comprises the steps of sequentially passing blood through a gel microsphere anticoagulation layer, a β2 microglobulin adsorption layer, a urea decomposition layer, an ammonia adsorption layer and an active carbon adsorption layer. The invention has the characteristics of comprehensive blood purification and good purification effect.

Description

technical field [0001] The invention belongs to the technical field of blood purification, and in particular relates to a five-layer hemoperfusion device and a hemoperfusion method. Background technique [0002] In the medical field, for the treatment of acute and chronic drug poisoning, uremia and other diseases, hemoperfusion is generally used. The method is to introduce the patient's blood into the dialyzer through the pipeline, so that the blood can be purified through the adsorption of the adsorbent in the dialyzer, and the blood after dialysis is returned to the body through the pipeline, so as to remove the large and medium molecular toxins in the blood and achieve therapeutic effect. the goal of. [0003] The instrument used in the general hemoperfusion method is a hemoperfusion device. Hemoperfusion is currently mainly used in the adsorption of acute and chronic drug poisoning, molecular toxins in uremia, and pathogenic factors in the field of liver disease and im...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/34
CPCA61M1/34
Inventor 赵长生赵伟锋张珏宋昕纪海锋魏然王艺霖钱一晖
Owner SICHUAN UNIV
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