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A self-anticoagulation double-layer activated carbon hemoperfusion device and hemoperfusion method

A hemoperfusion and activated carbon technology, which is applied in blood filtration and other directions, can solve the problems of activated carbon shedding, poor effect, and single adsorbent, and achieve the effects of avoiding activated carbon shedding, preventing blood coagulation, and saving costs

Active Publication Date: 2021-07-30
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the adsorbent in the existing hemoperfusion device is relatively simple, which is difficult to meet the use of severe blood diseases such as renal failure, and the effect of hemoperfusion therapy is poor; the existing method of purifying blood requires a large amount of heparin to Prevent blood coagulation, and it uses polymer-embedded activated carbon for adsorption, which is easy to cause activated carbon to fall off

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] Example one: the volume of the gel microsphere anticoagulant layer is 40mL, the diameter of the heparan gel microsphere is 300 microns, MBA is the cross-linking agent, AIBN is the initiator, the chemistry of polyacrylic acid and sodium polystyrene sulfonate The ratio is 4:1, the hemolysis rate is 0.1%, the APTT time is 100s, and the TT time is 30s.

example 2

[0023] Example two: the volume of the gel microsphere anticoagulant layer is 40mL, the diameter of the heparan gel microsphere is 300 microns, MBA is the cross-linking agent, AIBN is the initiator, the chemistry of polyacrylic acid and sodium polystyrene sulfonate The ratio is 1:4, the hemolysis rate is 0.1%, the APTT time is 220s, and the TT time is 450s.

example 3

[0024] Example three (preferred conditions): the volume of the gel microsphere anticoagulation layer is 60mL, the diameter of the heparan gel microsphere is 300 microns, MBA is the cross-linking agent, AIBN is the initiator, polyacrylic acid and polystyrene sulfonate The chemical ratio of sodium bicarbonate is 1:4, the hemolysis rate is 0.1%, the APTT time is 300s, and the TT time is 80s.

[0025] Further, the activated carbon adsorption layer is filled with several polyethersulfone@activated carbon hybrid microspheres; the volume of the activated carbon adsorption layer is 80-100mL; the diameter of the polyethersulfone@activated carbon hybrid microspheres is 300-1000μm.

[0026] Activated carbon has a huge hydrophobic pore structure, which can effectively remove bilirubin, creatinine, uric acid, glycosides, phenols, guanidines, organic acids, etc. However, due to the hydrophobic and irregular surface of activated carbon and poor mechanical properties, it is easy to cause cha...

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Abstract

The invention belongs to the technical field of blood purification, and discloses a self-anticoagulant double-layer activated carbon hemoperfusion device and a hemoperfusion method. The hemoperfusion device includes a perfusion device body; A gel microsphere anticoagulant layer and an activated carbon adsorption layer; the hemoperfusion method includes the step of passing the blood through the gel microsphere anticoagulant layer and the activated carbon adsorption layer in sequence. The invention avoids the use of heparin to prevent blood coagulation and avoids the problem that the active carbon is easy to fall off caused by the way of using polymer embedding active carbon for adsorption.

Description

technical field [0001] The invention belongs to the technical field of blood purification, and in particular relates to a self-anticoagulant double-layer activated carbon hemoperfusion device and a hemoperfusion method. Background technique [0002] In the medical field, for the treatment of acute and chronic drug poisoning, uremia and other diseases, hemoperfusion is generally used. The method is to introduce the patient's blood into the dialyzer through the pipeline, so that the blood can be purified through the adsorption of the adsorbent in the dialyzer, and the blood after dialysis is returned to the body through the pipeline, so as to remove the large and medium molecular toxins in the blood and achieve therapeutic effect. the goal of. [0003] The instrument used in the general hemhemoperfusion method is a hemoperfusion device. Hemoperfusion is currently mainly used in the adsorption of acute and chronic drug poisoning, molecular toxins in uremia, and pathogenic fac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/34
CPCA61M1/34
Inventor 赵长生赵伟锋张珏宋昕纪海锋魏然王艺霖钱一晖
Owner SICHUAN UNIV
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