Anthraquinone compound, its preparation method and application in preparation of enzyme inhibitor

A compound and inhibitor technology, applied in the field of marine biology, can solve problems such as easy induction of drug resistance and large adverse reactions
CN109748838BActive Publication Date: 2020-04-10SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
Publication Date
2020-04-10

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Abstract

The invention discloses two novel anthraquinone compounds, namely Anthrininones B and C, as well as a preparation method and application thereof in preparing protein-tyrosine-phosphatase (PTPs) and indole-amine 2,3-dioxygenase 1 (IDO1) inhibitors, and further discloses application of 6-O-methylalaternin in preparing the PTPs and the IDO1 inhibitors, and application of Anthrininone A in preparing the IDO1 inhibitors. The compounds Anthrininones B and C have structural formulae (I) shown in the specification. The compounds Anthrininones B and C and 6-O-methylalaternin are separated from a fermentation liquid of Alternaria tenuissma JX156349, and can be applied to study on lead compounds of PTP inhibitors and DIO1 inhibitors.
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Description

technical field

[0001] The invention belongs to the field of marine biology, and in particular relates to four anthraquinone compounds and their preparation method and application in the preparation of enzyme inhibitors, in particular to the preparation of protein tyrosine phosphatase or indoleamine-2,3-diaddition Application of Oxygenase 1 Inhibitors. Background technique

[0002] At present, the diagnosis and treatment of malignant tumors is still one of the biggest challenges in the medical field. Although traditional malignant tumor treatment methods such as chemotherapy and radiotherapy have been continuously developed, they still have certain limitations and disadvantages, such as large adverse reactions and easy induction. resistance, etc. In recent years, with the deepening of tumor immunity-related research, immunotherapy has become a new hope for improving the prognosis of patients with malignant tumors. As one of many tumor immune cycle regulators, indoleamine 2...

Claims

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