Protective effect of biochanin A on hippocampal neuron cells

Abstract

The invention discloses a protective effect of biochanin A on hippocampal neuron cells. The effect of the biochanin A on the injury of primary hippocampal neurons in rats induced by hydrogen peroxideincludes: Bio A preconditioning group can significantly inhibit the injury of hippocampal neurons induced by H2O2; Bio A treatment group can obviously reduce the ROS level in cells; and after Bio A treatment, the invention can up-regulate Bcl-2 protein expression of model cells, and down-regulate Bax and Casepase-3 protein expression dose-dependently.

Description

technical field

[0001] The invention belongs to the field of biotechnology, and relates to the protective effect of biochanin A on hippocampal neuron cells. Background technique

[0002] Alzheimer's disease (AD), commonly known as senile dementia, belongs to the categories of "dementia", "dementia" and "dementia" in traditional Chinese medicine, and is one of the most common types of senile dementia. Epidemiological and clinical experimental studies at home and abroad have shown that with the decline of estrogen levels in middle-aged and elderly women after menopause, their risk and rate of AD will also increase greatly, and the degree of cognitive impairment in AD patients is significantly higher than that in elderly patients. male. For example, giving estrogen replacement therapy (hormone replacement therapy, HRT) to perimenopausal women (especially women after oophorectomy) can greatly reduce the risk of AD and improve the cognitive function of AD patients. Nevertheless...