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36results about How to "Reduce ROS levels" patented technology
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Application of prussian blue nanoparticles in preparation of drugs for preventing, delaying or treating nervous system degenerative diseases
ActiveCN111529547AEasy to makeEasy mass productionPowder deliveryHeavy metal active ingredientsNervous systemNerve cells
The invention relates to an application of prussian blue nanoparticles in preparation of drugs for preventing, delaying or treating nervous system degenerative diseases. Researches find that the prussian blue nanoparticles have remarkable effects in the aspects of preventing, delaying or treating nervous system degenerative diseases. Cell level test results show that the prussian blue nanoparticles can reduce the ROS level in nerve cells stimulated by hydrogen peroxide and increase the proportion of living cells in the nerve cells stimulated by hydrogen peroxide; and animal level test resultsshow that the prussian blue nanoparticles can significantly reduce the expression level of oxidative stress markers in hippocampus of nervous system degenerative disease model mice, significantly improve the learning and memory ability of nervous system degenerative disease model mice, and improve dyskinesia. The preparation process of the prussian blue nanoparticles is simple, the macro production is easy, the reaction condition is mild, and the surface modification is easy.
Owner:TIANJIN UNIV
Applications of compound SS-31 in preparing drugs or preparations used for treating atherosclerosis and related diseases
InactiveCN107041946AReduce formationReduce ROS levelsTetrapeptide ingredientsCardiovascular disorderCoronary heart diseaseAtheroma
The invention provides drugs used for treating atherosclerotic diseases such as carotid artery stenosis, lower extremity atherosclerotic occlusive disease, and coronary heart disease, and more specifically discloses applications of compound Szeto-Schiller-31 (SS-31) in preparing drugs or preparations used for treating atherosclerosis and related diseases, and belongs to the field of medicine, and more specifically belongs to the field of novel pharmaceutical applications of compounds. It is found via experiments that SS-31 is capable of reducing atherosclerosis degree, reducing mouse arterial ROS level obviously, reducing oxidative damage, increasing ATP level, reducing the content of macrophages at atherosclerotic plaques obviously, increasing the content of smooth muscle cells and the content of collagen at atherosclerotic plaques obviously, stabilizing atherosclerotic plaques, improving inflammation level obviously, and reducing expression of lipid intake protein at atherosclerotic plaques; and it is shown by results that SS-31 is capable of treating atherosclerosis and related diseases.
Owner:NANJING UNIV
Method for improving acid stress resistance of candida glabrata
ActiveCN104789600AImprove growth performanceImprove acid stress resistanceFungiStable introduction of DNAAcetic acidCandida glabrata
The invention discloses a method for improving the acid stress resistance of candida glabrata, and belongs to the field of bioengineering. The method comprises the following steps: improving the candida glabrata, constructing a gene-deleted mutant strain Cgade12Delta, measuring the intracellular ATP level of the constructed strain, and determining the organic acid tolerance of the strain by a plate growth experiment and cellular activity analysis. After the deletion of the gene CgADE12 is found out, the intracellular ATP level of the strain under the stress of 0.2 percent acetic acid is lowered, the growth capability under the stress of acetic acid is improved, and the acetic acid tolerance is improved.
Owner:JIANGNAN UNIV
Bifidobacterium breve NX-5 and application thereof in oxidation resistance
InactiveCN113151072AReduce ROS levelsIncrease SOD activityMilk preparationCosmetic preparationsBiotechnologyDismutase
The invention discloses bifidobacterium breve NX-5 and application thereof in oxidation resistance, and belongs to the technical field of microorganisms. The preservation number of the bifidobacterium breve NX-5 disclosed by the invention is CGMCC (China General Microbiological Culture Collection Center) No.20113; and fermentation supernate and bacterial suspension of the bifidobacterium breve NX-5 can remarkably reduce the level of reactive oxygen species in a zebra fish body and remarkably improve the activity of superoxide dismutase in the zebra fish body in an in-vivo oxidative stress model, and have the potential of being applied to in-vivo oxidation resistance. The bifidobacterium breve NX-5 disclosed by the invention has a huge potential application prospect in the aspect of oxidation resistance.
