A photothermal compound based on iridoid amino color reaction and its preparation method and application

A color reaction and iridoid technology, applied in the field of biomedicine, can solve problems such as drug leakage, and achieve the effects of adjustable size, uniform shape and strong repeatability

Active Publication Date: 2021-04-30
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the nano-delivery particles improve and improve the stability and tumor accumulation ability of the photothermal conversion material indocyanine green, it still inevitably involves problems such as drug leakage in the internal circulation.

Method used

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  • A photothermal compound based on iridoid amino color reaction and its preparation method and application
  • A photothermal compound based on iridoid amino color reaction and its preparation method and application
  • A photothermal compound based on iridoid amino color reaction and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] (1) Pre-dissolve phenylalanine dipeptide in hexafluoroisopropanol solution to prepare a solution with a volume concentration of 100 mg / mL; prepare a genipin aqueous solution with a volume concentration of 0.5 mg / mL.

[0057] (2) Add 10 μL of the hexafluoroisopropanol solution of the above-mentioned phenylalanine dipeptide into 1 mL of genipin aqueous solution, mix well by ultrasonic, and react at 70° C. for 24 hours to obtain photothermal particles.

[0058] The physical picture of the photothermal particles obtained in this embodiment is as follows figure 1 As shown in a, the particle size distribution diagram is shown in figure 2 As shown; using phenylalanine dipeptide and genipin cross-linked self-assembly to form photothermal particles, the photothermal particles appear dark blue and have good dispersion.

Embodiment 2

[0060] (1) Dissolve 5 mg of collagen in 2 mL of 0.2 M acetic acid solution, and vortex for 6 hours until the collagen is completely dissolved. A genipin aqueous solution with a volume concentration of 1 mg / mL was prepared.

[0061] (2) Add 500uL of the above-mentioned genipin aqueous solution to the above-mentioned 500uL collagen solution, shake to mix evenly. After standing at 37° C. for 24 hours, a photothermal gel was formed.

[0062] The physical figure of the photothermal gel obtained in this embodiment is as follows figure 1 As shown in b.

Embodiment 3

[0064] (1) Histidine-phenylalanine dipeptide is pre-dissolved in hexafluoroisopropanol solution to prepare a solution with a volume mass concentration of 100 mg / mL; prepare a genipin aqueous solution with a volume mass concentration of 0.5 mg / mL .

[0065] (2) Add 10 μL of the hexafluoroisopropanol solution of the above-mentioned histidine-tryptophan dipeptide into 1 mL of genipin aqueous solution, mix well by ultrasonic, and react at 70° C. for 24 hours to obtain photothermal particles.

[0066] The transmission electron microscope image of the photothermal particles obtained in this example is as follows image 3 shown. Using histidine-phenylalanine dipeptide and genipin cross-linked self-assembly to form a photothermal nanomedicine with good dispersion and an average particle size of 200nm.

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Abstract

The invention relates to a kind of photothermal compound based on the color reaction of iridoid molecule amino group, its preparation method and application. The components of the photothermal compound include iridoid molecules and molecules containing primary amine functional groups; the preparation method of the photothermal compound involved is that the hemiacetal structure of the iridoid molecule and the primary amine functional group undergo nucleophilic Attacking the color reaction, the resulting color products can self-assemble into particles through hydrophobic interactions or form hydrogels through hydrogen bonds; the photothermal compound of this invention has a significant photothermal conversion effect; the photothermal compound of this invention The thermal composite has the advantages of uniform size, good stability, injectability, etc., and the preparation method is simple, mature, and highly reproducible, without adding other photothermal conversion materials; the photothermal composite of the present invention has good biocompatibility, bio It is degradable and has broad application prospects in biomedical fields such as anti-inflammatory and antibacterial, tissue repair and tumor treatment.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a photothermal compound and its preparation method and application. In particular, it relates to a photothermal compound based on the chromogenic reaction of iridoid amino groups, a preparation method thereof and their application in biomedical fields such as anti-inflammatory and antibacterial, tissue repair and tumor treatment. Background technique [0002] Photothermal composites have a wide range of applications in the field of biomedicine, including anti-inflammatory and antibacterial, tissue repair and anti-tumor therapy. Photothermal therapy is characterized by high spatiotemporal selectivity and low systemic damage. Photothermal compounds play an important role in photothermal therapy. After absorbing light of a specific wavelength, the photothermal compound converts light energy into heat energy, and the resulting high temperature has a killing effect on tumor cells...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K45/06A61K49/00A61P31/00A61P31/04A61P35/00
CPCA61K41/0052A61K45/06A61K49/0019A61P31/00A61P31/04A61P35/00A61K2300/00
Inventor 闫学海刘亚美邢蕊蕊邹千里赵鲁阳
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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