Pharmaceutical process of crocus sativus polyglycoside and its tablets

A technology of saffron and tablets, which is applied in the direction of medical preparations containing active ingredients, drug combinations, pill delivery, etc., to achieve the effects of advanced and simplified technology, high product yield, and less time-consuming

Inactive Publication Date: 2003-01-15
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report of extracting the active ingredient of saffron, total glycosides of saffron and its aglycon crocetin acid, and making tablets or injections as medicines within the search scope at home and abroad.

Method used

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  • Pharmaceutical process of crocus sativus polyglycoside and its tablets
  • Pharmaceutical process of crocus sativus polyglycoside and its tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The process of the present invention will be described in detail below through two groups of examples.

[0016] The first group of 5 embodiments is the process of extracting the original drug. After the dry stigma of saffron is taken and pulverized, it is crossed through a 20-mesh sieve, and five parts of 100 grams are placed in the Soxhlet extractor respectively. The degreasing solvent, extraction solvent and operating conditions are as follows: Table 1 shows.

[0017] As can be seen from Table 1, Example 3 has the shortest extraction time and the highest yield.

[0018] The powdery saffron total glycosides former medicine that is extracted by above-mentioned process is carried out TLC identification, according to Chinese Pharmacopoeia 90 years version one appendix 57 page test method, step is as follows: prepare test product and saffron-1-4 contrast There are five parts of the product solution, take appropriate amount of each solution, point on the same silica gel G ...

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Abstract

The present invention relates to a pharmaceutical process of saffron multiple glycoside and its tablet. Said pharmaceutical process includes the following steps: treating raw material, defatting with organic solvent, aqueous ethyl alcohol extraction and spray-drying, and its tablet-making process includes the following steps: adding auxiliary material, granulating, tabletting and coating so as to obtain the invented product for curing precordial pain due to obstruction of qi in the chest. Its production process is simple, and high in yield.

Description

[0001] The present invention is a divisional application of the invention patent with the same name "Pharmaceutical process of saffron polyglycoside and its tablet". The filing date of the original application is 941022, and the application number is 94111467.8. (1) Technical field [0002] The invention relates to a process for extracting saffron polyglycosides from plants such as saffron and preparing saffron polyglycoside tablets, and the saffron polyglycoside tablets prepared by the pharmaceutical process. (2) Background technology [0003] Iridaceae plant saffron, also known as saffron and saffron (Crocus sativus L.), is a precious medicinal material with a long history. Its stigma contains a variety of carotenoid compounds. Separation and extraction of its internal components from the stigma. As early as 1927, by Karrer, Solmssen isolated crocin-1 (Crocin-1) from the saffron stigma extract, and reported in "Indian Chemical Journal)" by Dhingra et al. in 1975, from saff...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/232A61K31/70A61P9/10
Inventor 周素娣周锦祥
Owner CHINA PHARM UNIV
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