Fecal microbiota capsule and preparation method thereof

Abstract

The invention discloses a fecal microbiota capsule which comprises an enteric capsule case and a core material, wherein the core material consists of a core material carrier and fecal microbiota freeze-dried powder; the core material carrier is of a porous round tubular structure; the fecal microbiota freeze-dried powder is adsorbed in pores of the core material carrier; the core material carrieris formed by pressing natural and porous loofah sponge into layers and rolling the layers; and the fecal microbiota freeze-dried powder is prepared from fecal microbiota liquid and freeze-drying protecting agents through freeze-drying. The invention also discloses a preparation method of the fecal microbiota capsule. The preparation method comprises the steps of preparing the fecal microbiota liquid; adding the freeze-drying protection agents into the fecal microbiota liquid; adding the core material carrier; and then performing soaking; and charging the core material into the enteric capsulecase to obtain the fecal microbiota capsule. The fecal microbiota capsule has the advantages that the release speed of the fecal microbiota freeze-dried powder can be reduced; the fecal microbiota inthe fecal microbiota freeze-dried powder is further prevented from being discharged out of the intestinal tract too early; the release duration of the fecal microbiota freeze-dried powder in the intestinal tract is prolonged; the contact with more intestinal walls is realized to increase the fecal microbiota transplantation quantity; and the fecal microbiota transplantation effect is improved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a fecal bacteria capsule and a preparation method thereof. Background technique [0002] The gut microbial ecosystem is the most complex and largest micro-ecosystem in mammals. However, the widespread use of a large number of antibiotics and changes in diet structure have greatly changed the composition of human intestinal microbes, the normal intestinal flora has been damaged, and even Clostridium difficile infection has developed, which has led to some new the occurrence of diseases. "Fecal microbiota transplantation" (FMT) refers to the transplantation of functional flora in the feces of healthy people into the gastrointestinal tract of patients to rebuild new intestinal flora and achieve the treatment of intestinal and extraintestinal diseases. As a key salvage treatment for refractory inflammatory bowel disease (Crohn's disease, ulcerative colitis), fecal microbiota transplantation...

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problem that the core material of the fecal bacteria capsule is released too quickly, and most of the fecal bacteria liquid is discharged, resulting in the unsatisfactory effect of

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