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Nutritional compositions with partially hydrolysed proteins for use in inducing glucose and/or insulin response(s) close to the ones observed with human milk

A nutritional composition, a technology for hydrolyzing whey protein, applied in the directions of hydrolyzed protein ingredients, medical preparations containing active ingredients, peptide/protein ingredients, etc.

Inactive Publication Date: 2019-09-20
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many studies have shown that infant formula does not induce the same effects on the body as human breast milk

Method used

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  • Nutritional compositions with partially hydrolysed proteins for use in inducing glucose and/or insulin response(s) close to the ones observed with human milk
  • Nutritional compositions with partially hydrolysed proteins for use in inducing glucose and/or insulin response(s) close to the ones observed with human milk
  • Nutritional compositions with partially hydrolysed proteins for use in inducing glucose and/or insulin response(s) close to the ones observed with human milk

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0168] Table 1 below gives an example of the composition of a nutritional composition (eg infant formula) according to the present invention. This composition is given by way of illustration only.

[0169] Nutrients per 100kcal per liter Energy (kcal) 100 670 Protein (g) (100% partially hydrolyzed whey protein) 1.83 12.3 Fat (g) 5.3 35.7 Linoleic acid (g) 0.79 5.3 α-linolenic acid (mg) 101 675 Lactose (g) 11.2 74.7 Minerals (g) 0.37 2.5 Sodium (mg) 23 150 Potassium (mg) 89 590 Chlorine (mg) 64 430 Calcium (mg) 62 410 Phosphorus (mg) 31 210 Magnesium (mg) 7 50 Manganese (μg) 8 50 Selenium (μg) 2 13 Vitamin A (μg RE) 105 700 Vitamin D (μg) 1.5 10 Vitamin E (mg TE) 0.8 5.4 Vitamin K1 (μg) 8 54 Vitamin C(mg) 10 67 Vitamin B1(mg) 0.07 0.47 Vitamin B2(mg) 0.15 1.0 Niacin (mg) 1 6.7 Vitamin B6(mg) 0.075 0.5...

Embodiment 2

[0172] Clinical Study Description

[0173] The proposed study is a randomized, double-blind, single-centre, crossover study with four study products.

[0174] Product 1: Breast milk (BM group)

[0175] Product 2: Complete protein formula (70% whey / 30% casein, 1.88g protein / 100kcal) (INTACT group)

[0176] Product 3: Partially hydrolyzed whey protein (1.96g / 100kcal) (PHw group)

[0177] Product 4: Higher concentration (2.8g / 100kcal) post-discharge formula for premature infants with partially hydrolyzed whey protein (DISCH group)

[0178] See Table 2 below for the detailed composition of the 3 formulas.

[0179] Thirty-four adult volunteers (male and female) with normal body weight (BMI 19-25 kg / m2) were recruited for the study. For ethical reasons, it was also chosen to conduct the study in adults (rather than infants). Although the absolute values ​​of the glucose and insulin responses to the test products may differ between adults and infants, the relative differences ...

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Abstract

The present invention relates to a nutritional composition comprising from 1.5 to 2.3 g / 100 kcal of partially hydrolysed whey proteins for use in infants or young children in promoting a glucose and / or an insulin response(s) that is / are similar to the glucose and / or insulin response(s) of infants or young children fed predominantly or exclusively with human breast milk or with intact proteins.

Description

technical field [0001] The present invention relates to nutritional compositions for infants or young children and their health effects. In particular, it relates to infant formulas comprising partially hydrolyzed proteins for inducing glucose and insulin responses close to / similar to those of infants fed primarily or exclusively with human breast milk (HBM). Background technique [0002] Evidence suggests that infancy may be a critical period for developing metabolic disorders. Breastfeeding is recommended for all infants. However, in some cases, breastfeeding is not sufficient or successful, or the mother does not choose to breastfeed, for some medical reason. Nutritional compositions, such as infant formulas, have been developed for these conditions. [0003] Nutritional compositions for infants and young children are usually sold as powders for reconstitution with water or in some cases as ready-to-drink or concentrated liquid compositions. These compositions are int...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/00A61K38/01A23L33/18
CPCA61K38/018A23L33/18A23L33/40A23V2002/00A23L33/135A23L33/19
Inventor Y·沙卡利里杜卢C·梅斯
Owner SOC DES PROD NESTLE SA