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Insulin a-chain derived peptide fragment and pharmaceutical composition for preventing or treating diabetes or diabetic wounds, containing same

A composition and drug technology, applied in the directions of medical preparations containing active ingredients, peptides, tripeptide components, etc., can solve the problems of long time, inconvenient use, high cost, etc., and achieve increased mobility and proliferation, and increased glucose intake. , the effect of simple preparation

Active Publication Date: 2019-10-11
SUPADELIXIR INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] On the other hand, the existing insulin preparations are used in the form of injections because they are high-molecular-weight protein preparations, which are inconvenient to use, and more attention must be paid to the storage and handling of the preparations
Moreover, in order to prepare high-purity insulin, it needs to spend a lot of money in the production and refining process, and it takes a long time

Method used

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  • Insulin a-chain derived peptide fragment and pharmaceutical composition for preventing or treating diabetes or diabetic wounds, containing same
  • Insulin a-chain derived peptide fragment and pharmaceutical composition for preventing or treating diabetes or diabetic wounds, containing same
  • Insulin a-chain derived peptide fragment and pharmaceutical composition for preventing or treating diabetes or diabetic wounds, containing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1. Synthesis of Peptides

[0055] Peptides of SEQ ID NO: 1 to 6 (see Table 1 below) were synthesized by the FMOC solid-phase method using an automated synthesizer (PeptrEx-R48, Peptron, Daejeon, Republic of Korea). The synthesized peptides were refined and analyzed by reverse-phase HPLC (Prominence LC-20AB, Shimadzu Corporation, Japan) using a C18 analytical RP column (Shiseido capcell pak). Instrument (HP 1100Series LC / MSD, Hewlett-Packard Company, Roseville, USA) was identified.

[0056] [Table 1]

[0057] Peptide name SEQ ID NO amino acid sequence IDP1 SEQ ID NO: 1 Cys-Ser-Leu-Tyr IDP2 SEQ ID NO: 2 Tyr-Gln-Leu-Glu IDP3 SEQ ID NO: 3 Cys-Ser-Leu IDP4 SEQ ID NO: 4 Ser-Leu-Tyr IDP5 SEQ ID NO: 5 Tyr-Gln-Leu IDP6 SEQ ID NO: 6 Gln-Leu-Glu

Embodiment 2

[0058] Example 2. Preparation of compositions comprising peptides

[0059] The peptides of SEQ ID NO: 1 to 6 were each dissolved in PBS and prepared so that the concentration became 1M. The obtained protein solutions were used in the following test examples.

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Abstract

Provided in the present invention are an insulin A-chain derived peptide fragment and a pharmaceutical composition for preventing or treating diabetes or diabetic wounds, containing the same as an active ingredient. The peptide of the present invention induces endocytosis through insulin receptors, has activities of increasing glucose uptake of cells by translocating glucose transporters onto a cell membrane, and of increasing cell migration and proliferation. Therefore, the peptide of the present invention can be usefully applicable in the prevention or treatment of diabetes or diabetic wounds.

Description

technical field [0001] The present invention discloses a peptide fragment derived from insulin A-chain and a pharmaceutical composition containing it as an active ingredient for preventing or treating diabetes or diabetic wounds. Background technique [0002] Insulin is a peptide hormone secreted by beta cells of pancreatic islets. Insulin promotes fat, liver and skeletal muscle cells to take up glucose from the blood to regulate the metabolism of carbohydrates, fats and proteins. The human insulin protein consists of 51 amino acids and has a molecular weight of 5808 Da. Insulin is a dimer of A chain and B chain and are interconnected by disulfide bonds. [0003] Diabetes mellitus is a metabolic disease characterized by decreased insulin secretion, decreased glucose utilization, or increased glucose production leading to elevated blood glucose levels. Diabetes causes various complications such as diabetic wounds such as diabetic foot ulcers. Currently, human insulin prep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/083C07K5/103A61K38/06A61K38/07
CPCA61K38/06A61K38/07A61K38/00C07K5/081C07K5/0812C07K5/0819C07K5/1013C07K5/1016C07K5/0808
Inventor 韩长熙金昌兼
Owner SUPADELIXIR INC
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