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Hydroxyapatite-containing injection filling preparation and preparation method thereof

A hydroxyapatite and preparation technology, which is applied in the fields of medical cosmetology and biomedicine, can solve problems such as migration, difficulty in forming, and inability to achieve cosmetic effects, and achieve the effects of preventing migration, improving durability, and promoting skin cell growth

Inactive Publication Date: 2019-10-01
王月玲 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But hydroxyapatite itself is very brittle, not easy to form, slightly soluble in water
Hydroxyapatite is absorbed in the body for about 3 months, and may migrate, resulting in failure to achieve the desired cosmetic effect

Method used

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  • Hydroxyapatite-containing injection filling preparation and preparation method thereof
  • Hydroxyapatite-containing injection filling preparation and preparation method thereof
  • Hydroxyapatite-containing injection filling preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Weigh 55 parts of hydroxyapatite, pulverize and grind into microspheres of 25-45 μm; add 3 parts of sodium carboxymethylcellulose and 3.9 parts of mannitol to the ground hydroxyapatite microspheres, continue to grind evenly, and Add the ground mixed material to 100 parts of phosphate buffer solution with a pH of 6.5, stir for 3 hours under negative pressure (-0.02Mpa), discharge the material, fill it into a 2.25ml pre-filled syringe, and extinguish it by gamma ray irradiation. bacteria.

Embodiment 2

[0034] Weigh 40 parts of hydroxyapatite, pulverize and grind it into microspheres of 10-20 μm; add 1 part of carbomer, 2 parts of triethanolamine, and 5 parts of glycerin to the ground hydroxyapatite microspheres, and continue to grind evenly. Add the ground mixed material to 100 parts of phosphate buffer solution with a pH of 5.5, stir for 5 hours under negative pressure (-0.05Mpa), discharge the material, fill it into a 2.25ml prefilled syringe, and irradiate it with gamma rays Sterilize.

Embodiment 3

[0036] Weigh 65 parts of hydroxyapatite, pulverize and grind into microspheres of 50-70 μm; add 5 parts of hydroxypropyl methylcellulose and 2 parts of mannitol to the ground hydroxyapatite microspheres, continue to grind evenly, and The ground mixture was added to 100 parts of 0.9% sodium chloride solution, stirred for 5 hours under negative pressure (-0.07MPa), discharged, filled into a 2.25ml prefilled syringe, and sterilized by gamma ray irradiation.

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Abstract

The invention relates to a hydroxyapatite-containing injection filling preparation and a preparation method thereof, and belongs to the technical field of medical cosmetology and biomedical treatment.The hydroxyapatite-containing injection filling preparation is prepared from, by weight, 20-80 parts of hydroxyapatite, 1-20 parts of a gel substrate, 1-20 parts of an osmotic pressure regulating agent and 100 parts of a buffer salt solution. By using the hydroxyapatite-containing injection filling preparation prepared by using the method, the resistance time of the hydroxyapatite in vivo can beprolonged, hydroxyapatite particles are prevented from migrating on an injection site, the durability of hydroxyapatite microspheres on the injection site is improved, the irritation to tissue is low,after injection, the most natural effect can be achieved, the tissue of the injection site is soft, no indurations are caused, granuloma response is difficult to cause, and blemishes on skin can be quickly filled and lubricated.

Description

technical field [0001] The invention belongs to the technical fields of medical cosmetology and biomedicine, and in particular relates to an injection filling preparation containing hydroxyapatite and a preparation method thereof. Background technique [0002] It has become a common phenomenon to correct soft tissue defects and repair aging and wrinkled skin through plastic surgery technology, so as to maintain the perfect and youthful facial shape. Among various plastic surgery techniques, injection beauty technology accounts for the largest proportion, accounting for about 40% of the entire beauty market. Injection beauty technology is a beauty technology that partially modifies the human body through injection to achieve exquisite local shape and harmonious overall shape. This technology has the characteristics of zero recovery, quick effect and high safety, and is the first choice for beauty needs. [0003] Injection cosmetology is a kind of non-surgical plastic cosmet...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/16A61L27/12A61L27/50A61L27/52A61L27/58
CPCA61L27/12A61L27/16A61L27/20A61L27/50A61L27/52A61L27/58A61L2400/06C08L1/286C08L1/284C08L33/02
Inventor 王月玲
Owner 王月玲
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