Owner:广东南芯医疗科技有限公司 +2
Application of phospholipid polyethylene glycol modified subminiature cerium oxide nano-enzyme in preparation of medicine for treating acute kidney injury
InactiveCN112274634AHigh biosecurityExtend systemic circulation timePeptide/protein ingredientsInorganic active ingredientsPolythylene glycolApoptosis
The invention discloses application of a phospholipid polyethylene glycol modified subminiature cerium oxide nano-enzyme in preparation of a medicine for treating acute kidney injury. The acute kidneyinjury is induced by cis-platinum when cis-platinum is used for treating solid cancer. The phospholipid polyethylene glycol modified subminiature cerium oxide nano-enzyme provided by the invention can present activities of various antioxidant mimic enzymes, can play an efficient catalase activity in a physiological environment, effectively reduces the ROS level by acting on an Nrf2 / Keap1 pathway,inhibits cell apoptosis, exerts important protection and treatment effects on acute kidney injury caused by cis-platinum, and is a more promising nanomaterial for low-toxicity anti-tumor applicationand development cis-platinum in clinical practice.
Owner:ZHEJIANG UNIV
Lactobacillus rhamnosus E2 for producing hyaluronic acid and application of lactobacillus rhamnosus E2
ActiveCN114790430AReduce ROS levelsIncrease SOD activityCosmetic preparationsMilk preparationBiotechnologyDismutase
The invention discloses lactobacillus rhamnosus E2 for producing hyaluronic acid and application of the lactobacillus rhamnosus E2, and belongs to the technical field of microorganisms. The preservation number of the lactobacillus rhamnosus E2 for producing hyaluronic acid disclosed by the invention is CGMCC (China General Microbiological Culture Collection Center) No.21770, and the lactobacillus rhamnosus E2 can produce hyaluronic acid under a fermentation condition. The fermentation supernatant and bacterial suspension of the lactobacillus rhamnosus E2 disclosed by the invention can significantly reduce the level of reactive oxygen in the zebra fish body and significantly improve the activity of superoxide dismutase in the zebra fish body in an in-vivo oxidative stress model, and have the potential of being applied to in-vivo oxidation resistance and senescence delaying; in addition, in a zebra fish injury model, zebra fish tail fin injury repair can be remarkably promoted, and the good potential for promoting tissue injury repair is shown. The lactobacillus rhamnosus E2 disclosed by the invention has a huge potential application prospect in the aspects of resisting oxidation, delaying senescence and promoting tissue damage repair.
Owner:FOSHAN LANGSEE BIOTECHNOLOGY CO LTD +1
Application of Pinctada martensii mucus in extraction of exosome, exosome as well as extraction method and application of exosome
PendingCN114480249AImprove use valueIncrease vitalityCell dissociation methodsAntipyreticInflammatory factorsBiophysics
The invention provides application of pinctada martensii mucus to extraction of exosomes, the exosomes and an extraction method and application of the exosomes. According to the method, the vesicular nanoparticles are separated from the pinctada martensii mucus by adopting an ultracentrifugation method and are identified as the exosome, so that reference is provided for extracting the bioactive exosome from marine organisms, and meanwhile, the utilization value of the pinctada martensii is also improved. The exosome extracted from the pinctada martensii mucus can enhance the cell viability, reduce the ROS level in cells, inhibit the activation of NF-kappa B and NLRP3 pathways and reduce the expression level of related inflammatory factors mRNA, and has a certain anti-inflammatory effect.
Owner:GUANGDONG OCEAN UNIVERSITY +1
Application of rotenone in preparing medicine for treating diabetic nephropathy
InactiveCN108524492AImprove polyuria symptomsReversible glomerular hypertrophyOrganic active ingredientsMetabolism disorderDrugToxicity
The invention aims to provide application of rotenone in preparing a medicine for treating diabetic nephropathy to provide a novel candidate compound for treating diabetic nephropathy. Experimental results show that rotenone of a selected dosage has no liver, kidney and heart toxicity; hyperuresis of diabetic nephropathy model mice can be remarkably alleviated, and kidney weight increase, glomerular hypertrophy, impaired renal function, microalbuminuria increase, kidney metabolic disorders and renal fibrosis, caused by STZ, of the mice are reversed.
