Use of insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 in the management of renal replacement therapy

A renal, therapeutic technology applied in the field of use of insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 in the management of renal replacement therapy, which can address issues such as increased risk

Pending Publication Date: 2020-02-04
机敏医药股份有限公司
View PDF19 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These studies suggest that there is no specific threshold (or time period) for elevated serum creatinine for worsening renal function or AKI, but rather a continuous increase in risk with increasing serum magnitude

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 in the management of renal replacement therapy
  • Use of insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 in the management of renal replacement therapy
  • Use of insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 in the management of renal replacement therapy

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0090] Preparation of solid phase and detectably labeled conjugates typically involves the use of chemical crosslinkers. Crosslinkers contain at least two reactive groups and are generally classified into homofunctional crosslinkers (comprising the same reactive groups) and heterofunctional crosslinkers (comprising different reactive groups). Homobifunctional crosslinkers coupled via amine, sulfhydryl, or nonspecific reactions are available from a number of commercial sources. Maleimides, alkyl and aryl halides, alpha-haloacyl and pyridyl disulfides are thiol reactive groups. Maleimides, alkyl and aryl halides, and α-haloacyls react with sulfhydryls to form thiol ether linkages, while pyridyl disulfides react with sulfhydryls to form mixed disulfides. The pyridyl disulfide product is cleavable. Imino esters are also very useful for protein-protein crosslinking. A variety of heterobifunctional crosslinkers, each combining different properties for successful conjugation, are ...

Embodiment 1

[0162] Example 1. RRT duration is longer in patients with elevated biomarkers.

[0163] ICU patients with acute kidney injury (AKI) receiving renal replacement therapy (RRT) were included in the analysis. Urine samples were collected from each patient during RRT and within 48 hours after initiation of RRT. use on Meter To test the kit, TIMP2, IGFBP7 and TIMP2 x IGBFP7 (the product of the concentrations of the two biomarkers) were measured in urine samples by immunoassay. Patients were divided into two groups based on their biomarker concentrations less than or equal to or greater than specified thresholds. Ranges and medians of RRT days, length of hospital stay, and length of ICU stay were determined for each patient group. Patients with biomarker concentrations greater than the threshold received RRT longer and had longer hospital and ICU stays than patients with biomarker concentrations less than or equal to the threshold.

[0164]

[0165]

Embodiment 2

[0166] Example 2. Selection of RRT modality using biomarkers.

[0167] A 65-year-old man was admitted to the intensive care unit (ICU) after presenting to the emergency department a diagnosis of severe, community-acquired pneumonia. He was intubated and placed on mechanical ventilation due to worsening respiratory insufficiency and inability to maintain adequate oxygenation. He was also found to be hypotensive and received several liters of intravenous (IV) crystalloid IV for volume resuscitation. He was unresponsive, so vasopressor therapy was started to maintain systemic blood pressure. He also underwent pan culture and received broad-spectrum antimicrobial therapy.

[0168] Although he underwent aggressive volume resuscitation and his serum creatinine increased from an admission level of 1.3 mg / dL to 5.1 mg / dL (indicating stage III AKI), his urine output has been consistently below 0.3 mL since admission / kg / hr. He required significant positive pressure ventilatory supp...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Sensitivityaaaaaaaaaa
Sensitivityaaaaaaaaaa
Login to view more

Abstract

The present invention provides methods and compositions for managing renal replacement therapy. A risk score, which is determined from a urinary concentration of IGFBP7 (insulin-like growth factor-binding protein 7) and / or a urinary concentration of TIMP-2 (tissue inhibitor of metalloproteinase 2), is determined obtained from the patient, and is used to manage patient treatment.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 502,728, filed May 7, 2017, the entire contents of which, including all tables, drawings, and claims, are incorporated herein by reference. Background technique [0003] The following discussion of the background of the invention is provided only to assist the reader in understanding the invention and is not to be considered as describing or constituting prior art to the present invention. [0004] The kidneys are responsible for excreting water and solutes from the body. Its functions include maintaining acid-base balance, regulating electrolyte concentrations, controlling blood volume, and regulating blood pressure. Thus, loss of renal function due to injury and / or disease results in substantial morbidity and mortality. A detailed discussion of kidney injury is provided in Harrison's Principles of Internal Medicine, 17th Edition, McGraw Hill, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/47G01N33/493G01N33/68
CPCC07K14/65C07K14/8146C07K14/4702G01N33/493G01N33/6872G01N2333/8146G01N2800/245G01N2800/347G01N2800/52A61K45/06G01N33/543G01N2333/4745
Inventor P·麦克菲森J·P·肯普夫
Owner 机敏医药股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap