A kind of substituted phenyl indoline carbazole derivative and its preparation method and application

A technology of substituted phenylindolecarbazole and phenylindolecarbazole, which is applied in the field of substituted phenylindolecarbazole derivatives and their preparation, can solve the problem of insensitivity to chemotherapeutic drugs and resistance to It can reduce the level of ROS, induce apoptosis and autophagy, and achieve the effect of simple synthesis method.
CN105218552BInactive Publication Date: 2018-02-27FIELD OPERATION BLOOD TRANSFUSION INST OF PLA SCI ACAD OF MILITARY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FIELD OPERATION BLOOD TRANSFUSION INST OF PLA SCI ACAD OF MILITARY
Publication Date
2018-02-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a substituted phenyl indoline carbazole derivative and a preparation method and application thereof. Please see the structural formula in formula I, wherein Ar adopts hydroxyphenyl or 3-carboxyl-4-hydroxyphenyl or 3,5-dimethoxy-4-hydroxyphenyl. The substituted phenyl indoline carbazole derivative can obviously lower the ROS level in a leukemia cell and can serve as a candidate compound of an antineoplastic drug and / or an anti-leukemia chemotherapeutic agent and / or a leukemia differentiation inducer.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a substituted phenylindolecarbazole derivative and a preparation method and application thereof. Background technique

[0002] According to the statistics of the World Health Organization in 2002, there are about 300,000 new cases of leukemia every year in the world, and the death toll is about 220,000, ranking ninth among fatal malignant tumors. Leukemia is one of the top ten high-incidence malignant tumors in my country, accounting for the sixth place in the incidence of tumors. The incidence of leukemia in my country is about 3 / 100,000-4 / 100,000 population. With the continuous development of leukemia treatment, autologous bone marrow transplantation, allogeneic bone marrow transplantation, stem cell transplantation and gene therapy have made great progress, but all these treatments require effective chemotherapy as the basis.

[0003] There are more than 30 chemotherapy dru...

Claims

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