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Preparation method of choline bicarbonate and carbonate
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A technology of choline bicarbonate and carbonate, applied in chemical instruments and methods, preparation of organic compounds, preparation of amino compounds, etc., to achieve the effects of mild reaction conditions, good stability, and wide application value
Active Publication Date: 2019-05-14
JINAN PENGBO BIOTECH CO LTD +1
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[0004] At present, there is no stable and mature preparation method of choline bicarbonate and carbonate announced, so a kind of preparation method of choline bicarbonate and carbonate with easy to get raw materials, stable reaction, green environmental protection and high yield needs to be developed urgently come out
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Embodiment 1
[0024] Embodiment 1: a kind of preparation of choline bicarbonate
[0025] Add 98.5kg of 30% trimethylamine aqueous solution into the reaction kettle, feed 22kg of carbon dioxide, stir while adding, the pressure is less than 2kgf / cm 2 , the cooling water was cooled to 10°C, and the reaction was kept for 2 hours to obtain trimethylammonium bicarbonate. Continue to add 22.22kg of liquefied oxirane with a concentration of 99% in the reactor, cool to 10°C, generate choline bicarbonate, filter, and obtain a 57% choline bicarbonate aqueous solution with a yield of 98.1 %.
Embodiment 2
[0026] Embodiment 2: a kind of preparation of choline carbonate
[0027] Add 197kg of 30% trimethylamine aqueous solution into the reaction kettle, feed 22kg of carbon dioxide, stir while adding, the pressure is less than 2kgf / cm 2 , temperature 10 ℃, insulation reaction 2h, to obtain trimethylammonium carbonate. Continue to add 44.44kg of liquefied oxirane with a concentration of 99% in the reactor, cool to 20°C, generate choline carbonate, filter, and obtain a 51% aqueous solution of choline carbonate with a yield of 98.4 %.
Embodiment 3
[0028] Embodiment 3: a kind of preparation of choline bicarbonate
[0029] Add 295.55kg of 40% trimethylamine aqueous solution into the reaction kettle, feed 88kg of carbon dioxide, stir while adding, the pressure is less than 2kgf / cm 2 , temperature 40 ° C, heat preservation reaction 2h, to obtain trimethylammonium bicarbonate. Continue to add 88.88kg concentration to be 99% liquefied oxirane in reactor, be cooled to 30 ℃, generate choline bicarbonate, filter, obtain concentration and be 70% choline bicarbonate aqueous solution, yield is 98.5% %.
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Abstract
The invention relates to a preparation method of cholinebicarbonate and carbonate, and belongs to the technical field of chemical synthesis. The preparation method of cholinebicarbonate and carbonate includes adding trimethylamine into water, stirring and uniformly mixing, and introducing carbon dioxide to obtain an aqueous solution of trimethylammonium bicarbonate or trimethylammonium carbonate; and adding ethyleneoxide into the above aqueous solution to generate choline bicarbonate or choline carbonate, and filtering to obtain a choline bicarbonate or choline carbonate aqueous solution. According to the method, toxic and harmful substances are not used in the production process, emission of volatile organic compounds (VOC) in the production process is eliminated, no catalyst is used,and the reaction condition is mild. The preparation method is economical, safe, green and environment-friendly, the yield is higher than 98.1%, the prepared aqueous solution has good stability, and has wide potential application value in the fields of food additives, material preparation, electrochemistry, organic synthesis and the like.
Description
technical field [0001] The invention relates to a choline salt and a preparation method thereof, in particular to a preparation method of choline bicarbonate and carbonate, belonging to the technical field of chemical synthesis. Background technique [0002] Choline (C 5 h 15 NO 2 ), also known as (2-hydroxyethyl)trimethylammonium, is an unstable organic strong base, which is widely used in food nutrition fortifiers, medicines, feed additives, and fine chemicals in the form of choline salts. Choline salts currently used mainly include choline chloride and choline bitartrate (also known as choline bitartrate). Cholinechloride is mainly reacted with trimethylaminehydrochloride and ethyleneoxide, concentrated and refined It is mainly used in the field of feed additives. Choline bitartrate is a relatively stable dibasic acid choline salt, but its production cost is relatively high, and it is currently widely used in the field of food additives. [0003] Choline bicarbona...
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