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Benign prostatic hyperplasia resisting urtica hyperborean Jacq extract, preparation method, and application of benign prostatic hyperplasia resisting urtica hyperborean Jacq extract

A technique for nettle extract and prostatic hyperplasia, which is applied in the field of medicine and achieves the effects of simple preparation process, high extraction rate and good therapeutic effect

Inactive Publication Date: 2019-05-03
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report on the anti-prostatic hyperplasia effect of highland nettle

Method used

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  • Benign prostatic hyperplasia resisting urtica hyperborean Jacq extract, preparation method, and application of benign prostatic hyperplasia resisting urtica hyperborean Jacq extract
  • Benign prostatic hyperplasia resisting urtica hyperborean Jacq extract, preparation method, and application of benign prostatic hyperplasia resisting urtica hyperborean Jacq extract
  • Benign prostatic hyperplasia resisting urtica hyperborean Jacq extract, preparation method, and application of benign prostatic hyperplasia resisting urtica hyperborean Jacq extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 is used for anti-benign prostatic hyperplasia plateau nettle extract and the composition comparison of other nettles

[0037] Collect 11 kinds of Urtica medicinal materials respectively, accurately weigh 1g of dried medicinal herb powder of 11 kinds of Urtica medicinal plants, put them in a 100mL round bottom flask, add 25mL of methanol, shake well, put them in a 70℃ water bath for ultrasonic extraction for 30min, and statically Keep it cold, centrifuge the supernatant, pass through a 0.45 μm microporous membrane, and set aside.

[0038] At room temperature, weigh 9 kg of dried nettle powder from plateau nettle, wet the dry coarse powder of nettle from highland with 95% ethanol, pour it into the percolation barrel, add 95% ethanol until the liquid level is higher than the surface of the medicinal material, soak overnight, Gradient percolation with 95% ethanol, 50% ethanol, and water in an amount 8-10 times the weight of the material in sequence, collecting ...

Embodiment 2

[0043] Example 2 Investigation on the Activity of Different Extracted Parts of Plateau Urtica

[0044]The present invention starts from the perspectives of plateau nettle extract on related androgen and cell proliferation. The main androgen is DHT, and excessive levels of DHT in prostate tissue can lead to benign prostatic hyperplasia. Androgens can also indirectly regulate polypeptide growth factors and their receptors, thereby regulating the growth of prostate cells. Inhibition of high expression of apoptosis factors in prostate tissue can also cause prostate hyperplasia. Prostate index and prostate histopathological detection can intuitively express the degree of benign prostatic hyperplasia. Therefore, the present invention uses detection of serum DHT and EGF levels, expression of EGF and Bcl-2 mRNA in prostate tissue, prostate index and histopathological changes of prostate as indicators to investigate the anti-prostatic hyperplasia effect of different extraction parts ...

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Abstract

The invention provides a benign prostatic hyperplasia resisting urtica hyperborean Jacq extract, a preparation method, and an application of the benign prostatic hyperplasia resisting urtica hyperborean Jacq extract. The preparation method comprises the following steps of (1) drying urtica hyperborean Jacq, performing crushing, performing extraction with 95% alcohol, performing extraction with 50%alcohol, obtaining 95% alcohol extractum, 50% alcohol extractum and aqueous extractum; (2) removing the alcohol from the urtica hyperborean Jacq extracting solution, and firstly performing degreasingwith petroleum ether to obtain a degreased extract; and (3) extracting the degreased extract with ethyl acetate, collecting part of the ethyl acetate, performing concentration, and preforming dryingto obtain the urtica hyperborean Jacq extract. The urtica hyperborean Jacq and ethyl acetate extraction positions and alcohol dissolving positions have good treatment effects on model mice suffering from benign prostatic hyperplasia, induced with testosterone propionate.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to an effective part extracted from Tibetan medicine plateau nettle with anti-prostatic hyperplasia effect, a preparation method and application thereof. Background technique [0002] Benign prostatic hyperplasia (BPH) is a common disease in middle-aged and elderly men, and its incidence increases with age. Urinary tract obstruction, even damage to renal function and other symptoms, seriously affect the normal life of patients. At present, the clinically used therapeutic drugs mainly include α-adrenoceptor blockers and 5α-reductase inhibitors. For mild and moderate BPH patients, drug therapy is mainly used, but factors such as therapeutic effect and side effects limit its application. BPH induced by subcutaneous injection of testosterone propionate is the most commonly used method. The growth and development, structure and basic physiological functions of the prostate are closely ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P13/08
Inventor 苏日娜钟国跃魏荣锐罗维早朱继孝吴依静
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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