A kind of traditional Chinese medicine composition for treating dementia and its preparation method and application

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and preparation thereof, can solve problems such as vascular dementia that have not been treated

Active Publication Date: 2018-08-24
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although studies have shown that a single medicinal material has the effect of treating dementia, there is no report on the combination of two or three combinations of Xia Wu, turmeric and clove for the treatment of vascular dementia

Method used

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  • A kind of traditional Chinese medicine composition for treating dementia and its preparation method and application
  • A kind of traditional Chinese medicine composition for treating dementia and its preparation method and application
  • A kind of traditional Chinese medicine composition for treating dementia and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0181] Take the clove medicinal material, crush it into a coarse powder, and use supercritical CO 2 Extract the volatile oil to obtain extract A; take the summer non-medicinal material, add water to decoct 3 times, reflux for 1 hour each time with 5 times the amount, filter, combine the filtrate, and concentrate under reduced pressure to 1:1 (volume of medicinal solution V / weight of crude drug W ), use 1% HCl to adjust the pH to 3.5, then put on the cation exchange resin column, wash with water and 50% ethanol successively to remove impurities, then elute with 75% alkaline ethanol solution containing 5% ammonia water, collect the eluent, Concentrate under reduced pressure and dry to obtain extract B; take turmeric medicinal material, grind it into coarse powder, and use supercritical CO 2 Extract to obtain extract C. Mix the above three kinds of extracts according to the following weight ratio: A27:B 50:C20 to obtain the extract of the prescription, add conventional pharmaceu...

Embodiment 2

[0183] Take clove medicinal material, crush it into coarse powder, reflux extract with 25 times the amount of 70% ethanol for 1 hour, ultrafilter the extract to obtain ultrafiltrate A; take summer no medicinal material, add 25 times the amount of 40% ethanol, reflux for 1.5 hours, filter , the filtrate is concentrated under reduced pressure to 1:1 (medicine solution volume V / crude drug weight W), and the concentrated solution is directly applied to a macroporous adsorption resin column, followed by elution with 3% NaOH and 10% ethanol to remove impurities, and then 40% ethanol Elution, collecting eluate, ultrafiltration to obtain ultrafiltrate B; take turmeric medicinal material, grind it into coarse powder, reflux extract with 25 times the amount of 95% ethanol for 2 hours, ultrafiltrate the extract to obtain ultrafiltrate C. The above three ultrafiltrates were mixed according to the following weight ratio: A36:B 50:C20 to obtain a mixed solution, which was added with conventi...

Embodiment 3

[0185]Take the clove medicinal material, crush it into a coarse powder, and use the steam distillation method to volatile oil to obtain extract A; take the summer non-medicinal material, add 75% ethanol and extract 12 times the amount twice, the first time for 1.5 hours, the second time for 1 hour, filter After passing through, combine the filtrates, concentrate, concentrate or use 1% HCl to adjust the pH to 4, put on the cation exchange resin, wash with water and 30% ethanol in order to remove impurities, and then elute with 75% alkaline ethanol containing 5% ammonia water , collect the eluent, concentrate under reduced pressure, and dry to obtain extract B; take the turmeric medicinal material, grind it into a coarse powder, extract 2 times with 70% of 12 times the amount, the first time for 2 hours, the second time for 1 hour, and filter , combined the filtrates, concentrated under reduced pressure, and dried to obtain extract C. The above three kinds of extracts are mixed ...

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PUM

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Abstract

The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition as well as a preparation method and an application thereof. The traditional Chinese medicine composition is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight: 1-40 parts of corydalis amabilis extract, 5-80 parts of turmeric extract and 0-50 parts of clove extract. According to the traditional Chinese medicine composition, extract of active parts of corydalis amabilis, turmeric and clove is obtained by using a modern traditional Chinese medicine extraction technique, and various preparations can be prepared. The traditional Chinese medicine composition provided by the invention is capable of reducing brain tissue damage caused by cerebral ischemia, and effectively preventing and treating senile dementia, vascular dementia and vascular sequelae.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition and a preparation method and application thereof. The composition can reduce brain tissue damage caused by cerebral ischemia, and effectively prevent and treat vascular dementia. Background technique [0002] Dementia is a syndrome caused by brain lesions. There are two common types: Alzheimer's disease (also known as senile dementia or Alzheimer's disease) and vascular dementia. [0003] Senile dementia is a primary degenerative disease of the brain, with slow onset and progressive course, and its etiology is still unknown. Patients manifest general dementia, that is, memory, intelligence (including understanding, reasoning, abstract generalization and calculation, etc.), language, operation, etc. decline, personality changes, and some even have mental symptoms. Vascular dementia is the result of cereb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/00A61K36/9066A61P9/10A61P25/28
Inventor 萧伟王振中李永辉李娜丁岗章晨峰
Owner JIANGSU KANION PHARMA CO LTD
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