A kind of amorphous calcium phosphate-polyacrylic acid hybrid nanomaterial and its preparation method and application
A nanomaterial, crystalline calcium phosphate technology, applied in the field of biomedical materials, can solve the problems of non-degradable and poor biocompatibility, and achieve the effects of improving stability, enhancing development, and degrading quickly
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Embodiment 1
[0039] Solution preparation: weigh 240mg of Ca(NO 3 ) 2 4H 2 O and 36mg of Mg(NO 3 ) 2 ·6H 2 O was dissolved in 50 mL of deionized water, and stirred evenly to obtain a mixed solution A. Weigh 110mg of (NH 4 ) 2 HPO 4 and 40 mg of PAA were dissolved in 200 mL of deionized water, stirred evenly to obtain a mixed solution B, and ammonia water was added drop by drop to adjust the pH to 9.5.
[0040] Wet chemical precipitation: Add the mixed solution A prepared in the previous step into the mixed solution B dropwise at a rate of 1 mL / min. Stir magnetically at 500 rpm for 1 hour.
[0041] Cleaning: after the reaction, centrifuge at 4000rpm. After centrifugation, remove the supernatant, collect the precipitate, add 50 mL of deionized water, and ultrasonically disperse to obtain a dispersion.
[0042] Dialysis: Inject the dispersion into a 8000-14000Da dialysis membrane, perform dialysis for 24 hours, and change the water every 6 hours. The goal is to remove unwrapped pol...
Embodiment 2
[0046] Solution preparation: Weigh 267mg Ca(NO 3 ) 2 4H 2 O was dissolved in 50 mL of deionized water, and stirred evenly to obtain a mixed solution A. Weigh 110mg (NH 4 ) 2 HPO 4 and 40 mg of PAA were dissolved in 200 mL of deionized water, stirred evenly to obtain a mixed solution B, and ammonia water was added drop by drop to adjust the pH to 9.5.
[0047] Wet chemical precipitation: Add the mixed solution A prepared in the previous step to the mixed solution B dropwise at a rate of 1 mL / min. Stir magnetically at 500 rpm for 1 hour.
[0048] Cleaning: after the reaction, centrifuge at 4000rpm. After centrifugation, remove the supernatant, collect the precipitate, add 50 mL of deionized water, and ultrasonically disperse to obtain a dispersion.
[0049] Dialysis: Inject the dispersion into a 8000-14000Da dialysis membrane, perform dialysis for 24 hours, and change the water every 6 hours. The goal is to remove unwrapped polyacrylic acid molecules.
[0050] Drying: ...
Embodiment 3
[0052] Solution preparation: Weigh 227mg Ca(NO 3 ) 2 4H 2 O and 54mg Mg(NO 3 ) 2 ·6H 2 O was dissolved in 50 mL of deionized water, and stirred evenly to obtain a mixed solution A. Weigh 110mg (NH 4 ) 2 HPO 4 and 40 mg of PAA were dissolved in 200 mL of deionized water, stirred evenly to obtain a mixed solution B, and ammonia water was added drop by drop to adjust the pH to 9.5.
[0053] Wet chemical precipitation: Add the mixed solution A prepared in the previous step to the mixed solution B dropwise at a rate of 1 mL / min. Stir magnetically at 500 rpm for 1 hour.
[0054] Cleaning: after the reaction, centrifuge at 4000rpm. After centrifugation, remove the supernatant, collect the precipitate, add 50 mL of deionized water, and ultrasonically disperse to obtain a dispersion.
[0055] Dialysis: Inject the dispersion into a 8000-14000Da dialysis membrane, perform dialysis for 24 hours, and change the water every 6 hours. The goal is to remove unwrapped polyacrylic ac...
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