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Pharmaceutical composition for treating oral mucosa diseases, preparing method and application

A technology of oral mucosa and composition, which is applied in the field of pharmaceutical composition and preparation for the treatment of oral mucosal diseases, can solve the problems of many medicinal flavors, high production costs, difficult to control impurity content, etc., and achieve the goal of alleviating inflammation and clear drug effect Effect

Inactive Publication Date: 2019-09-17
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned disclosed patents have good clinical efficacy in the treatment of oral lichen planus and recurrent aphthous oral ulcers, but the above-mentioned published patents have more medicinal flavors, higher production costs, and are not suitable for large-scale industrial production. It is difficult to control its impurity content, so there is an urgent need for a pharmaceutical composition with less medicinal taste and significant clinical curative effect.
At present, there is no relevant report on the treatment of oral mucosal diseases with astragalus, dandelion, and asarum.

Method used

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  • Pharmaceutical composition for treating oral mucosa diseases, preparing method and application
  • Pharmaceutical composition for treating oral mucosa diseases, preparing method and application
  • Pharmaceutical composition for treating oral mucosa diseases, preparing method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0025] (1) Raw materials: Astragalus 30g, Dandelion 30g, Asarum 20g.

[0026] (2) Preparation method:

[0027]Step 1: Weigh the crude drug according to the above weight ratio, mix all the raw materials first, add 20, 16, and 12 times of medicinal materials to extract 3 times, each time for 45 minutes, collect the filtrate, and concentrate at 70°C and 120mbar pressure.

[0028] Step 2: Cool the concentrated solution to 30°C, adjust the pH value to 3.5-4, add 8%-10% 1% chitosan (configured with 1% acetic acid solution) solution, stir until a large amount of flocculent precipitation occurs, Stand still for 2 hours, filter, and the filtrate is added with water to 1000ml to make the medicine gargle of the present invention.

Embodiment 2

[0029] The preparation of embodiment 2 pharmaceutical composition of the present invention

[0030] (1) Raw materials: Astragalus 25g, Dandelion 25g, Asarum 15g.

[0031] (2) Preparation method: after extracting, concentrating and purifying according to the preparation method in Example 1, add auxiliary materials for buccal preparations to prepare buccal tablets.

Embodiment 3

[0032] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0033] (1) Raw materials: Astragalus 25g, Dandelion 20g, Asarum 15g.

[0034] (2) Preparation method: After extracting, concentrating and purifying according to the preparation method in Example 1, it is prepared into an oral patch.

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Abstract

The invention provides a pharmaceutical composition for treating oral mucosa diseases. The pharmaceutical composition is prepared from, by weight, 5-80 parts of radix astragali, 5-80 parts of dandelion and 3-60 parts of asarum. The invention further discloses a preparing method and application of the pharmaceutical composition. The pharmaceutical composition can tonify qi and clear away toxin, clear away heat and stop pains, and eliminate swelling and promote granulation, and can treat the oral mucosa diseases and promote oral mucosa healing. The pharmaceutical composition is good in treatment effect, small in irritation, small in side effect, not prone to tolerance, low in medicine cost and suitable for large-scale use and popularization, has broad medical prospects, and provides a novel medication option for clinically treating the oral mucosa diseases such as erosive oral lichen planus and recurrent aphthous ulcer.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a pharmaceutical composition for treating oral mucosal diseases, a preparation method and application. Background technique [0002] Oral mucosal disease is oral mucosal disease, which is a disease that changes the normal color, shape, integrity and function of the mucosa in a certain part of the oral cavity. , affecting speech and eating, often makes patients miserable. In more serious cases, some oral mucosal diseases may lead to the occurrence of some oral malignant lesions if not treated in time. In addition, many systemic diseases are often manifested in the oral mucosa, and the lesions of the oral mucosa are often an important basis for early detection and early diagnosis of these diseases. Oral mucosal diseases mainly include recurrent recurrent aphthous oral ulcers, Behcet's disease, lichen planus and oral leukoplakia. Although the clinical manifestations of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P1/02
CPCA61K36/268A61K36/288A61K36/481A61P1/02A61K2300/00
Inventor 左渝陵金钊艾黄萍郑涛严航
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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