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Method for preparing astragaloside

A technology of astragaloside IV and Astragalus membranaceus, applied in the field of preparing astragaloside IV, which can solve the problems of complicated operation, long cycle, high production cost, etc.

Active Publication Date: 2019-09-06
JING BRAND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The extraction method of astragaloside IV is generally obtained by water extraction to obtain the extract of Astragalus membranaceus, and then through n-butanol extraction and macroporous adsorption resin to purify and separate saponin monomers, but this method has long cycle, complicated operation and high production cost

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The method for preparing astragaloside IV comprises the steps of:

[0039] (1), preparation of Astragalus ethanol extract:

[0040] Weigh 10 g of Radix Astragali medicinal material, grind it into powder, add 70% ethanol solution for extraction twice, and extract at 75° C. to obtain Radix Astragali extract. Among them, 100mL of ethanol solution with a volume percentage of 70% was added for the first time for extraction, and the extraction time was 2h, and 80mL of ethanol solution with a volume percentage of 70% was added for the second time for extraction, and the extraction time was 1.5h.

[0041] The astragalus extract was dried in a rotary evaporator to obtain 2.11 g of astragalus extract powder.

[0042] (2), obtaining Radix Astragali solution:

[0043] Weigh 0.32 g of astragalus extract powder and dissolve it in 7 mL of methanol, and filter through a microporous membrane with a pore size of 0.22 microns to obtain a clarified astragalus solution.

[0044] (3), ast...

Embodiment 2

[0052] The method for preparing astragaloside IV comprises the steps of:

[0053] (1), preparation of Astragalus ethanol extract:

[0054] Weigh 20g of Radix Astragali medicinal material, pulverize into powder, add 70% ethanol solution for extraction twice, the extraction temperature is 75°C to obtain Radix Astragali extract. Among them, 200mL of ethanol solution with a volume percentage of 70% was added for the first time for extraction, and the extraction time was 2h, and 160mL of ethanol solution with a volume percentage of 70% was added for the second time for extraction, and the extraction time was 1.5h.

[0055] The astragalus extract was dried in a rotary evaporator to obtain 4.3 g of astragalus extract powder.

[0056] (2), obtaining Radix Astragali solution:

[0057] Weigh 1.93 g of astragalus extract powder and dissolve it in 42 mL of methanol, and filter through a microporous membrane with a pore size of 0.22 microns to obtain a clarified astragalus solution.

[...

Embodiment 3

[0065] The method for preparing astragaloside IV comprises the steps of:

[0066] (1), preparation of Astragalus ethanol extract:

[0067] Weigh 50g of Radix Astragali medicinal material, pulverize into powder, add 70% ethanol solution for extraction twice at 75° C. to obtain Radix Astragali extract. Among them, 500mL of 70% ethanol solution by volume percentage was added for the first extraction, and the extraction time was 2h, and 400mL of 70% ethanol solution by volume percentage was added for the second extraction, and the extraction time was 1.5h.

[0068] The astragalus extract was dried in a rotary evaporator to obtain 10.80 g of astragalus extract powder.

[0069] (2), obtaining Radix Astragali solution:

[0070] Weigh 3.86g of astragalus extract powder and dissolve it in 82mL of methanol, and filter through a microporous membrane with a pore size of 0.22 microns to obtain a clarified astragalus solution.

[0071] (3), astragalus solution is carried out chromatograp...

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Abstract

The invention provides a method for preparing astragaloside, and belongs to the technical field of purification of trace components. The method for preparing the astragaloside includes the following steps that an astragalus membranaceus solution containing alcohol extract of astragalus membranaceus is placed in a high performance liquid chromatography column for elution, and when astragaloside appears, fractions of the astragaloside are collected. Through the method, the high purity astragaloside can be obtained, and the method has a short cycle and simple operation.

Description

technical field [0001] The present application relates to the technical field of separation of astragaloside IV, in particular, to a method for preparing astragaloside IV. Background technique [0002] Astragalus is a plant belonging to the genus Astragalus of the leguminous family. It is classified into Astragalus mongolica and Astragalus membranaceus. It is mainly distributed in Heilongjiang, Jilin, Inner Mongolia and other provinces, and is known as the top grade of medicine. Huang Mao is slightly warm, sweet in nature, spleen meridian, and returns to the lungs, which is beneficial for diuresis and detoxification, invigorating qi and strengthening the surface, draining pus, astringing sores and promoting granulation. Astragalus mainly contains flavonoids, saponins, polysaccharides and organic acids. Astragalus polysaccharides and saponins are the main active substances in Astragalus, and Astragalus saponins (Ⅰ-Ⅷ) are the main saponins in Astragalus. The 2015 edition of "...

Claims

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Application Information

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IPC IPC(8): C07J53/00
CPCC07J53/00
Inventor 向诗银徐剑杨跃军石万银巫岳唐万
Owner JING BRAND
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