Application of neomangiferin in vascular endothelial cell protection

A new mangiferin, vascular endothelium technology, applied in the field of medicine, to achieve the effect of increasing total SOD activity, inhibiting oxidative damage and reducing ROS level
CN107397754AInactive Publication Date: 2017-11-28TONGHUA HUAXIA PHARMA +1
2 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TONGHUA HUAXIA PHARMA
Publication Date
2017-11-28
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses application of neomangiferin in vascular endothelial cell protection. The neomangiferin can reduce the ROS level in vascular endothelial cells and enhance the total SOD activity in the vascular endothelial cells; oxidative damage of the cells is inhibited effectively, and then a new acting pathway and the therapeutic mechanism of the neomangiferin on treatment of cardiovascular diseases and diabetic vascular complications are clear; and bases are provided for the clinical medicine of the neomangiferin.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to the application of neomangiferin in protecting vascular endothelial cells. Background technique

[0002] Neomangiferin is isolated from the traditional Chinese medicine Zhimu and is the main active ingredient of Zhimu. Neomangiferin (NMF) is a kind of Xanthone glycosides with molecular formula C 25 h 28 o 16 , the relative molecular mass is 584, and the chemical structural formula is shown in formula (1):

[0003]

[0004] At present, there are many researches on the water extract of Anemarrhena, such as: Ichiki and Miura et al. (Ichiki, H.; Miura, T.; Kubo, M.; Ishihara, E.; Komatsu, Y.; Tanigawa, K.; Okada, M., New antidiabetic compounds, mangiferin and its glucoside. Biological & Pharmaceutical Bulletin 1998, 21, 1389-1390; Miura, T.; Ichiki, H.; Hashimoto, I.; Kubo, M.; Ishihara, E.; Komatsu, Y.; Okada, M.; Ishida, T., Antidiabetic activity of a xanthone compound, ma...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More