Owner:NANJING CHILDRENS HOSPITAL
Roxburgh rose pomace combined phenol with remarkable antioxidant activity as well as preparation method and application thereof
ActiveCN114081178ARich in compositionSynergistic antioxidant activityFood ingredient as antioxidantFood preservationFreeze-dryingEthyl acetate
The invention discloses roxburgh rose pomace combined phenol with remarkable antioxidant activity as well as a preparation method and application of the roxburgh rose pomace combined phenol. The method comprises the following steps: mixing roxburgh rose pomace dry powder with n-hexane, shaking, centrifuging, collecting residues, and drying to obtain degreased roxburgh rose pomace dry powder; mixing the degreased roxburgh rose pomace dry powder with ethanol, and extracting at normal temperature; mixing the obtained residues with a 2-4mol / L NaOH solution, introducing protective gas, sealing, extracting at room temperature for 1-2 hours, adjusting the pH value of the solution to 2-4 by using HCl to obtain a mixed solution, extracting by using ethyl acetate, centrifuging, collecting the ethyl acetate phase, concentrating under reduced pressure, and freeze-drying to obtain the roxburgh rose pomace combined phenol extract. The roxburgh rose pomace combined phenol extract prepared by the invention is high in purity and rich in phenolic substances, has relatively high DPPH and ABTS free radical scavenging ability and oxygen free radical absorption ability, and can also be used in healthy foods or medicines for adjuvant therapy of oxidative stress related diseases.
Owner:SOUTH CHINA UNIV OF TECH
Preparation method for pollen pini-radix curcuma antioxidant skin care product
ActiveCN109984963AGood flexibilityReduce ROS levelsCosmetic preparationsToilet preparationsMedicineSkin elasticity
The invention discloses a preparation method for a pollen pini-radix curcuma antioxidant skin care product. The preparation method comprises the steps of preparation of pollen pini extracts and radixcurcuma extracts, and mixing of the extracts to prepare the antioxidant skin care product. The preparation method has the advantages that the antioxidant skin care product prepared by using the natural extracts from pollen pini and radix curcuma contains no harmful chemical additives, and the antioxidant skin care product can effectively scavenge free radicals, reduce the ROS level, improve the antioxidant enzyme activities, improve the skin elasticity and delay senescence.
Owner:烟台新时代健康产业日化有限公司
Application of hederagenin derivative in preparation of medicine for resisting myocardial hypoxia-reoxygenation injury
ActiveCN111333694AImprove solubilityGood physical and chemical propertiesSteroidsCardiovascular disorderHypoxia reoxygenationMyocardial hypoxia
The invention relates to the technical field of medicines, in particular to application of a hederagenin derivative in preparation of a hypoxia-reoxygenation injury medicine for myocardial ischemia and reperfusion injury prevention. The compound is stable in a solution; the compound has obvious protective activity against myocardial hypoxia-reoxygenation injury, especially the hypoxia-reoxygenation injury of myocardial ischemia and reperfusion injuries; the myocardium can be well protected from hypoxia-reoxygenation injury when the concentration is 80 micromole / L, and the derivative has stronger pharmacological activity than the parent nucleus hederagenin under the same dosage, so that a new choice is provided for protection against myocardial hypoxia-reoxygenation injury and myocardial ischemia-reperfusion injury.
