Method for detecting alpha-fetal protein on basis of RGO-CS-Fc/Au NPs nano composite material and aptamers
A technology of nanocomposite materials and alpha-fetoprotein, applied in the field of biological detection, can solve the problems of complex operation, time-consuming technical requirements, expensive instruments, etc., and achieve the effect of small background interference
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[0045] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.
[0046] A method for detecting alpha-fetoprotein based on RGO-CS-Fc / Au NPs nanocomposite combined with a suitable ligand, the detection principle is shown in figure 1 . RGO-CS-Fc / Au NPs were modified on the surface of screen-printed electrodes by electrodeposition technology and electrostatic adsorption. The AFP aptamer was loaded on the surface of RGO-CS-Fc / Au NPs material through nanotechnology and intermolecular force, and the aptamer existed on the biosensing interface in the form of a single-chain structure due to its unstable spatial structure. After adding AFP to the biosensing interface, AFP can specifically bind to the AFP aptamer to generate a stable spatial structure, which can be arranged in an orderly manner on the electrode surface. The electrochemical signal in the PBS solution (0.2 mol / L, pH6.0) before and after AFP was detec...
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