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Fagopyrum dibotrys solution preparation for aerosol inhalation and preparation method thereof

A technology of atomized inhalation and golden buckwheat, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and medical formulas, etc., can solve the problems of non-standard use methods in the instructions and potential safety hazards in use, and achieve effective The effect of quick effect, less dosage and improved total effective rate

Inactive Publication Date: 2019-05-14
BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In clinical practice, nebulized inhalation with injection is often used, but there is no standardized method of use in the instructions, and there are potential safety hazards in use

Method used

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  • Fagopyrum dibotrys solution preparation for aerosol inhalation and preparation method thereof
  • Fagopyrum dibotrys solution preparation for aerosol inhalation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Golden buckwheat atomized inhalation solution:

[0043] Golden Buckwheat 480g

[0044] Sodium chloride 9g

[0045] Add water for injection to 1000ml

[0046] Weigh according to the above weight, add water and decoct twice for 2 hours each time, combine the filtrate, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol content reach 70%, stir well, let stand for 24h, filter, and recover the ethanol to nothing mellow. Add water until each 1ml contains 2g of medicinal materials, boil, let stand for 48 hours, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol content reach 80%, stir well, let stand for 24 hours, filter, recover the ethanol until it has no alcohol smell, Add water until every 1ml is equivalent to 2g of medicinal materials, add 0.5% activated carbon, boil for 30min, let it cool and filter, refrigerate for 24h, filter, add water for injection to 980ml, add 9g of sodium chloride, dissolve,...

Embodiment 2

[0048] Golden buckwheat atomized inhalation solution:

[0049] Golden Buckwheat 720g

[0050] Sodium chloride 6g

[0051] Add water for injection to 1000ml

[0052] Weigh according to the above weight, add water and decoct twice for 2 hours each time, combine the filtrate, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol content reach 70%, stir well, let stand for 24h, filter, and recover the ethanol to nothing mellow. Add water until each 1ml contains 2g of medicinal materials, boil, let stand for 48 hours, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol content reach 80%, stir well, let stand for 24 hours, filter, recover the ethanol until it has no alcohol smell, Add water until every 1ml is equivalent to 2g of medicinal materials, add 0.5% activated carbon, boil for 30min, let it cool and filter, refrigerate for 24h, filter, add water for injection to 980ml, add 6g of sodium chloride, dissolve,...

Embodiment 3

[0054] Golden buckwheat atomized inhalation solution:

[0055] Golden Buckwheat 360g

[0056] Glucose 100g

[0057] Add water for injection to 1000ml

[0058] Weigh according to the above weight, add water and decoct twice for 2 hours each time, combine the filtrate, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol content reach 70%, stir well, let stand for 24h, filter, and recover the ethanol to nothing mellow. Add water until each 1ml contains 2g of medicinal materials, boil, let stand for 48 hours, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol content reach 80%, stir well, let stand for 24 hours, filter, recover the ethanol until it has no alcohol smell, Add water until each 1ml is equivalent to 2g of medicinal materials, add 0.5% activated carbon, boil for 30min, let it cool and filter, refrigerate for 24h, filter, add water for injection to 980ml, add 100g glucose, dissolve, add water for i...

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Abstract

The invention belongs to the technical field of pharmaceutic preparations, and particularly relates to a fagopyrum dibotrys solution preparation for aerosol inhalation and a preparation method thereof. The fagopyrum dibotrys solution preparation for aerosol inhalation comprises fagopyrum dibotrys effective components, an isotonic agent and a solvent, wherein the fagopyrum dibotrys effective components prepared from 100-1200 g of fagopyrum dibotrys are contained in per liter of the fagopyrum dibotrys solution preparation for aerosol inhalation. According to the fagopyrum dibotrys solution preparation for aerosol inhalation, the fagopyrum dibotrys solution preparation for aerosol inhalation can quickly form aerosol through an atomizer under the synergistic action of fagopyrum dibotrys and the isotonic agent by adjusting the concentration of the fagopyrum dibotrys effective components, and the aerosol acting on an infected part can be quickly absorbed and take effect. In a word, the fagopyrum dibotrys solution preparation for aerosol inhalation is low in additive dose, quickly takes effect and is good in curative effect and free of other side and toxic effects.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a solution preparation for nebulized inhalation with the traditional Chinese medicine buckwheat as an active ingredient and a preparation method thereof. Background technique [0002] Golden buckwheat is a plant of Polygonaceae, also known as tartary buckwheat, buckwheat angelica, buckwheat notoginseng, jinsuoyinkai, etc. Functions and indications include (1) expectorant, cough, and asthma effects; (2) antibacterial effects; (3) antitumor effects; (4) antipyretic and anti-inflammatory effects; (5) blocking H1 receptor effects; (6) ) Improve the phagocytosis index of macrophages, strengthen the body's self-immune defense ability; (7) protect the chemical liver damage; (8) lower blood sugar and lower blood sugar; Hematogenous spread and metastasis of cells. It can be seen that the clinical application of golden buckwheat is wide. [0003] But at p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/70A61K9/72A61K47/02A61K47/26A61P11/06A61P11/00A61P31/04A61P11/10
Inventor 张保献胡杰
Owner BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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