Owner:JILIN ACAD OF TRADITIONAL CHINESE MEDICINE
Pharmaceutical composition for treating ovarian cancer and related preparation thereof
ActiveCN108938610AHigh activityPrevent proliferationOrganic active ingredientsAntineoplastic agentsOvarian cancerThymoquinone
Owner:AFFILIATED HOSPITAL OF JIANGSU UNIV
Exogenous mitochondrial vector and compound and preparation method and application of exogenous mitochondrial vector and compound
PendingCN112999357ALow toxicityImprove intake efficiencySenses disorderNervous disorderDiseaseDrug compound
The invention discloses an exogenous mitochondrial vector and a compound as well as a preparation method and application of the exogenous mitochondrial vector and the compound; in-vitro exogenous mitochondria is modified by one or more materials with good biocompatibility, a functional gene and / or drug is encapsulated by the modified in-vitro exogenous mitochondria, finally, the two components are jointly delivered to diseased cells to treat mitochondrial defect related diseases. A delivery system is composed of the in-vitro exogenous mitochondria with intact functions, a material with good biocompatibility and the functional gene / drug. Mitochondria mito extracted from autologous or allogenic tissues and cells is subjected to special treatment with the materials with good biocompatibility to form coating-mito, then the coating-mito is mixed and incubated with the functional gene and / or drug according to a certain proportion, and the exogenous mitochondria drug compound is formed through non-covalent acting force. The exogenous mitochondria drug compound can be efficiently taken by damaged cells, and can release normal mitochondria and the related functional gene and / or drug in cytoplasm.
Owner:CHINA PHARM UNIV
Application of loureirin A to preparation of medicine for preventing or treating diabetic angiopathy
ActiveCN110755416AHas the ability to clear MGOSignificant effectMetabolism disorderKetone active ingredientsMetaboliteVascular endothelium
The invention discloses application of loureirin A to preparation of medicine for preventing or treating diabetic angiopathy. The application of the loureirin A to the preparation of the medicine forpreventing or treating the diabetic angiopathy is provided based on the fact that the inventor finds for the first time that the loureirin A has an obvious curative effect on the diabetic angiopathy caused by vascular endothelial injury caused by methylglyoxal. The methylglyoxal is a highly active glucose toxic metabolite, and is greatly increased in patients with diabetes, especially in patientswith complications of the diabetes. The curative effect of the loureirin A on the diabetic angiopathy caused by the vascular endothelial injury caused by the methylglyoxal is specifically reflected inimproving cell morphology, increasing the cell survival rate, reducing the apoptosis rate, alleviating cell oxidative stress injury, removing the methylglyoxal and reducing the content of advanced glycosylation end products and the like.
Owner:JINAN UNIVERSITY
A preparation g-c 3 no 4 Method of composite carrier with carbon fiber
ActiveCN109126896BAvoid uneven mixingControllable adjustment of adhesionCatalyst carriersElectrospinningCarbonization
a preparation g -C 3 N 4 In the method of composite carrier with carbon fiber, a certain amount of nitrogen-containing organic matter is added to the organic reagent, after mixing evenly, electrospinning is carried out, and the product is pre-oxidized and carbonized, and then the product is oxidized to obtain g -C 3 N 4 and carbon fiber composite carrier. Preparation of the present invention g -C 3 N 4 Composite carrier with carbon fiber has the characteristics of simple preparation process, adjustable specific surface area, pore size and surface polarity of the carrier. When applied to immobilized cell fermentation, it has high immobilization efficiency and fermentation stability.
Owner:HENAN UNIVERSITY OF TECHNOLOGY
Active ingredients, extraction method and application in the preparation of neuroprotective drugs
ActiveCN110204589BStable structureReduce pollutionNervous disorderSugar derivativesNeuroprotective DrugsTriterpenoid saponin
The present invention relates to the active ingredient of A. chinensis, which is characterized in that it comprises oleanolic acid-type triterpenoid saponins and / or phenylacetonitrile glycosides, and the structural formula of the oleanolic acid-type triterpenoid saponins is as follows: The structural formula of phenylacetonitrile glycosides is shown below: . The present invention also provides a preparation method of the active ingredient of the Fructus Arugulae. According to the experiment, the invention finds that the active components of Fructus chinensis have a good protective effect on the oxidative damage of nerve cells NSC34, and can be used for preparing neuroprotective drugs or health care products.
