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Process for producing bromisoval

A technology of bromidesoval and process flow, which is applied in the field of pharmaceutical production technology, can solve the problems of low purity of bromiesoval, achieve the effects of improving overall purity, reducing impurity content, and improving product quality

Inactive Publication Date: 2019-09-06
JINAN LIMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies in the prior art, the present invention provides a process flow for producing bromide solva, which solves the problem of low purity of bromide solva in the production of three-step method

Method used

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  • Process for producing bromisoval

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Embodiment 1

[0023] Such as figure 1 As shown, the embodiment of the present invention provides a kind of bromide solva production technological process, comprises the following steps:

[0024] Sp1: Oxidation process to prepare isovaleric acid;

[0025] Sp2: bromination process to prepare α-bromoisovaleryl bromide;

[0026] Sp3: the condensation process prepares the crude product of bromiesoval;

[0027] Sp4: Preparation of bromidesoval by refining process.

Embodiment 2

[0029] Such as figure 1As shown, the embodiment of the present invention provides a kind of bromidesoval production process, preferably, the container that oxidation process prepares isovaleric acid is a glass reactor and reacts, and isoamyl alcohol: potassium permanganate: Sodium carbonate: purified water: sulfuric acid = 1: 2.39: 0.68: 25.57: n is put into the glass reactor, slowly heats up at the beginning, sets the temperature of the high and low temperature circulation device to 40°C and starts the cycle, when the reaction kettle Turn off the heating after the temperature reaches 40°C, set the temperature to 10°C to cool down, start timing the reaction for 3 hours when the temperature reaches 50°C, turn off the refrigeration and start heating when the temperature starts to drop, and control the temperature of the high and low temperature circulation device to be between 60°C and 65°C Keep the temperature in the reactor below 70°C. After the reaction is completed, put the ...

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Abstract

The invention provides a process for producing bromisoval, and relates to the technical field of production processes of medicines. The process for producing bromisoval comprises the following steps:an oxidation step for preparing isovaleric acid, a bromination step for preparing alpha-bromoisovaleryl bromide, a condensation step for preparing crude bromisoval, and a refining step for preparing the bromisoval. The bromisoval is produced from isoamyl alcohol through a four-step method, so the overall purity of the product bromisoval is improved, the impurity content in the finished bromisovalis reduced, and the product quality is improved; and multiple steps are controlled, and strict quality control is adopted in every step, so the quality of the finished bromisoval is improved.

Description

technical field [0001] The invention relates to the technical field of medicine production technology, in particular to a production process of bromidesoval. Background technique [0002] Bromisoval is a urea-type sedative-hypnotic drug. Because of its good curative effect, it is still used clinically. Its preparations include tablets, injections and other compound preparations. [0003] Existing bromiesoval is manufactured by a three-step method, and isoamyl alcohol is used as a raw material for oxidation, bromination, and condensation to obtain it. However, when the three-step method was used, the purity of the finished product was relatively low, and the medical effect was relatively low. Difference. Contents of the invention [0004] (1) Solved technical problems [0005] Aiming at the deficiencies in the prior art, the invention provides a process flow for producing bromide solval, which solves the problem of low purity of the bromide solval produced by the three-st...

Claims

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Application Information

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IPC IPC(8): C07C273/18C07C275/50
CPCC07C51/16C07C51/58C07C273/1863C07C273/189C07C275/50C07C53/50C07C53/126
Inventor 杜军国秦怀国张娜
Owner JINAN LIMIN PHARMA
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