Application of dragon blood a in the preparation of drugs for preventing or treating diabetic vascular disease

A technology of dragon blood and diabetes, which is applied in the application field of dragon blood A in the preparation of drugs for the prevention or treatment of diabetic vascular disease, which can solve the problems that the effect has not been reported, and achieve the purpose of inhibiting cell apoptosis, ensuring health, and improving GSH Declining effect of vitality

Active Publication Date: 2021-10-22
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the role of astragalus in the treatment of MGO-induced diabetic vasculopathy has not been reported

Method used

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  • Application of dragon blood a in the preparation of drugs for preventing or treating diabetic vascular disease
  • Application of dragon blood a in the preparation of drugs for preventing or treating diabetic vascular disease
  • Application of dragon blood a in the preparation of drugs for preventing or treating diabetic vascular disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1. Experimental material Culture of human umbilical vein endothelial cells (HUVEC)

[0038] 1.1 Culture conditions

[0039] HUVEC (derived from ATCC) were inoculated in DMEM medium containing 10% (v / v) fetal bovine serum at 37°C, 5% CO 2 in the incubator. Medium was changed every 2 days.

[0040] 1.2 Cell passage

[0041]Take a bottle of HUVEC and observe the cells under an inverted phase-contrast microscope. If they grow into a dense monolayer, they will be passaged. Shake the culture flask gently several times to suspend the fragments floating on the cell surface, then pour out the culture medium together, draw 2mL of phosphate buffered saline solution (PBS, 10mM, pH=7.4) into the culture flask, shake gently Pour away and repeat 2 times. Add 1 mL of trypsin solution containing 0.25% (w / v) EDTA, make it cover the bottom of the bottle, wet the entire cell layer, place it in a 37°C incubator for 2 min, and wait until the cells shrink and become round. Add 2mL of cu...

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PUM

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Abstract

The invention discloses the application of dragon blood A in the preparation of drugs for preventing or treating diabetic vascular disease. The present invention is based on the invention that the inventors of the present invention firstly found that dragon blood A has obvious curative effect on diabetic vascular disease caused by vascular endothelial injury caused by methylglyoxal. Methylglyoxal is a highly active glucose-toxic metabolite, which is greatly increased in diabetic patients, especially in patients with diabetic complications. The curative effect of dragon blood element A on diabetic vascular disease caused by endothelial injury caused by methylglyoxal is embodied in improving cell morphology, increasing cell survival rate, reducing cell apoptosis rate, alleviating cell oxidative stress damage, clearing methylglyoxal and reducing sugar residues. Chemical end product content and so on.

Description

technical field [0001] The present invention relates to the application of dragon blood A, in particular to the application of dragon blood A in the preparation of drugs for preventing or treating diabetic vascular disease. Background technique [0002] According to authoritative statistics, as of 2017, the number of diabetic patients in my country has reached 114 million, while globally, according to the latest statistics from the International Diabetes Federation (IDF), the number is about 425 million, and the total number of patients is expected to reach 2040. will rise to 700 million. According to the latest data from Lancet, the number of adults with diabetes worldwide has more than tripled in the 30 years from 1980 to 2014. Diabetes mellitus is a lifelong metabolic disease characterized by chronic hyperglycemia. Long-term high blood sugar in the patient's body can lead to damage to multiple organs throughout the body. According to statistics, every 6 seconds in the wo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61P3/10A61P9/10A61P9/00
CPCA61K31/12A61P3/10A61P9/00A61P9/10
Inventor 聂红汤丹肖伟饶娇雨朱涛
Owner JINAN UNIVERSITY
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