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Immune cell compositions and methods of use for treating viral and other infections

A virus infection and cell technology, applied in the field of immunotherapy for virus infection, can solve persistent infection and other problems

Pending Publication Date: 2019-06-07
MEMORIAL SLOAN KETTERING CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such viral infections can lead to persistent infection

Method used

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  • Immune cell compositions and methods of use for treating viral and other infections
  • Immune cell compositions and methods of use for treating viral and other infections
  • Immune cell compositions and methods of use for treating viral and other infections

Examples

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Embodiment Construction

[0076] The present application relates to compositions and methods for treating viral infections. Such viral infections include, but are not limited to, infection by human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), and the like. As described herein, immunostimulatory immune cells can be genetically engineered to internally express proteins that are dominant negative mutants and inhibit blockers that limit immune cell activity. By inhibiting the blocker, genetically engineered immune cells that are immunostimulatory are allowed to provide a more effective immune response against viral infection. In another embodiment, immunosuppressive cells (eg, regulatory T cells) that exhibit immunosuppressive immunoreactivity of immunostimulatory cells targeting viral antigens, such as CD8 + and / or CD4 + T cells, which can be genetically engineered to internally express proteins that are dominant negative mutants and suppress the immunosuppressive effe...

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Abstract

Disclosed herein are cells that are immune cells, which cells recombinantly express a dominant negative form of an inhibitor of a cell-mediated immune response of the immune cell, and optionally recombinantly express a chimeric antigen receptor (CAR), wherein the CAR binds to a viral antigen. In certain embodiments, the immune cell is an immunostimulatory cell, such as a T cell. In certain embodiments, the immune cell is an immunoinhibitory cell, such as a regulatory T cell. Also disclosed herein are immune cells that recognize and are sensitized to a viral antigen, which immune cells recombinantly express a dominant negative form of an inhibitor of a cell-mediated immune response of the immune cell. The cells can be sensitized to an antigen that is a viral antigen. Additionally provided are methods of using such cells to treat a viral infection in a subject in need thereof.

Description

[0001] 1. Cross references to related applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 381,219, filed August 30, 2016, and U.S. Provisional Application No. 62 / 468,881, filed March 8, 2017, each of which is incorporated herein by reference in its entirety. [0003] 2. References to Electronically Submitted Sequence Listings [0004] This application is incorporated by reference to the sequence listing attached to this application. The sequence listing is an ASCII text file created on August 22, 2017, with a size of 59,378 bytes and the title "13542-038-228_SL.TXT". 3. Field of Invention [0005] The present application relates generally to the treatment of viral infections, and more particularly to immunotherapy for the treatment of viral infections. 4. Background of the invention [0006] Viral infections are known to cause various diseases. Acute viral infection is characterized by viral replication, spread, secondary replic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/0783A61K35/17C07K14/725C07K16/28
CPCC07K14/7051C12N5/0636C12N2510/00C07K14/70503C07K14/70517C07K14/70521C07K2319/00C07K2319/03C07K2319/70C07K16/30C07K2317/622C07K2319/32C07K2319/33A61P31/12A61P31/18A61K2239/31A61K2239/46A61K39/4611A61K2239/38A61K39/464495A61K39/4636A61K39/464468A61K2239/28A61K39/4631C07K14/71C07K2319/02C12N9/22
Inventor P·S·阿杜苏米利
Owner MEMORIAL SLOAN KETTERING CANCER CENT
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