Application of levo-propranolol in preparing medicament for treating vasculopathy

A vascular disease and drug technology, applied in the field of medicine, can solve problems such as poor resistance, low dosage, and difficulty in accurately controlling dosage.

Pending Publication Date: 2019-10-11
武汉恒信源药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Pre-treatment evaluation Although propranolol has been widely proven to have significant curative effects and few serious adverse reactions, there are still a small number of children who may experience drowsiness or insomnia, decreased appetite, bradycardia, hypotension, hypoglycemia, etc. Adverse symptoms of arrhythmia, especially when applied to younger infants, so it is particularly important to develop drugs with better efficacy or fewer side effects
[0006] In addition, most of the patients are infants and young children, with the characteristics of very little dosage and poor resistance. Usually, a tablet is divided into multiple doses, and it is difficult to accurately control the dosage; and there are gastrointestinal reactions, which affect the curative effect and cannot meet the current clinical requirements. need

Method used

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  • Application of levo-propranolol in preparing medicament for treating vasculopathy
  • Application of levo-propranolol in preparing medicament for treating vasculopathy
  • Application of levo-propranolol in preparing medicament for treating vasculopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] The prescription consists of:

[0076]

[0077] Taking the production of 1000 L-propranolol tablets as an example, the specific preparation method is to pass the main material and auxiliary materials through a 100-mesh sieve, weigh the prescribed amount of L-propranolol and PEG6000, and put the pregelatinized starch into the preparation method respectively. In the granulator, dry mix for 6-8 minutes, add 45% ethanol of the prescribed amount to moisten, then move to the boiling dryer to dry to 3-6% moisture; after that, pass through a 25-mesh sieve for granulation, add magnesium stearate, and press into tablets. Instantly.

Embodiment 2

[0079] The prescription consists of:

[0080]

[0081] Taking levopropranolol oral emulsion as an example, the specific preparation method is: take levopropranolol, dissolve it with 1 / 9 purified water, add carboxymethyl cellulose to 1 / 5 amount of purified water, Prepare the water phase; dissolve the prescribed amount of soybean lecithin in corn oil to form the oil phase; heat both the water phase and the oil phase at 72°C, add the water phase to a high-speed shearing machine, and slowly add the oil phase and the remaining Purified water, 6000r / min, 5min, to prepare crude milk; transfer the above crude milk to a high-speed homogenizer, emulsify at 4000rpm for 10min, fill, sterilize, and obtain.

Embodiment 3

[0083] The prescription consists of:

[0084]

[0085] Taking the preparation of levopropranolol oral emulsion as an example, the specific preparation method is: weigh levopropranolol, dissolve it with 1 / 10 purified water, add gum arabic to 1 / 4 amount of purified water, and prepare water Phase; Dissolve the egg yolk phospholipid in sesame oil in the prescribed amount to form the oil phase; heat both the water phase and the oil phase at 72°C, add the water phase to a high-speed shearing machine, slowly add the oil phase and the remaining purified water while stirring at a high speed, 6000r / Min, 10min, to prepare crude milk; transfer the above crude milk to a high-speed homogenizer, emulsify at 3500rpm for 10min, fill, sterilize, and obtain.

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PUM

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Abstract

The invention provides application of levo-propranolol in preparing a medicament for treating vasculopathy. During treatment of vasculopathy, particularly treatment of hemangioma, the treatment effectof the levo-propranolol is better than those of racemic propranolol and dextro-propranolol, and a good prospect is provided for the clinical treatment of hemangioma or infantile hemangioma.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of L-propranolol in the preparation of medicines for treating vascular diseases. Background technique [0002] Vascular disease refers to diseases caused by changes in the shape and performance of blood vessels, which lead to the impact of vascular function. Hemangioma, also known as infantile hemangioma, is a congenital vascular disease, which is more common at birth or shortly after birth, and can occur in any part of the body. The incidence rate in newborns is 2% to 3%. The incidence rate is about 10% in the following children, and the incidence rate in premature infants or low birth weight neonates can be as high as 22% to 30%. , with an increasing trend year by year. Although most hemangiomas can regress on their own, some hemangiomas will still proliferate rapidly. About 10% of hemangiomas grow rapidly. If not actively treated, various complications may o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/138A61P9/00A61P35/00
CPCA61K31/138A61P9/00A61P35/00
Inventor 李宏
Owner 武汉恒信源药业有限公司
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