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Xylan polysaccharide-iron compound, preparation method and application thereof

A technology of xylan and polysaccharide iron, which is applied in the field of preparation of xylan polysaccharide iron complexes, can solve the problems of toxic side effects and low absorption rate, and achieve the effects of no toxic side effects, good stability, and simple preparation process

Inactive Publication Date: 2019-12-20
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the absorption rate of oral polysaccharide iron complex is very low, and it is easy to produce toxic and side effects at high concentrations.

Method used

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  • Xylan polysaccharide-iron compound, preparation method and application thereof
  • Xylan polysaccharide-iron compound, preparation method and application thereof
  • Xylan polysaccharide-iron compound, preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] The preparation method of the xylan-polysaccharide-iron complex described in this embodiment comprises the following steps:

[0033] (1) Weigh 100mg of xylan, 25mg of trisodium citrate, add 30mL of distilled water to dissolve, place in a constant temperature water bath at 70°C and heat with constant stirring;

[0034] (2) Add 20wt%% NaOH solution dropwise to adjust the pH of the reaction solution to 8, then slowly add 2mol / LFeCl dropwise 3 solution, stirring while dripping;

[0035] (3) repeat above-mentioned operation process, and control the rate of addition of both and the amount of dropping, make the pH of reaction solution remain on 8;

[0036] (4) Stop adding NaOH and FeCl dropwise when reddish-brown insoluble precipitates appear in the reaction solution 3 solution;

[0037] (5) Keep heating in a water bath at 70°C for 1 hour. After stopping the water bath, centrifuge at 4000r / min for 15 minutes while still hot, discard the precipitate, and collect the dark red...

Embodiment 2

[0040] The preparation method of the xylan-polysaccharide-iron complex described in this embodiment comprises the following steps:

[0041] (1) Weigh 75mg of xylan, 25mg of trisodium citrate, add 30mL of distilled water to dissolve, place in a 70°C constant temperature water bath, heat and keep stirring;

[0042] (2) Add 20wt%% NaOH solution dropwise to adjust the pH of the reaction solution to 9, then slowly add 2mol / LFeCl dropwise 3 solution, stirring while dripping;

[0043] (3) repeat above-mentioned operation process, and control the rate of addition of both and the amount of dropping, make the pH of reaction solution remain on 9;

[0044] (4) Stop adding NaOH and FeCl dropwise when reddish-brown insoluble precipitates appear in the reaction solution 3 solution;

[0045] (5) Keep heating in a water bath at 70°C for 1 hour. After stopping the water bath, centrifuge at 4000r / min for 15 minutes while still hot, discard the precipitate, and collect the dark reddish-brown c...

Embodiment 3

[0048] The preparation method of xylan polysaccharide iron complex comprises the steps:

[0049] (1) Weigh 50mg of xylan, 25mg of trisodium citrate, add 30mL of distilled water to dissolve, place in a constant temperature water bath at 80°C and heat with constant stirring;

[0050] (2) Add 20wt%% NaOH solution dropwise to adjust the pH of the reaction solution to 8, then slowly add 2mol / LFeCl dropwise 3 solution, stirring while adding;

[0051] (3) repeat above-mentioned operation process, and control the rate of addition of both and the amount of dropping, make the pH of reaction solution remain on 8;

[0052] (4) Stop adding NaOH and FeCl dropwise when reddish-brown insoluble precipitates appear in the reaction solution 3 solution;

[0053] (5) Keep heating in a water bath at 80°C for 1 hour, stop the water bath, centrifuge at 4000r / min for 15 minutes while it is still hot, discard the precipitate, and collect the dark reddish-brown centrifugate in the upper layer;

[00...

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Abstract

The present invention discloses a xylan polysaccharide-iron compound, a preparation method and an application thereof, and belongs to the field of health-care products. The iron content of the xylan polysaccharide-iron compound is 21%-23%. The method comprises the following steps: dissolving xylan and a complexing agent in distilled water, adjusting pH of a solution to 8-9, heating in a water bathunder an alkaline condition, dropwise adding an aqueous solution of a ferric iron compound while stirring, repeating the process, dropwise adding alkali liquid to enable a reaction system to keep pHto be 8-9, stopping dropwise adding an aqueous solution of the alkali liquid and the ferric iron compound when reddish brown precipitates appear in reaction liquid, continuing heating in the water bath for 1 h, and obtaining the xylan polysaccharide-iron compound after the reaction is finished by dialysis. The prepared iron supplement agent is good in stability, strong in water solubility and freeof toxic and side effects at high concentration, and provides a new direction for research on treatment of iron deficiency anemia.

Description

technical field [0001] The invention relates to the technical field of health care products, in particular to a xylan-polysaccharide-iron complex, a preparation method and an application thereof. Background technique [0002] Iron is one of the essential trace elements for the human body. At present, in clinical practice, ferrous sulfate is used as iron supplement at home and abroad, but this iron supplement method will stimulate the gastrointestinal mucosa, causing nausea, vomiting and diarrhea and other discomfort symptoms. Moreover, the chemical stability is poor, and low-priced iron is prone to generate endogenous free radicals in the body and cause cell membrane damage. Studies have shown that polysaccharides and Fe 3+ Forming polysaccharide-iron complexes through oxygen bridges or hydroxyl bridges, Fe 3+ is reduced to Fe under the action of gastric acid 2+ After that, it can be absorbed and utilized by the body. The complex formed by the complexation of high-valent ...

Claims

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Application Information

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IPC IPC(8): A23L33/165A23L33/125A61K31/715
CPCA23L33/165A23L33/125A61K33/26A61P3/02A61P7/06A61K31/715A23V2002/00
Inventor 李霞孙鹤飞陆凤莹关媛单杨
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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