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Five-layer blood perfusion device and blood perfusion method

A hemoperfusion device and hemoperfusion technology, which is applied in the field of five-layer hemoperfusion device and hemoperfusion, can solve the problems of single adsorbent and poor effect of hemoperfusion treatment, and achieve the effect of comprehensive blood purification and good purification effect

Active Publication Date: 2019-04-30
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the adsorbent in the existing hemoperfusion device is relatively simple, which is difficult to meet the use of severe blood diseases such as renal failure, and the effect of hemoperfusion therapy is poor

Method used

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  • Five-layer blood perfusion device and blood perfusion method

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Effect test

example 1

[0030] Example 1: The volume of the anticoagulant layer of gel microspheres is 60 mL, the diameter of heparinoid gel microspheres is 300 microns, polyethersulfone is used as high molecular polymer A, acrylic acid and styrene sulfonic acid are used as monomers, and the hemolysis The rate was 0.1%, the APTT time was 250s, and the TT time was 70s.

example 2

[0031] Example 2: The volume of the anticoagulant layer of gel microspheres is 60 mL, the diameter of heparinoid gel microspheres is 500 microns, polyethersulfone is used as high molecular polymer A, and acrylic acid and styrene sulfonic acid are used as monomers. The rate was 0.1%, the APTT time was 220s, and the TT time was 65s.

example 3

[0032]Example 3 (preferred conditions): the volume of the anticoagulant layer of gel microspheres is 80 mL, the diameter of heparinoid gel microspheres is 300 microns, polyethersulfone is used as high molecular polymer A, and acrylic acid and styrene sulfonic acid are used as monolayers. The hemolysis rate was 0.1%, the APTT time was 300s, and the TT time was 80s.

[0033] Further, the β2 microglobulin adsorption layer is filled with several porous cellulose microspheres modified with hexadecyl hydrophobic chains; the volume of the β2 microglobulin adsorption layer is 40-80 mL; The diameter of the hexadecyl hydrophobic chain-modified porous cellulose microspheres is 400-500 μm.

[0034] In order to better adsorb β2 microglobulin in blood; the β2 microglobulin adsorption layer of the present invention is filled with several porous cellulose microspheres modified with hexadecyl hydrophobic chains; Porous cellulose microspheres modified with hexadecyl hydrophobic chains were pro...

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Abstract

The invention belongs to the technical field of blood purification, and discloses a five-layer blood perfusion device and a blood perfusion method. The blood perfusion device comprises a perfusion device body, and a gel microsphere anticoagulant layer, a beta-2 microglobulin adsorption layer, a urea decomposition layer, an ammonia adsorption layer and an activated carbon adsorption layer are arranged in the perfusion device body in the direction of blood flow. The blood perfusion method comprises the steps of allowing blood to successively pass through the gel microsphere anticoagulant layer,the beta-2 microglobulin adsorption layer, the urea decomposition layer, the ammonia adsorption layer and the activated carbon adsorption layer. The five-layer blood perfusion device and the blood perfusion method have the advantages of comprehensive blood purification and good purification effect.

Description

technical field [0001] The invention belongs to the technical field of blood purification, in particular to a five-layer blood perfusion device and a blood perfusion method. Background technique [0002] In the medical field, for the treatment of acute and chronic drug poisoning, uremia and other diseases, the treatment method of blood perfusion is generally used. The method is to introduce the patient's blood into the dialyzer through the pipeline, so that the blood is purified by the adsorption of the adsorbent in the dialyzer, and the dialyzed blood is returned to the body through the pipeline, so as to remove the large and medium molecular toxins in the blood, and achieve treatment. the goal of. [0003] The device used in the general hemoperfusion method is the hemoperfusion device. The hemoperfusion device is currently mainly used in the adsorption of molecular toxins in acute and chronic drug poisoning, uremia, and the adsorption of pathogenic factors in the fields ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/34
CPCA61M1/34
Inventor 赵长生赵伟锋张珏宋昕纪海锋魏然王艺霖钱一晖
Owner SICHUAN UNIV
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