Inertial microfluidic chip for manipulating micro-nanoparticles

A technology of micro-nano particles and microfluidic chips, which is applied in the field of microfluidics to achieve the effects of small size, improved inertial control performance, and easy production

Active Publication Date: 2019-07-05
HOHAI UNIV CHANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the fluid inertia effect has a strong dependence on the apparent size of cells, and it is difficult to precisely manipulate cells with high concentrations and similar sizes (such as separating an

Method used

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  • Inertial microfluidic chip for manipulating micro-nanoparticles
  • Inertial microfluidic chip for manipulating micro-nanoparticles
  • Inertial microfluidic chip for manipulating micro-nanoparticles

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Embodiment Construction

[0031] The preferred embodiments of the present invention will be described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described here are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

[0032] Such as figure 1 , 2 As shown, the inertial microfluidic chip proposed by the present invention is composed of an upper substrate 1 and a lower substrate 2, including a sequentially connected liquid inlet hole 3, an inlet reservoir 4, an inertial flow channel 5, an outlet reservoir 6 and Liquid outlet 7. The upper substrate 1 comprises an upper half inlet liquid reservoir 41, an upper half inertial flow channel 51, an upper half outlet liquid reservoir 61, a liquid inlet hole 3 and a liquid outlet hole 7, and the liquid inlet hole 3 and the liquid outlet hole 7 are all connected to the It is connected with the outside world for the introduction and export o...

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Abstract

The invention discloses an inertial microfluidic chip for manipulating micro-nanoparticles. The inertial microfluidic chip comprises an upper substrate and a lower substrate; the upper substrate has aliquid inlet hole, an upper half inlet reservoir, an upper half inertia flow channel, an upper half outlet reservoir and a liquid outlet hole, and the liquid inlet hole and the liquid outlet hole areall communicated with the outside; the lower substrate is provided with the lower half inlet reservoir, the lower half inertia flow channel and the lower half outlet reservoir; the upper half inlet reservoir and the lower half inlet reservoir are superposed and assembled to form the inlet reservoir, the upper half inertia flow channel and the lower half inertia flow channel are superposed and assembled to form the inertial flow channel, and the upper half outlet reservoir and the lower half outlet reservoir are superimposed and assembled to form the outlet reservoir; the liquid inlet hole issequentially communicated with the inlet reservoir, the inertia flow channel, the outlet reservoirand the liquid outlet hole; the flow channel width of the inertia flow channel is greater than the height; the inertial flow channel space structure is a curved flow channel of a stepped cross section. The chip is small in size, good in handling precision, high in flux and easy to manufacture.

Description

technical field [0001] The invention relates to an inertial microfluidic chip for manipulating micro-nano particles, which belongs to the field of micro-fluidics and can be used for precise manipulation of micro-nano biological particles, such as precise capture, focusing and separation of micro-nano biological cells. Background technique [0002] Portable real-time detection instruments have important application value in dealing with sudden on-site acute disease diagnosis, early screening and prognosis assessment of malignant diseases, and promoting the development of personalized medicine. highly valued. As the key technology of real-time detection instruments, microfluidic chips have the advantages of fast detection speed, high sensitivity, low cost, and good integration. They are very suitable for the technical needs of real-time detection and have become a research hotspot in this field. [0003] Precise manipulation of biological cells (such as capture, focusing, and...

Claims

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Application Information

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IPC IPC(8): B01L3/00
CPCB01L3/5027
Inventor 张鑫杰
Owner HOHAI UNIV CHANGZHOU
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