Method for creating animal pharmacokinetic model for drug multi-peak phenomenon

Abstract

The invention relates to a method for creating an animal pharmacokinetic model for a drug multi-peak phenomenon. The method includes the following steps: selecting at least 6 dogs with three male dogsand three female dogs, carrying out dosing based on a certain dosage, collecting blood samples after dosing, for a blood sample time point, at least collecting two block sampling points before a first peak, at least collecting three blood sampling points near a highest value of each peak, and at least collecting three blood sampling points after a last peak; measuring the blood drug concentrationby using a liquid mass spectrometer; and calculating a fitting constant (DM) for five types of each dog and indicating a minimum value to be a pharmacokinetic standard model class of the dog. According to the invention, the standard model can be established in the dog, the pharmacokinetic parameters of the drug are calculated correctly, and thus a reasonable dosing plan is provided. The method also can be used for calculating and predicting the drug concentration of the drug in the dog, so that a defect of excessive dog dosing amount due to the small pharmacokinetic parameters of the drug formulti-peak phenomenon calculation by the existing pharmacokinetic software is overcome.

Description

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AI Technical Summary

Benefits of technology

This patented technology allows scientists to study how different types of medication work together more accurately than previously possible due to their smaller size compared to other methods like simulators or simulations. By comparing these models against existing data from clinicians we aimed at developing new ways to improve understanding about treatments based on multiple modes such as behavior-based therapy, gene editing, chemotherapies, etc., making them better suited for use by veterinary professionals worldwide.

Problems solved by technology

This patented describes how different types of medicines behave differently when given together. It suggests that there may exist some combinations between them called “multidomics” where they act more like one another than just two things alone. These techniques help predict whether any combination works well on humans without causing harmful reactions even if those same chemical compounds were administered simultaneously.

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