Inhibitors of kinase networks and uses thereof

A compound and alkynyl technology, applied in the field of kinase network inhibitors and their uses, can solve problems such as toxic hybrid binding

Active Publication Date: 2020-01-07
PURDUE RES FOUND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the challenge with this multipharmacophore is to avoid promiscuous binding that can lead to toxicity

Method used

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  • Inhibitors of kinase networks and uses thereof
  • Inhibitors of kinase networks and uses thereof
  • Inhibitors of kinase networks and uses thereof

Examples

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Embodiment Construction

[0064] While the specification herein illustrates and describes in detail the concepts of the disclosure, the results contained in the specification are to be considered illustrative and not restrictive in nature. It should be understood that only exemplary embodiments have been shown and described, and that all changes and modifications that come within the spirit of the disclosure are desired to be protected.

[0065] The present invention generally relates to compounds that are kinase inhibitors that are useful in the treatment of kinase-mediated diseases, such as inflammation, cancer, viral and bacterial infections, neurological and immune diseases. Pharmaceutical compositions and methods for treating these diseases are within the scope of this invention.

[0066] As used herein, the following terms and phrases shall have the meanings set forth below. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by o...

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Abstract

The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and / or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.

Description

[0001] Cross References to Related Applications [0002] This U.S. patent application relates to and claims the benefit of priority of U.S. Provisional Application Serial No. 62 / 478,069, filed March 29, 2017, and U.S. Provisional Application Serial No. 62 / 616,643, filed January 12, 2018, incorporated by reference Its entire content is incorporated herein. technical field [0003] The present invention relates generally to compounds that are kinase inhibitors and methods of treating diseases mediated by kinases, such as inflammation, cancer, viral and bacterial infections, neurological and immune disorders. Background technique [0004] This section introduces several aspects that may help facilitate a better understanding of the disclosure. Accordingly, these statements should be read in this light and should not be construed as admissions of prior or non-prior art. [0005] Cells contain more than 500 kinases that regulate various processes such as regulation of cell cycl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/395A61K31/435A61K31/47C07D215/00C07D215/06C07D215/38
CPCC07D221/12C07D471/04C07D471/14C07D491/147C07D495/14C07D498/04C07D513/04C07B2200/05C07D209/08C07D231/56C07D401/14C07D413/14C07D417/12C07D519/00
Inventor 赫尔曼·O·辛蒂姆尼图·达亚尔克莱门特·奥波库·特蒙
Owner PURDUE RES FOUND INC
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