Devices and methods for delivering dry powder medicaments

Abstract

An apparatus includes a first member coupled to a second member. The first member defines a chamber containing a dry powder and includes a chamber wall that forms an outer boundary of the chamber. Thesecond member includes a surface covering the chamber and defines an intake channel and an exit channel. The exit channel is fluidically coupled to the chamber via an exit opening. The intake channelis fluidically coupled to the chamber via an intake port. A center line of the intake channel is tangential to a portion of the chamber wall such that a portion of an inlet airflow conveyed into thechamber via the intake channel has a rotational motion. The intake port is defined at least in part by an intake ramp. The intake ramp includes a transition surface that forms an exit angle with respect to the surface of less than 105 degrees.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Application Serial No. 62 / 477,506, filed March 28, 2017, entitled "Devices and Methods for Delivering Dry Powder Medicaments," the U.S. The provisional application is hereby incorporated by reference in its entirety. technical field [0003] Embodiments described herein relate generally to medical devices and pharmaceutical compositions, and more particularly to pharmaceutical products for the delivery of dry powder medications. Background technique [0004] Pressurized metered dose inhalation devices (pMDIs) are well known for delivering medication to a patient through the patient's lungs. A pMDI consists of a pressurized propellant tank with a metering valve housed in a molded actuator body with an integral mouthpiece. This type of inhalation device presents patients with drug delivery challenges that require considerable force to actuate through inhalation and r...

AI Technical Summary

Problems solved by technology

For example, known dry powder delivery devices are susceptible to performance changes based on any or all of the following: tilting of the device (before or during use), inability to generate sufficient flow and pressure drop (vacuum or negative pressure), user Failure to fully and properly (and in the correct sequence) actuate the mechanism and properly load the cartridge, capsule or blister pack

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