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Directly-taken lumbricus powder decoction pieces and preparation method thereof

A ground dragon and powder technology, which is applied in the fields of pharmaceutical formulations, blood diseases, extracellular fluid diseases, etc., can solve the problems of heavy fishy smell of ground dragon decoction pieces, easy destruction of active ingredients, poor safety, etc., and achieves low fishy smell, Good patient compliance and safety

Inactive Publication Date: 2019-06-21
SICHUAN CHINESE HERBAL MEDICINES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is: to provide a preparation method of earthworm decoction pieces that can be taken directly, and to solve the problems in the prior art that the earthworm decoction pieces have heavy fishy smell, poor safety and easy destruction of active ingredients

Method used

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  • Directly-taken lumbricus powder decoction pieces and preparation method thereof
  • Directly-taken lumbricus powder decoction pieces and preparation method thereof
  • Directly-taken lumbricus powder decoction pieces and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] This embodiment discloses the investigation of the technological conditions of the Dilong decoction pieces placed in ozone water for ultrasonic washing, specifically:

[0037] Using ultrasonic time, solid-liquid ratio, and washing times as single factors, the changes of impurities and amino acid content in the ozone water washing liquid were investigated. The ozone concentration in the ozone water was 0.5 mg / L, and the results are shown in Table 1-3.

[0038] Table 1 Ultrasound time single factor investigation results table

[0039] time (min) Amino acid content (mg / g) Ash (mg / g) 0.5 12.9 2.1 1 24.45 2.8 2 26.81 2.05 4 30.72 3.05 6 35.00 2.3 8 29.18 1.95 10 22.00 2.3

[0040] It can be seen from Table 1 that the cleaning effect does not increase with the increase of ultrasonic time. When the ultrasonic time is 0.5-4 minutes, it has a good effect of removing impurities. When the ultrasonic time was 0.5 min, th...

Embodiment 2

[0049] Select three factors of solid-liquid ratio, ultrasonic time, and washing times to carry out L9(3 3 ) orthogonal test, using the total amino acid content as an index, and using SPSS18.0 software to carry out range analysis and variance analysis on the results of the orthogonal test, the factor levels of the orthogonal test are shown in Table 4-7.

[0050] Table 4 Orthogonal experimental design

[0051]

[0052] Table 5 Orthogonal test results

[0053]

[0054] Table 6 ANOVA results

[0055]

[0056] Table 7 verification test results

[0057]

[0058]

[0059] The results showed that: A 1 B 1 C 1 The best, that is, the ratio of solid to liquid is 1:10, washed with ultrasonic ozone water for 30s, and washed once. Under this condition, the total amino acid content in the washing liquid is only 10.79 mg / g, while the protein content in Dilong is 55-66%, and the total free amino acid is 8.629%, indicating that ultrasonic washing with ozone water has little...

Embodiment 3

[0061] This embodiment discloses the preparation method of the earthworm powder decoction pieces that can be taken directly of the present invention, specifically:

[0062] Step 1. Washing: wash the groundworm decoction pieces with ozone water and ultrasonically wash once, the washing conditions are solid-liquid ratio 1:5, ozone concentration 1mg / L, ultrasonic time 40s;

[0063] Step 2. Drying: Dry the Dilong decoction pieces treated in Step 1 at 50°C for 2.5 hours;

[0064] Step 3. Sterilization: use ozone to sterilize the Dilong decoction pieces processed in step 2, and the ozone concentration is 5mg / m 3 , the sterilization time is 20min;

[0065] Step 4. Pulverization: the groundworm decoction pieces sterilized in step 3 are pulverized at low temperature into a powder that can pass through a No. 6 sieve;

[0066] Step 5. Packaging: In a Class D clean area, the powder is filled with nitrogen and packed according to the packing specification of 2g / bag, the nitrogen volume con...

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Abstract

The invention discloses directly-taken lumbricus powder decoction pieces and a preparation method thereof and solves problems of strong fishy smell, low safety and proneness to damages of effective components of lumbricus decoction pieces in the prior art. The preparation method of the directly-taken lumbricus powder decoction pieces includes steps: ultrasonically washing the lumbricus decoction pieces in ozone water, drying, subjecting to ozone sterilization, grinding into powder, and packaging. The method is scientific in design and simple, and the lumbricus powder decoction pieces preparedaccording to the method can be taken directly and are high in safety, free of damages of the effective components, slight fishy smell, easily acceptable and high in compliance of patients.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine processing, and in particular relates to a powdered decoction piece of earthworm that can be taken directly and a preparation method thereof. Background technique [0002] Dilong is a precious traditional Chinese medicine recorded in the 2015 edition of "Chinese Pharmacopoeia" that has the functions of clearing away heat, calming convulsions, dredging collaterals, relieving asthma, and diuresis. Dilong is the dry body of Pheretima aspergillum (E,.Perrier), Pheretima vulgaris Chen, Pheretimaguillelmi (Michaelsen) or Pheretima ectinifera Mkhaeken of the family Pheretima aspergillum (E,.Perrier). The former is commonly called "Guangdilong", and the latter three are commonly called "Shanghaidilong". [0003] Earthworm is a commonly used animal traditional Chinese medicine, which is salty and cold in nature and belongs to the liver, spleen and bladder channels. Studies have shown...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/62A61K9/00A61P7/02A61P11/06A61P9/06A61P9/12A61P37/04A61P29/00A61P37/02A61P17/02A61P25/20A61P35/00A61L2/18
Inventor 何金泽郭力周进刘雨诗郭鼎刘娟汝任敏刘晓梅罗帅刘红梅康作为何建冉雪欢
Owner SICHUAN CHINESE HERBAL MEDICINES
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