5results about How to "Reduce ROS levels" patented technology

This invention relates to the field of cosmetics, specifically to a composition containing copper peptides for repairing photothermal damage and its application. The composition comprises a complex polypeptide, galactosomal yeast fermentation product filtrate, and cyanobacterial extract; wherein the complex polypeptide includes copper peptides, yeast polypeptides, and hexapeptide-11. This invention, by combining specific complex polypeptides with galactosomal yeast fermentation product filtrate and cyanobacterial extract, increases the expression level of heat shock proteins, thereby achieving excellent efficacy in repairing photothermal damage. Furthermore, this composition is mild and non-irritating, and can be widely used in cosmetics.

The present application provides a bisborate compound with ROS scavenging activity and cell protection effect, a pharmaceutically acceptable salt, ester, solvate, crystal form or prodrug thereof, a pharmaceutical composition containing the same and uses thereof, and provides an in vitro cell model of an oxidative stress model and a method for screening ROS scavengers using the same. The platform provided by the present application for efficiently screening ROS scavengers has the characteristics of simple operation and good reproducibility, and can be used for drug screening and development of oxidative stress related diseases.

This invention discloses an MFN1-engineered mitochondrial vesicle and its application in the preparation of anti-cellular aging drugs. The MFN1-engineered mitochondrial vesicle is first constructed by... MFN1 Gene overexpression vectors are used to transfect cells and obtain overexpression. MFN1 Cell lines containing the gene were cultured, culture medium was collected, and mitochondrial vesicles were isolated and extracted to obtain MFN1-MDVs, engineered mitochondrial vesicles rich in mtDNA. MFN1-MDVs were used to treat senescent cells caused by mitochondrial dysfunction. Results showed that MFN1-MDVs could be internalized into senescent cells, effectively increasing mitochondrial mtDNA and ATP content, enhancing oxidative phosphorylation levels, increasing antioxidant enzyme activity and reducing ROS, restoring mitochondrial membrane potential, and ultimately improving mitochondrial network structure, demonstrating significant potential for mitochondrial function repair and improvement of cell senescence.

This invention discloses a Chlamydomonas reinhardtii synergistic exosome hydrogel microneedle, its preparation method, and its application, belonging to the field of biomedical materials and microneedle delivery technology. The hydrogel microneedles prepared in this invention use methacryloxymethyl carboxymethyl chitosan and methacryloxyhyaluronic acid as the hydrogel matrix. After adding a photoinitiator to the hydrogel matrix, the microneedles are obtained through molding and ultraviolet crosslinking. The tips of the hydrogel microneedles are loaded with Chlamydomonas reinhardtii exosomes to improve transdermal delivery efficiency. The backing layer or matrix portion of the hydrogel microneedles is loaded with Chlamydomonas reinhardtii to maintain its photosynthetic activity and provide continuous local oxygen supply. This invention constructs a multifunctional therapeutic system for the synergistic effect of Chlamydomonas reinhardtii and exosomes. This system integrates in-situ photosynthetic oxygen supply, exosome anti-inflammatory repair, and local microneedle delivery onto the same platform, and can simultaneously intervene in key aspects of osteoarthritis such as hypoxia, inflammation, and insufficient tissue repair, showing promising application prospects.

The application discloses a kind of genes RhNADP-LIKE for regulating the aging of Chinese rose flower, and specifically relates to the technical field of molecular biology and horticultural plant physiology.The application filters the bottle insertion life phenotype data of 358 tetraploid Chinese rose core germplasm by whole genome association analysis (GWAS), and identifies the gene RhNADP-LIKE significantly associated with aging.The gene accelerates the petal aging process by regulating the accumulation of reactive oxygen species (ROS).After inhibiting the expression of RhNADP-LIKE using virus-induced gene silencing (VIGS) technology, the opening period of Chinese rose flower is extended by about 2 days, and the ROS level is significantly reduced.The application provides a molecular target for extending the bottle insertion life of Chinese rose, which can be applied to gene editing breeding or the development of environmentally friendly preservatives, reducing the dependence on chemical agents, and improving the economic benefits and sustainable development potential of cut flower industry.