Ultrasonic-magnetic resonance imaging bimodal contrast agent and preparation method and application thereof

A dual-modality contrast agent, nuclear magnetic resonance technology, applied in echo/ultrasonic imaging agents, nanomagnetism, emulsion delivery, etc., can solve the problems of multiple injections, inability to combine imaging, etc., and achieve the effect of enhancing the development function

Inactive Publication Date: 2019-05-24
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the shortcomings and deficiencies of the above existing technologies, solve the problems of multiple injections caused by a single contrast agent and the inability to perform joint imaging, etc.

Method used

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  • Ultrasonic-magnetic resonance imaging bimodal contrast agent and preparation method and application thereof
  • Ultrasonic-magnetic resonance imaging bimodal contrast agent and preparation method and application thereof
  • Ultrasonic-magnetic resonance imaging bimodal contrast agent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1) Take 0.2g of dodecafluoropentane (Shanghai Minrell Chemical) and Fe3O4 (Shanghai Maclean Biochemical, 600nm) and mix each to form the inner oil phase; dissolve 0.4g of chitosan in 40ml of water to form water phase;

[0045] (2) Mix the core oil phase and the water phase at 1200 rpm for 1 hour to form colostrum;

[0046] (3) Add 100g of liquid paraffin and 60g of Span 80 to the colostrum, stir at 1200rpm for 2h, add 0.4g of glutaraldehyde, and solidify for 3h;

[0047] (4) Let stand and settle to remove the large particles, and then wash with isopropanol and distilled water for 3-5 times, then centrifuge at 1000r / min, discard the supernatant, collect the solid particles, and freeze-dry at -20°C to obtain The ultrasound-nuclear magnetic resonance dual-modality contrast agent;

Embodiment 2

[0049] (1) Mix 0.5 g of octafluoropropane (Shanghai Myrell Chemical) and manganese tetroxide (Shanghai Macleans, 200nm) each to form the inner oil phase; dissolve 2 g of gelatin in 100 ml of water to form the water phase;

[0050] (2) Mix the inner core oil phase and the water phase and stir for 2 hours at 1000 rpm to form colostrum;

[0051] (3) Then add 300g castor oil and 200g Tween 60 to the colostrum, stir at 1000rpm for 1 hour, add 2g glutaraldehyde, and solidify for 3 hours;

[0052] (4) Let stand and settle to remove the large precipitated particles, and then wash with isopropanol and distilled water for 3 to 5 times, then centrifuge at 2000r / min, discard the supernatant, collect the solid particles, and freeze dry at -20°C to obtain Ultrasound-NMR dual-modality contrast agent.

[0053] figure 1 This is the ultrasound image of the ultrasound-NMR dual-modality contrast agent prepared in Example 1. The specific operation is: use 0.4g ultrasound-NMR dual-modality contrast agent, ...

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Abstract

The invention belongs to the field of medical preparations and discloses an ultrasonic-magnetic resonance imaging bimodal contrast agent and a preparation method and application thereof. The ultrasonic-magnetic resonance imaging bimodal contrast agent is prepared by steps: mixing an ultrasonic imaging component and a magnetic resonance imaging component to form a kernel oil phase; mixing the kernel oil phase with a water phase to form primary emulsion; adding a solvent oil phase into the primary emulsion, adding a surfactant, stirring, adding a cross-linking agent and curing; after curing is finished, standing, settling, washing, centrifuging, collecting solid and drying to obtain the ultrasonic-magnetic resonance imaging bimodal contrast agent. The ultrasonic-magnetic resonance imaging bimodal contrast agent has an imaging enhancement function in ultrasonic imaging and magnetic resonance imaging and is capable of increasing the image resolution in ultrasonic and magnetic resonance imaging.

Description

Technical field [0001] The invention belongs to the field of medical preparations, and specifically relates to an ultrasound-nuclear magnetic resonance dual-modality contrast agent and a preparation method and application thereof. Background technique [0002] The early detection of many major diseases largely depends on the development of medical imaging technology, which provides a powerful means for clinicians to obtain anatomical and physiological information. However, various medical imaging technologies have their own advantages and disadvantages in terms of imaging resolution. So far, no imaging method can obtain complete biological information. Therefore, the joint application of medical imaging has emerged. [0003] The combined application of ultrasound diagnosis and MRI has important clinical applications. Ultrasound imaging has the advantages of high sensitivity, intuitiveness, non-radiation, and real-time imaging. It also has the disadvantage of lower image resolution...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K49/18B82Y25/00
Inventor 黄岳山邓惠良劳永华兰俊
Owner SOUTH CHINA UNIV OF TECH
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