Application of ginkgo terpene lactones to preparation of drugs and health care products for preventing and/or treating tremor
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A ginkgolide, pharmaceutical technology, applied in the field of medicine, can solve problems such as lack of drugs for preventing and/or treating tremor
Active Publication Date: 2019-12-03
CHENGDU BAIYU PHARMA CO LTD
View PDF8 Cites 3 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0005] In order to solve the problem of lack of drugs for preventing and / or treating tremors in the existing medical field, the present invention provides one or more ginkgolide compounds or pharmaceutically acceptable salts, esters, hydrates, solvates, iso Constructs, or their arbitrary crystal forms, racemates, metabolites, or their mixtures as active ingredients in the preparation of medicines and health products for preventing and / or treating tremors
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
[0081] Preparation method: Add 1 part of glycerol monostearate, 1 part of polyethylene glycol, 1 part of carrageenan, 1 part of gum arabic, 1 part of hydroxypropylmethyl cellulose, etc. to the above raw materials, and add to the In the dropping pill machine, heat evenly and stir timely, drop into the immiscible condensate after melting, take out the dropping pill after condensation, wipe off the condensate adhering to the surface, and dry at low temperature.
experiment example 2
[0082] Experimental example 2 ginkgolide lactone dropping pills
[0083] Active ingredient:
[0084] Bilobalide 1000g (1 part) Ginkgolide B 1000g (1 part)
[0085] Preparation method: Add 1 part of glycerol monostearate, 1 part of polyethylene glycol, 1 part of carrageenan, 1 part of gum arabic, 1 part of hydroxypropylmethyl cellulose, etc. to the above raw materials, and add them In the dropping pill machine, heat evenly and stir timely, drop into the immiscible condensate after melting, take out the dropping pill after condensation, wipe off the condensate adhering to the surface, and dry at low temperature.
[0086] Experiment 2 Observing the Effect of Ginkgolide Pills on Patients with Essential Tremor
[0087]1. Diagnostic criteria
[0088] Core diagnostic criteria: A. Obvious and persistent postural and (or) action tremor in hands and forearms; B. No other neurological signs (except gear phenomenon and Froment sign); C. Head tremor only, But not accompanied by dystoni...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention relates to the field of medicine, in particular to application of one or more ginkgo terpene lactone compounds or pharmacologically acceptable salts, esters, hydrates, solvates and isomers of the ginkgo terpene lactone compounds or any crystal forms, racemic mixtures and metabolites of the ginkgo terpene lactone compounds or a mixture of the ginkgo terpene lactone compounds being used as effective components to preparation of drugs and health care products for preventing and / or treating tremor. The problem of the lack of the drugs for preventing and / or treating the tremor in an existing medicine field is solved. The ginkgo terpene lactone compounds and compositions both obviously improve the state of an illness of an essential tremor model mouse, and the improvement action ofa ginkgo terpene lactone B and bilobalide composition and a bilobalide A, bilobalide B and bilobalide C composition on the essential tremor model mouse is close to that of a positive drug propranololhydrochloride. The state of the illness of essential tremor patients and vascular tremor patients is obviously improved, and no adverse reaction is found in clinical observation cases.
Description
technical field [0001] The invention relates to the field of medicine, in particular to the use of ginkgolides in the preparation of medicines and health products for preventing and / or treating tremors. Background technique [0002] Modern studies have shown that the main active ingredients in Ginkgo biloba are flavonoids and ginkgolides. Ginkgo flavonoids include flavonol glycosides, biflavonoids, and catechins. Ginkgolide compounds include Ginkgolide A, Ginkgolide B, Ginkgolide C, Ginkgolide J, Ginkgolide M, Ginkgolide K, Ginkgolide L, Ginkgolide N, and Ginkgolide P , Ginkgolide Q and bilobalide. The research results show that the isolated ginkgolide compounds are similar in structure. The difference between ginkgolide A, ginkgolide B, ginkgolide C and ginkgolide M is the 1, 3, and 7 of the molecular skeleton. Whether the position carbon has a hydroxyl functional group; Ginkgolide L, Ginkgolide K, and Ginkgolide N are obtained by removing a molecule of water from Ginkgo...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more