Owner:HENAN UNIVERSITY
ROS responsive bionic nanoparticles for improving oxidation microenvironment and preparation method thereof
ActiveCN112675145AEasy to prepareLow costMetabolism disorderAntipyreticInflammatory factorsFreeze-drying
The invention discloses ROS responsive bionic nanoparticles for improving an oxidation microenvironment and a preparation method thereof. The preparation method comprises the steps of immersing cells in a hypotonic solution, centrifuging, ultrasonically treating and freeze-drying to obtain a nanoscale cell membrane; preparing a medicine into a solution I, preparing an ROS responsive polymer material into a solution II, and dropwise adding the solution I into the solution II while carrying out ultrasonic treatment to obtain a mixed solution; adding an emulsifier aqueous solution and the nanoscale cell membrane into a container, and ultrasonically dropping into the mixed solution; and volatilizing the solvent, centrifuging, washing with water, and freeze-drying to obtain the product. The method is simple and low in cost. The ROS response sensitivity is high, the ROS level is reduced, inflammatory response is inhibited, and therefore the pathological microenvironment is improved. The nanoparticles can be more phagocytized by macrophages, excessive ROS and inflammatory factor expression in the cells are reduced, and the bioavailability is high. Animal experiments prove that the nanoparticles have a better disease treatment effect than free drugs, and show a synergistic effect.
Owner:INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
A kind of tripeptide and its preparation method and application
ActiveCN109369778BReduce ROS levelsAnti-aging effectAntinoxious agentsTripeptide ingredientsIntracellularEfficacy
The invention relates to the technical field of polypeptides, in particular to tripeptide and a preparation method and use thereof. The tripeptide FGF has the amino acid sequence of Phe-Gln-Phe, and the preparation method and the use of the tripeptide are provided. Experiments show that FITC fluorescence intensity of FQF high and low dose groups has significant difference, indicating that FQF cansignificantly reduce the intracellular ROS level and play an antioxidant role. The tripeptide can be widely used in the preparation of drugs or foods inhibiting CD38 enzyme activity, or in the preparation of drugs or foods with anti-oxidation and anti-aging effects.
Owner:INFINITUS (CHINA) CO LTD
Application of dragon blood a in the preparation of drugs for preventing or treating diabetic vascular disease
ActiveCN110755416BHas the ability to clear MGOSignificant effectMetabolism disorderKetone active ingredientsMetaboliteVascular endothelium
The invention discloses the application of dragon blood A in the preparation of drugs for preventing or treating diabetic vascular disease. The present invention is based on the invention that the inventors of the present invention firstly found that dragon blood A has obvious curative effect on diabetic vascular disease caused by vascular endothelial injury caused by methylglyoxal. Methylglyoxal is a highly active glucose-toxic metabolite, which is greatly increased in diabetic patients, especially in patients with diabetic complications. The curative effect of dragon blood element A on diabetic vascular disease caused by endothelial injury caused by methylglyoxal is embodied in improving cell morphology, increasing cell survival rate, reducing cell apoptosis rate, alleviating cell oxidative stress damage, clearing methylglyoxal and reducing sugar residues. Chemical end product content and so on.
Owner:JINAN UNIVERSITY
Application of AKT2 inhibitor in preparation of medicine for treating non-alcoholic fatty liver disease
ActiveCN113509555ADefinite curative effectGood effectOrganic active ingredientsMetabolism disorderSide effectCytoplasm
The invention discloses an application of an AKT2 inhibitor in the preparation of a medicine for treating a non-alcoholic fatty liver disease, and belongs to the technical field of biological medicines. Pharmacological experiment results prove that the AKT2 inhibitor (CCT128930) has a good treatment effect on an L02 cell lipid deposition model induced by free fatty acid for the first time, lipid deposition in cells and ROS level in cytoplasm are reduced, and Caspase 3 enzyme activity can be reduced, so that cell apoptosis caused by free fatty acid is reduced. The AKT2 inhibitor is used for preparing the medicine for treating the non-alcoholic fatty liver disease, the curative effect is definite, the effect is obvious, the side effect is low, and the medical application prospect is wide.
