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Flexible extendable nerve electrode and preparation method and application thereof

A nerve and electrode technology, applied in the field of nerve electrodes, can solve problems such as the inability to guarantee biocompatibility and chemical stability, the inability to ensure reliable measurement of EEG signals, the degradation or corrosion of liquid metal electrodes, etc., and achieve easy mass production and Optimized design, good biocompatibility, low cost effect

Inactive Publication Date: 2019-09-20
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN105944228B discloses the use of liquid metal directly sprayed on the polymer substrate to package and manufacture nerve electrodes, but there are still many disadvantages. On the one hand, the precision of the liquid metal direct spray method cannot be accurately controlled, and the size of the nerve electrodes is large, which cannot guarantee the accuracy of EEG signals. Reliable measurement; on the other hand, in complex body fluid environments, liquid metal electrodes are prone to degradation or corrosion, and biocompatibility and chemical stability cannot be guaranteed

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  • Flexible extendable nerve electrode and preparation method and application thereof
  • Flexible extendable nerve electrode and preparation method and application thereof
  • Flexible extendable nerve electrode and preparation method and application thereof

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Embodiment 1

[0057] The present invention provides a flexible and stretchable nerve electrode. The flexible and stretchable nerve electrode includes a flexible polymer material, a liquid metal electrode embedded in the flexible polymer material, and an insulating material; the liquid metal electrode includes a wire, The electrode sites and the external interface end are respectively located at the two ends of the wire; the insulating material covers the wire and the external interface end of the liquid metal electrode. Its preparation method is:

[0058] (1) Weigh 3g of gallium-indium alloy and add it to 1mL of absolute ethanol, use an ultrasonic cell disruptor to sonicate for 2min at an amplitude of 20%, the liquid metal is converted into micro-nano particles under the action of ultrasound, and a suspension of liquid metal particles is prepared; SEM observation of the liquid metal particles, such as figure 1 As shown, it can be seen from the figure that the particle size distribution of ...

Embodiment 2

[0065] The present invention provides a flexible and stretchable nerve electrode. The flexible and stretchable nerve electrode includes a flexible polymer material, a liquid metal electrode embedded in the flexible polymer material, and an insulating material; the liquid metal electrode includes a wire, The electrode sites and the external interface end are respectively located at the two ends of the wire; the insulating material covers the wire and the external interface end of the liquid metal electrode. Its preparation method is:

[0066] (1) Weigh 3g of gallium-indium alloy and add it to 1mL of n-decyl alcohol, and use an ultrasonic cell disruptor to sonicate for 3 minutes at an amplitude of 30%, and the liquid metal is converted into micro-nano particles under the action of ultrasound, and a suspension of liquid metal particles is prepared; SEM observation of the liquid metal particles, such as Figure 7 As shown, it can be seen from the figure that the particle size of ...

Embodiment 3

[0072] The present invention provides a flexible and stretchable nerve electrode. The flexible and stretchable nerve electrode includes a flexible polymer material, a liquid metal electrode embedded in the flexible polymer material, and an insulating material; the liquid metal electrode includes a wire, The electrode sites and the external interface ends are respectively located at the two ends of the wire; the insulating material covers the wire and the external interface end of the liquid metal electrode. Its preparation method is:

[0073] (1) Weigh 3g of gallium-indium alloy and add it to 1mL DMF, use an ultrasonic cell disruptor to sonicate for 3min at 30% amplitude, the liquid metal is converted into micro-nano particles under the action of ultrasound, and a liquid metal particle suspension is prepared; liquid metal The particle size distribution of the particles is 500nm-1800nm.

[0074] (2) Using CAD to design the mask plate of the neural electrode pattern, the patter...

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Abstract

The invention relates to a flexible extendable nerve electrode and a preparation method and application thereof. The flexible extendable nerve electrode comprises a flexible polymer material, a liquid metal electrode embedded in the flexible polymer material and an insulation material; the liquid metal electrode includes a lead, an electrode site and an external interface end, and the electrode site and the external interface end are respectively located at two ends of the lad; the insulation material covers the lead and the external interface end of the liquid metal electrode. The flexible extendable nerve electrode has good biocompatibility, high conductivity and excellent tensile properties, and these properties can be long-term and stable; the preparation method has the advantages of high machining accuracy, strong design flexibility, simple process, low cost and easy mass production and optimized design of nerve electrodes.

Description

technical field [0001] The invention relates to the technical field of nerve electrodes, in particular to a flexible and stretchable nerve electrode and its preparation method and application. Background technique [0002] Brain-Machine / Computer Interface (BMI / BCI) refers to building a communication and control bridge between the brain and external electronic equipment, and realizing the connection between the human brain and the machine through the collection and decoding of neural electrophysiological signals. communication between. Brain-computer interface technology is not only of great significance for the diagnosis and mechanism research of cranial nerve diseases, but also has broad application prospects in emergency relief, industrial production and even military science. At present, the acquisition methods of EEG signals are mainly divided into two types: invasive and non-invasive. Compared with non-invasive acquisition methods such as scalp EEG, invasive signal acq...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/0478B22F9/06B41M1/12B41M5/00H01B1/22H01B13/00
CPCA61B2562/0209A61B2562/125A61B5/291B22F9/06B41M1/12B41M5/00B41M5/0047H01B1/22H01B13/00
Inventor 蒋兴宇董瑞华刘晓艳唐立雪
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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