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Simultaneous detection method and sensor of L-tyrosine and based on composite membrane modified electrode

A technology for modifying electrodes and detection methods, applied in the field of chemical/biological sensing

Pending Publication Date: 2019-08-02
CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, electrochemical sensors based on 3D Pt-Cu nanostructured composite films for the simultaneous detection of L-Tyr and DA have not been reported

Method used

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  • Simultaneous detection method and sensor of L-tyrosine and based on composite membrane modified electrode
  • Simultaneous detection method and sensor of L-tyrosine and based on composite membrane modified electrode
  • Simultaneous detection method and sensor of L-tyrosine and based on composite membrane modified electrode

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Embodiment Construction

[0034] All the reagents used in the examples are of analytical grade (AR), and the experimental water is all ultrapure water (resistivity ≥ 18.3 MΩ·cm). In the following description, the descriptions of amino acids all use English abbreviations.

[0035] 1. Experimental process

[0036] 1. Preparation of 3D-PtCu / CNDs / GQDs composites

[0037] Preparation of 3D-PtCu nanomaterials: (1) First take 45.3mg CuCl·2H 2 O, 26.7 mg H 2 PtCl 6 ·H 2 O and 10mL oleylamine were mixed and placed in a 25mL polytetrafluoroethylene reaction kettle; (2) Add 350mg of CTAB and mix and stir evenly in the reaction kettle; (3) Then close the device and magnetically stir in an oil bath at 170°C for 24h (4) Cool to room temperature, add excess ethanol to wash three times and centrifuge, then place the precipitate in an electric blast drying oven (60°C) and dry it into powder, and store it in the refrigerator for later use.

[0038] Acidified multi-walled carbon nanotubes (F-MWCNTs) were prepared b...

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Abstract

The invention discloses a simultaneous detection method of L-tyrosine (L-Tyr) and dopamine (DA) based on a composite membrane modified electrode. The method comprises: preparing a 3D-PtCu / CNDs / GQDs composite material; preparing a 3D-PtCu / CNDs / GQDs / GCE composite membrane modified electrode; and simulating L-Tyr and dopamine simultaneously. The results show that the modified electrode has the goodresolvable electrochemical response to the L-Tyr and DA and can be used for measurement of the L-Tyr and DA in actual samples; the lower detection limit reaches 6.4*10<-8>mol / L S / N=3) and 7.2*10<-8>mol / L (S / N=3) respectively; and thus the modified electrode has the potential application value in the field of biological analysis and detection.

Description

technical field [0001] The invention belongs to the technical field of chemical / biological sensing, and in particular relates to a method for simultaneously detecting L-tyrosine and dopamine based on a composite membrane modified electrode and a sensor. Background technique [0002] Both dopamine (DA) and L-tyrosine (L-Tyr) belong to neurotransmitters, among which dopamine in the brain is very important for goal-directed behavior and affects human emotions and behaviors. Dopamine also transmits feelings of excitement and happiness in the brain, which has also been implicated in addiction. Therefore dopamine plays an important role in the functions of human metabolism, cardiovascular, central nervous system, kidney and hormone system. Lack of dopamine can lead to many diseases, such as schizophrenia, Huntington's disease and Parkinson's syndrome. Tyrosine is the precursor of dopamine and a component of protein. Abnormal metabolism of tyrosine can cause tyrosinemia, rickets,...

Claims

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Application Information

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IPC IPC(8): G01N27/327
CPCG01N27/3277G01N27/3278
Inventor 曹忠朱钦丰赛飞刘楚周立何军意肖忠良
Owner CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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