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Preparation method of semen plantaginis extract and application of semen plantaginis extract to preparing drugs/healthcare products for treating/preventing high uric acid-related diseases

A plantago seed extract and the technology of plantain seed, applied in the preparation of plantago seed extract and its application in the preparation of medicines/health products for the treatment/prevention of high uric acid-related diseases, can solve the problem of poor therapeutic effect, Low extraction rate, incapable of industrialization and other problems, to achieve the effect of improving side effects, simple preparation process and low cost

Inactive Publication Date: 2019-07-26
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] As a therapeutic drug candidate, plant extracts have attracted extensive attention due to their possible advantages of less side effects, but as drug candidates, plant extracts usually have problems of poor therapeutic effect and too low extraction rate to be industrialized

Method used

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  • Preparation method of semen plantaginis extract and application of semen plantaginis extract to preparing drugs/healthcare products for treating/preventing high uric acid-related diseases
  • Preparation method of semen plantaginis extract and application of semen plantaginis extract to preparing drugs/healthcare products for treating/preventing high uric acid-related diseases
  • Preparation method of semen plantaginis extract and application of semen plantaginis extract to preparing drugs/healthcare products for treating/preventing high uric acid-related diseases

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Experimental program
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preparation example Construction

[0028] In the first aspect, a preparation method of Semen Plantaginis extract is provided, comprising:

[0029] (1) dry Semen Plantaginis pulverized;

[0030] (2) Extract with 1-20L / (100g psyllium) ethanol in a water bath at 0-100°C for 0.1-10 hours, then filter and separate the filter residue and filtrate, repeat one to three times;

[0031] (3) After the filtrate of step (2) gained is combined, vacuum distillation is concentrated to 25-35mL / (100g Semen Plantaginis), and freeze-drying obtains Semen Plantaginis ethanol extract;

[0032] (4) Extracting the psyllium residue after alcohol extraction with water in a water bath at 0-100° C. for 0.1-10 hours, and then filtering to separate the filter residue and filtrate, repeating one to three times;

[0033] (5) The filtrates obtained in step (4) were combined and then concentrated to 25-35mL / (100g Semen Plantaginis) by distillation under reduced pressure, and freeze-dried to obtain Semen Plantago water extract.

[0034] Prefera...

Embodiment 1

[0063] The preparation of embodiment 1 plantago ethanol extract

[0064] Take 100g of plantain seed, grind it with a pulverizer, put it into a conical flask, and add 2L of ethanol, extract the mixture in a water bath at 60°C for 2 hours, then filter it with a 400-mesh filter, repeat the extraction experiment three times, and combine the obtained filtrates Concentrate by distillation under reduced pressure, and concentrate by lyophilizer to obtain liquid psyllium alcohol extract.

Embodiment 2

[0065] The preparation of embodiment 2 Semen Plantaginis extract

[0066] In a water bath at 85°C, use 2L of water as a solvent to extract the psyllium residue after alcohol extraction for 2 hours, and then filter under reduced pressure to separate the filter residue and filtrate. The extraction experiment is repeated three times. The resulting filtrates are combined, concentrated by vacuum distillation, and freeze-dried to obtain 7.29g of psyllium water extract, the yield is 3.65%.

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Abstract

The invention relates to an application method of a plant extract and application of the plant extract to preparing drugs / healthcare products for treating / preventing high uric acid-related diseases, particularly to a preparation method of a semen plantaginis extract and application of the semen plantaginis extract to preparing the drugs / healthcare products for treating / preventing the high uric acid-related diseases. The application method of the semen plantaginis extract and application of the semen plantaginis extract to preparing the drugs / healthcare products for treating / preventing the highuric acid-related diseases have the advantages that preparation processes of the semen plantaginis extract are simple and low in cost; ethanol and water or a mixture of ethanol and water serves as the solvent for semen plantaginis extraction to avoid the problem of pollution or residues of organic solvent and achieve safety and environmental protection; the prepared semen plantaginis extract achieves significant uric acid reducing effects and is low in side effects and can be used for preparing gout disease relieving drugs, thereby providing a new direction for improving the phenomenon of high side effects of existing gout disease treating drugs.

Description

technical field [0001] The present invention relates to a preparation method of a plant extract and its application in the preparation of medicines / health products for the treatment / prevention of hyperuric acid-related diseases, in particular to the preparation method of plantago seed extract and its application in the preparation of treatment / prevention of hyperuric acid The application of drugs / health products for related diseases. Background technique [0002] With the change of modern living habits and dietary structure, the incidence of hyperuricemia has increased. The occurrence of hyperuricemia is due to the increased production of uric acid in the body and the decreased excretion of renal uric acid, which makes the concentration of uric acid in the body higher than the dissolution capacity of the blood (>360 μmol / L). Uric acid deposits in the joints as crystals and causes recurrent attacks leading to gouty arthritis and uric acid kidney stones. These deposits an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/68A61P19/06
CPCA61K36/68A61K2236/33A61K2236/331A61K2236/39A61K2236/51A61P19/06
Inventor 雍天乔刁雪梁丹灵谢意珍吴清平
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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