Bifidobacterium breve NX-5 and application thereof in oxidation resistance

A technology of Bifidobacterium breve and NX-5, applied in the field of microorganisms, can solve the problems of not being suitable, few probiotics, and dependence on imports of probiotics, so as to reduce the level of ROS and improve the activity of SOD.
CN113151072AInactive Publication Date: 2021-07-23广东南芯医疗科技有限公司 +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
广东南芯医疗科技有限公司
Publication Date
2021-07-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses bifidobacterium breve NX-5 and application thereof in oxidation resistance, and belongs to the technical field of microorganisms. The preservation number of the bifidobacterium breve NX-5 disclosed by the invention is CGMCC (China General Microbiological Culture Collection Center) No.20113; and fermentation supernate and bacterial suspension of the bifidobacterium breve NX-5 can remarkably reduce the level of reactive oxygen species in a zebra fish body and remarkably improve the activity of superoxide dismutase in the zebra fish body in an in-vivo oxidative stress model, and have the potential of being applied to in-vivo oxidation resistance. The bifidobacterium breve NX-5 disclosed by the invention has a huge potential application prospect in the aspect of oxidation resistance.
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Description

technical field

[0001] The invention relates to the technical field of microorganisms, and more specifically relates to a strain of Bifidobacterium breve NX-5 and its application in anti-oxidation. Background technique

[0002] Reactive oxygen species (ROS) are by-products of cellular aerobic metabolism, mainly including hydrogen peroxide (O 2 2- ), singlet oxygen ( 1 o 2 ), superoxide radicals (O 2 ·- ), hydroxyl radicals (·OH), etc., play an important role in the cell life cycle. Low concentrations of ROS can be used as key signaling molecules in cells to regulate cell growth, proliferation and differentiation. However, the accumulation of ROS can severely damage cellular biomacromolecules such as proteins, lipids, and DNA, leading to a variety of chronic diseases, including atherosclerosis, arthritis, diabetes, neurodegenerative diseases, aging, inflammatory bowel disease, etc. Among them, ROS-mediated oxidative stress-induced senescence can be said to be the most ...

Claims

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