Owner:CHINA PHARM UNIV
A method for improving acid stress tolerance of Torulopsis glabrata
ActiveCN104789600BImprove growth performanceImprove acid stress resistanceFungiStable introduction of DNATorulopsis glabrataBio engineering
The invention discloses a method for improving the acid stress resistance of T. glabrata, belonging to the field of biological engineering. The present invention constructs a gene deletion mutant strain Cgade12Δ by transforming T. glabrata, measures the intracellular ATP level of the constructed strain, and analyzes the organic acid tolerance of the strain through a plate growth experiment and cell activity. After the deletion of the gene CgADE12 was found, under 0.2% acetic acid stress, the intracellular ATP level of the strain decreased, the growth ability under acetic acid stress increased, and the acetic acid tolerance was enhanced.
Owner:JIANGNAN UNIV
Biotin labeled ligustrazine and preparation method thereof
InactiveCN103936758APowerful Targeted MonitoringGood treatment effectOrganic active ingredientsOrganic chemistryBiotin-streptavidin complexApoptosis
The invention belongs to the biotechnical field, and concretely relates to a mitochondrial TFAM target conjugate and its application in mitochondrial function stabilization maintenance. A biotin labeled ligustrazine molecule is designed in the invention, and the affinity between streptavidin and biotin is high, so a stable labeled probe-ligustrazine compound plays a role in clinic monitoring and treatment. The TFAM targeting conjugate can be specifically bound with TFAM to protect the TFAM from being degraded by Lon protease, and the mitochondrial stabilization is maintained by reducing the level of ROS in cells and reducing cell apoptosis.
Owner:WENZHOU MEDICAL UNIV
Protective effect of biochanin A on hippocampal neuron cells
InactiveCN110227074AAvoid damagePromote proliferationOrganic active ingredientsNervous disorderHydrogenDose dependence
The invention discloses a protective effect of biochanin A on hippocampal neuron cells. The effect of the biochanin A on the injury of primary hippocampal neurons in rats induced by hydrogen peroxideincludes: Bio A preconditioning group can significantly inhibit the injury of hippocampal neurons induced by H2O2; Bio A treatment group can obviously reduce the ROS level in cells; and after Bio A treatment, the invention can up-regulate Bcl-2 protein expression of model cells, and down-regulate Bax and Casepase-3 protein expression dose-dependently.
Owner:TAISHAN MEDICAL UNIV
Tripeptide and preparation method and use thereof
The invention relates to the technical field of polypeptides, in particular to tripeptide and a preparation method and use thereof. The tripeptide FGF has the amino acid sequence of Phe-Gln-Phe, and the preparation method and the use of the tripeptide are provided. Experiments show that FITC fluorescence intensity of FQF high and low dose groups has significant difference, indicating that FQF cansignificantly reduce the intracellular ROS level and play an antioxidant role. The tripeptide can be widely used in the preparation of drugs or foods inhibiting CD38 enzyme activity, or in the preparation of drugs or foods with anti-oxidation and anti-aging effects.
Owner:INFINITUS (CHINA) CO LTD
A kind of substituted phenyl indoline carbazole derivative and its preparation method and application
InactiveCN105218552BThe synthesis method is simpleReduce ROS levelsOrganic active ingredientsOrganic chemistryStructural formulaPerylene derivatives
The invention discloses a substituted phenyl indoline carbazole derivative and a preparation method and application thereof. Please see the structural formula in formula I, wherein Ar adopts hydroxyphenyl or 3-carboxyl-4-hydroxyphenyl or 3,5-dimethoxy-4-hydroxyphenyl. The substituted phenyl indoline carbazole derivative can obviously lower the ROS level in a leukemia cell and can serve as a candidate compound of an antineoplastic drug and / or an anti-leukemia chemotherapeutic agent and / or a leukemia differentiation inducer.
Owner:FIELD OPERATION BLOOD TRANSFUSION INST OF PLA SCI ACAD OF MILITARY
Application of Prussian blue nanoparticles in the preparation of drugs for preventing, delaying or treating neurodegenerative diseases
ActiveCN111529547BEasy to makeEase of mass productionPowder deliveryHeavy metal active ingredientsNervous systemNerve cells
Owner:TIANJIN UNIV
Tea beverage containing probiotics and preparation method and application thereof
InactiveCN113367212AIncrease SOD activityInhibition of secretionPre-extraction tea treatmentBiotechnologyLactobacillus rhamnosus
The invention discloses a tea beverage containing probiotics and a preparation method and application thereof, and belongs to the technical field of beverage production. The invention discloses a tea beverage containing the probiotics. The tea beverage is prepared from the following raw materials of lactobacillus rhamnosus NX-2, lactobacillus plantarum NX-1, lactobacillus casei LS01, bifidobacterium animalis NX-6, lactobacillus acidophilus LA-03, a tea bag, soft white sugar, psyllium seed husk and fructo-oligosaccharide. The tea beverage can significantly reduce the ROS level in the zebra fish body and significantly improve the SOD activity in the zebra fish body in an in-vivo oxidative stress model, and shows good anti-oxidation and anti-aging effects; and in addition, secretion of MMP-2 and MMP-9 can be remarkably inhibited in an HSF photoaging model, and a good probiotic effect of delaying skin aging is shown.
Owner:FOSHAN LANGSEE BIOTECHNOLOGY CO LTD +2
Application of neomangiferin in vascular endothelial cell protection
InactiveCN107397754AIncrease total SOD activityAvoid Oxidative DamageOrganic active ingredientsSenses disorderVascular endotheliumBlood vessel
The invention discloses application of neomangiferin in vascular endothelial cell protection. The neomangiferin can reduce the ROS level in vascular endothelial cells and enhance the total SOD activity in the vascular endothelial cells; oxidative damage of the cells is inhibited effectively, and then a new acting pathway and the therapeutic mechanism of the neomangiferin on treatment of cardiovascular diseases and diabetic vascular complications are clear; and bases are provided for the clinical medicine of the neomangiferin.
Owner:TONGHUA HUAXIA PHARMA +1
Saccharomyces cerevisiae engineering strain for high yield of protopanaxadiol and construction method and use
InactiveCN110616231AIncrease productionReduce ROS levelsFungiMicroorganism based processesProtopanaxadiolGene expression
The invention discloses a saccharomyces cerevisiae engineering strain for high yield of protopanaxadiol and a construction method and use. The construction method of the saccharomyces cerevisiae engineering strain for high yield of protopanaxadiol comprises the following steps: constructing a Pgk1p-YBP1-Cyc1t gene expression cassette, and performing introduction into a ura3 site of a saccharomycescerevisiae engineering strain to obtain the saccharomyces cerevisiae engineering strain W3a-Py for high yield of protopanaxadiol. The experimental results show that the saccharomyces cerevisiae engineering strain for high yield of protopanaxadiol can reduce an intracellular ROS level of the strain by 62.3% (84 h of fermentation), and the yield of protopanaxadiol in a shake flask is increased from1.40 g / L to 1.67 g / L.
Owner:TIANJIN UNIV
Application of Citrus chachiensis seed polymethoxylated flavonoid compound in preparation of antioxidant
PendingCN114146124AProtectiveReduce ROS levelsCosmetic preparationsOrganic active ingredientsDietary supplementNeuro-degenerative disease
The invention belongs to the technical field of plant effective component extraction and application, and discloses application of Citrus chachiensis seed polymethoxylated flavonoid compounds in preparation of antioxidants. The Citrus chachiensis embryo polymethoxylated flavone extract has a protection effect on oxidative damage of cells, can significantly reduce the ROS level in the cells and recover the membrane potential of mitochondria so as to recover the functions of the mitochondria, further reduces oxidative stress damage, shows a good clinical anti-oxidation effect, and has good clinical application prospects. The compound can be applied to various medicines, foods and skin care products with higher requirements on safety, and the oxidation resistance of corresponding products is improved; or independently as an antioxidant; the beverage can also be used as a dietary supplement for removing redundant free radicals in the body and preventing or delaying senescence; or the compound can be used as a medicine or an auxiliary medicine for treating diseases such as neurodegenerative diseases, tumors or inflammations related to oxidative damage.
Owner:SUN YAT SEN UNIV +1
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